Ukusetyenziswa kwe-CMC kuShishino loShishino

ICarboxymethyl cellulose (CMC) ifumana izicelo ezininzi kwishishini lamayeza ngenxa yeempawu zayo eziguquguqukayo. Nalu usetyenziso oluqhelekileyo lwe-CMC kumayeza:

1. Isibophelelo seThebhulethi: I-CMC isetyenziswa ngokubanzi njengesibophelelo kwiinkqubo zethebhulethi ukunika amandla adibeneyo kunye nokuqinisekisa imfezeko yethebhulethi. Inceda ukubamba izithako ezisebenzayo zamachiza (APIs) kunye nabancedisi kunye ngexesha loxinzelelo, ukuthintela ukuphuka kwethebhulethi okanye ukuchithwa. I-CMC ikwakhuthaza ukukhutshwa kweziyobisi ezifanayo kunye nokupheliswa.
2. I-Disintegrant: Ukongeza kwiipropati zayo ezibophelelayo, i-CMC inokusebenza njenge-disintegrant kwi-tablet formulations. Iququzelela ukuqhekeka okukhawulezayo kweepilisi zibe ngamasuntswana amancinci xa evezwe kukufuma, amathe, okanye ulwelo lwesisu, okuvumela ukukhutshwa kweziyobisi ngokukhawuleza kunye nokufanelekileyo kunye nokufunxa emzimbeni.
3. I-Agent ye-Film Coating Agent: I-CMC isetyenziswa njenge-arhente yokugquma ifilimu ukubonelela ngokugudileyo, ukugquma okufanayo kwiipilisi kunye nee-capsules. Ukugquma kunceda ukukhusela iyeza kumswakama, ukukhanya, kunye nomoya, ukufihla incasa engathandekiyo okanye ivumba, kwaye iphucula ukugwinya. Iingubo ezisekelwe kwi-CMC zinokulawula iiprofayili zokukhupha ichiza, ziphucule uzinzo, kwaye ziququzelele ukuchongwa (umzekelo, ngemibala).
4. I-Viscosity Modifier: I-CMC iqashwe njenge-viscosity modifier kulwelo olufana nokuxhonywa, ii-emulsions, iisyrups, kunye namathontsi eliso. Yandisa i-viscosity yokuqulunqwa, ukuphucula ukuzinza kwayo, ukukhululeka kokuphatha, kunye nokubambelela kwiindawo ze-mucosal. I-CMC inceda ukunqumamisa amasuntswana anganyibilikiyo, ukuthintela ukuzinza, nokuphucula ukufana kwemveliso.
5. Izisombululo ze-Ophthalmic: I-CMC isetyenziswa ngokuqhelekileyo kwi-ophthalmic formulations, kubandakanywa amathontsi eliso kunye neegels zokuthambisa, ngenxa ye-mucoadhesive yayo egqwesileyo kunye neempawu zokuthambisa. Inceda ukuthambisa kunye nokukhusela umphezulu we-ocular, ukuphucula ukuzinza kwefilimu yeenyembezi, kunye nokunciphisa iimpawu zeso esomileyo. Amathontsi eliso esekwe kwi-CMC anokwandiswa ixesha lokuqhagamshelwa kwechiza kwaye aphucule ukufumaneka kwe-ocular bioavailability.
6. Amalungiselelo asemxholweni: I-CMC ibandakanywe kwimixube eyahlukahlukeneyo emixholweni efana neekhrimu, izinto zokuthambisa, iijeli, kunye nezithambiso njenge-arhente etyebisayo, i-emulsifier, isizinzi, okanye isiphuculi se-viscosity. Iphucula ukusasazeka kwemveliso, i-skin hydration, kunye nokuzinza kokwakheka. Amalungiselelo asekwe kwi-CMC asetyenziselwa ukukhuselwa kwesikhumba, ukugalela amanzi, kunye nonyango lweemeko zedermatological.
7. Ukunxitywa kwamanxeba: I-CMC isetyenziswa kwiimveliso zokhathalelo lwenxeba ezifana nokunxitywa kwe-hydrogel kunye neejeli zamanxeba zokugcina ukufuma kunye neempawu zokukhuthaza ukuphilisa. Inceda ukudala indawo yenxeba efumileyo evumela ukuvuselelwa kwezicubu, ikhuthaza ukuchithwa kwe-autolytic, kwaye ikhawulezise ukuphiliswa kwenxeba. Izinxibo ezisekwe kwi-CMC zibonelela ngomqobo okhuselayo, zifunxa i-exudate, kwaye zinciphise iintlungu.
8. I-excipient in Formulations: I-CMC isebenza njenge-excipient eguquguqukayo kwiindlela ezahlukeneyo zokuxuba amayeza, kubandakanywa iifom zedosi yomlomo eqinile (iipilisi, ii-capsules), iifom zedosi yolwelo (ukumiswa, izisombululo), iifom zedosi ye-semisolid (i-ointments, i-creams), kunye neemveliso ezizodwa (izitofu, izitofu, iinkqubo zokuhanjiswa kofuzo). Iphucula ukusebenza kokuqulunqwa, ukuzinza, kunye nokwamkeleka kwesigulane.

I-CMC idlala indima ebalulekileyo kushishino loxubo-mayeza ngokuphucula umgangatho, ukusebenza kakuhle, kunye namava esigulane kuluhlu olubanzi lweemveliso zamachiza kunye nokuqulunqwa. Ukhuseleko lwayo, i-biocompatibility, kunye nokwamkelwa okusemthethweni kwenza ukuba kube lukhetho olukhethwayo kubavelisi bamayeza kwihlabathi liphela.