IHydroxypropyl methylcellulose (HPMC), ekwabizwa ngokuba yi-hypromellose, yipolymer eguquguqukayo esetyenziswa kakhulu kwishishini lamayeza. Yi-semi-synthetic, inert, i-viscoelastic polymer ephuma kwi-cellulose, i-polysaccharide yendalo. I-HPMC ixabiswa ngenxa yokunyibilika kwayo emanzini, indalo engeyiyo eyityhefu, kunye nokukwazi kwayo ukwenza iifilimu kunye neejeli.
1. Isibophelelo kwiiFomu zeThebhulethi
Olunye lolona setyenziso luphambili lwe-HPMC kunyango lufana nesibophelelo kwimixube yeepilisi. I-HPMC iqeshelwe ukuqinisekisa ukuba izithako kwithebhulethi zihambelana kunye kwaye zihlala zizinzile de zityiwe. Iipropati zayo ezibophezelayo ziphucula amandla omatshini weepilisi, okwenza ukuba bangabikho lula ukukrazula okanye ukuphuka ngexesha lokupakisha, ukuthutha kunye nokuphatha. Ukongezelela, i-HPMC i-non-ionic nature iqinisekisa ukuba ayisebenzi kunye nezinye izithako, igcina ukuzinza kunye nokusebenza kwezithako ezisebenzayo zamachiza (APIs).
2. Ukukhutshwa okuLawulwayo kweMatrix
I-HPMC ibalulekile ekuphuhliseni ukukhululwa okulawulwayo (CR) kunye nokukhululwa okuzinzileyo (SR). Olu qulunqo lwenzelwe ukukhulula ichiza ngesantya esimiselweyo, ukugcina amanqanaba echiza angaguquguqukiyo egazini kwixesha elide. Isakhono sokwenza ijeli ye-HPMC xa sidibana nolwelo lwesisu senza ukuba ilungele le njongo. Yenza umaleko wejeli we-viscous ojikeleze ithebhulethi, elawula ukusasazwa kwechiza. Olu phawu lunenzuzo ngokukhethekileyo kumachiza anesalathiso esincinci sonyango, njengoko sinceda ekugcineni i-plasma efunwayo, ngaloo ndlela iphucula ukusebenza kunye nokunciphisa imiphumo emibi.
3. Ukugquma ifilimu
Olunye usetyenziso olubalulekileyo lwe-HPMC kukugquma ifilimu yeetafile kunye neecapsules. Iingubo ezisekelwe kwi-HPMC zikhusela ithebhulethi kwizinto zokusingqongileyo ezifana nokufuma, ukukhanya, kunye nomoya, ezinokuthoba izithako ezisebenzayo. Ifilimu yokugquma iphinde ikhulise isibheno sobuhle bethebhulethi, iphucula i-taste masking, kwaye ingasetyenziselwa ukubonelela ngokhuseleko lwe-enteric, ukuqinisekisa ukuba ichiza likhutshwa kwiindawo ezithile zendlela yesisu. Ngaphezu koko, iingubo ze-HPMC zinokuthi ziyilwe ukuguqula iprofayili yokukhupha iyeza, inceda kwiinkqubo ezijoliswe kuzo.
4. Iarhente yokutyebisa
I-HPMC isebenza njenge-arhente esebenzayo yokutyebisa kulwelo olufana neesyrups kunye nokunqunyanyiswa. Ikhono layo lokunyusa i-viscosity ngaphandle kokuguqula ngokuphawulekayo ezinye iipropati zokuqulunqa kunenzuzo ekuqinisekiseni ukuhanjiswa okufanayo kweyeza ngaphakathi kolwelo, ukuthintela ukuchithwa kweengqungquthela ezimisiweyo, kunye nokubonelela ngomlomo ofunekayo. Le propati ibaluleke kakhulu kwimixube yabantwana kunye ne-geriatric, apho ukulawulwa lula kubaluleke kakhulu.
5. Ukuzinzisa kwiiFowulation zeMixholo
Kwimixube emixholweni efana neekhrimu, iijeli, kunye namafutha aqholiweyo, i-HPMC isebenza njengesizinzisi kunye ne-emulsifier. Inceda ukugcina ukuhambelana kunye nokuzinza kokuqulunqwa, ukuqinisekisa ukuba izithako ezisebenzayo zihanjiswa ngokulinganayo. I-HPMC ikwabonelela ngobume obugudileyo, iphucula ukusetyenziswa kunye nokufunxa kwemveliso eluswini. Ubume bayo obungacaphukiyo buyenza ilungele ukusetyenziswa kwimiqulu yesikhumba esibucayi.
6. Amalungiselelo e-Ophthalmic
I-HPMC isetyenziswa kakhulu kumalungiselelo e-ophthalmic, njengenyembezi ezenziweyo kunye nezisombululo zelensi zoqhagamshelwano. Iimpawu zayo ze-viscoelastic zilinganisa ifilimu yendalo yeenyembezi, inika i-lubrication kunye nomswakama emehlweni. I-HPMC-based eye drops iluncedo kakhulu kubantu abane-syndrome yamehlo eyomileyo, enika isiqabu ekucaphukeni kunye nokungonwabi. Ukongeza, i-HPMC isetyenziswa kwiinkqubo zokuhanjiswa kweziyobisi ze-ocular, apho inceda ekwandiseni ixesha lokunxibelelana lechiza kunye nomphezulu we-ocular, ephucula ukusebenza konyango.
7. Ukuqulunqwa kweCapsule
I-HPMC ikwasetyenziswa ekwenzeni ii-capsules ezinzima nezithambileyo. Isebenza njengenye i-gelatin, inika inketho yemifuno kwiigobolondo ze-capsule. Ii-capsules ze-HPMC zikhethwa ngenxa yesiqulatho sazo sokufuma esisezantsi, esiluncedo kumachiza athintela ukufuma. Banikezela nokuzinza okungcono kwiimeko ezahlukeneyo zokusingqongileyo kwaye akunakwenzeka ukuba bawele ikhonkco, umcimbi oqhelekileyo kunye neepilisi ze-gelatin ezinokuchaphazela iiprofayili zokukhululwa kweziyobisi.
8. Ukwandiswa kweBioavailability
Kwamanye amayeza, i-HPMC inokuphucula ukufumaneka kwe-bioavailability yamachiza anganyibiliki kakuhle. Ngokwenza i-matrix yejeli, i-HPMC inokunyusa izinga lokuchithwa kweyeza kwi-gastrointestinal tract, iququzelele ukufunxa okungcono. Oku kubaluleke kakhulu kumachiza anonyibiliko oluphantsi lwamanzi, njengoko ukunyibilika okuphuculweyo kunokuchaphazela kakhulu ukusebenza kwechiza kunyango.
9. Izicelo ze-Mucoadhesive
I-HPMC ibonisa iipropati ze-mucoadhesive, iyenza ilungele iinkqubo zokuhanjiswa kweziyobisi buccal kunye neelwimi ezingaphantsi. Ezi nkqubo zifuna ukuba ichiza libambelele kwi-mucous membranes, libonelela ngokukhululwa kwexesha elide kunye nokufunxa ngokuthe ngqo kwigazi, lidlula i-metabolism yokuqala. Le ndlela inenzuzo kumachiza athotywayo kwindawo ene-asidi yesisu okanye i-bioavailability yomlomo engafanelekanga.
I-versatility ye-hydroxypropyl methylcellulose (HPMC) ekuqulunqweni kwamachiza ayinakugqithiswa. Usetyenziso lwayo lususela kwi-tablet ebophelelayo kunye nokwalekwa kwefilimu ukuya kwi-thickening kunye ne-stabilizing agents kwimixube eyahlukeneyo. Isakhono se-HPMC sokuguqula iiprofayili zokukhutshwa kwechiza, ukomeleza ukufumaneka kwe-bioavailability, kunye nokubonelela nge-mucoadhesion igxininisa ngakumbi ukubaluleka kwayo kuphuhliso lweenkqubo eziphambili zokuhanjiswa kwechiza. Njengoko ishishini lamayeza liqhubeka nokuvela, indima ye-HPMC iya kwanda, iqhutywa luphando oluqhubekayo kunye neenzame zophuhliso ezijolise ekwandiseni ukuhanjiswa kwamachiza kunye neziphumo zesigulana.
Ixesha lokuposa: Jun-05-2024