Ukusetyenziswa kwe-HPMC kuShishino loShishino

IHydroxypropyl methylcellulose (HPMC), ekwabizwa ngokuba yi-hypromellose, isetyenziswa kakhulu kwishishini loxubo mayeza ngenxa yeempawu zayo eziguquguqukayo. Nazi ezinye izicelo eziqhelekileyo ze-HPMC kumayeza:

1. I-Tablet Binder: I-HPMC iqhele ukusetyenziswa njengesibophelelo kwimixube yethebhulethi ukunika ubumbano kunye nokuphucula ubulukhuni bethebhulethi. Inceda ukubamba izithako zomgubo kunye ngexesha loxinzelelo, okukhokelela kwiipilisi ezinobumba kunye namandla omatshini.
2. I-Agent ye-Film Coating Agent: I-HPMC isetyenziswa njenge-agent e-coating yefilimu ukubonelela ngokhuseleko kunye / okanye ukugquma kobuhle kwiipilisi kunye neepilisi. Ifilimu yokugquma iphucula imbonakalo, i-taste masking, kunye nokuzinza kwefomu yedosi yamayeza. Ukongeza, inokulawula i-kinetics yokukhululwa kwechiza, ikhusele iyeza kubumanzi, kwaye iququzelele ukugwinya.
3. I-Matrix Yangaphambili: I-HPMC isetyenziswa njenge-matrix yangaphambili ekukhutshweni okulawulwayo kunye nokukhutshwa okuzinzileyo kwe-tablet formulations. Yenza umaleko wejeli phezu kwe-hydration, elawula ukusasazwa kwechiza ukusuka kwifomu yedosi, ekhokelela ekukhululweni kwechiza ixesha elide kunye nesiphumo sonyango esizinzileyo.
4. I-Disintegrant: Kwezinye iifomyula, i-HPMC inokusebenza njenge-disintegrant, ikhuthaza ukuhlukana ngokukhawuleza kunye nokusasazwa kweepilisi okanye ii-capsules kumzila wesisu. Oku kuququzelela ukunyibilika kwechiza kunye nokufunxa, kuqinisekisa ukufumaneka kwe-bioavailability okugqibeleleyo.
5. I-Viscosity Modifier: I-HPMC isetyenziswa njenge-viscosity modifier kulwelo kunye ne-semi-solid formulations ezifana nokuxhonywa, i-emulsions, i-gel, kunye ne-ointments. Ibonelela ngolawulo lwe-rheological, iphucula ukuzinza kokunqunyanyiswa, kwaye iphucula ukusasazeka kunye nokubambelela kwimiqulu yezihloko.
6. I-Stabilizer kunye ne-Emulsifier: I-HPMC isetyenziswe njenge-stabilizer kunye ne-emulsifier kwi-formulation ye-liquid ukukhusela ukuhlukana kwesigaba, ukuphucula ukuzinza kokumiswa, kunye nokuphucula i-homogeneity yemveliso. Ngokuqhelekileyo isetyenziselwa ukumiswa komlomo, iisyrups, kunye ne-emulsions.
7. I-Agent etyebisayo: I-HPMC isetyenziswa njenge-agent yokuqina kwiindlela ezahlukeneyo zamachiza ukwandisa i-viscosity kunye nokubonelela ngeempawu ezifunwayo ze-rheological. Iphucula ukuthungwa kunye nokuhambelana kwamalungiselelo eengqungquthela ezifana ne-creams, i-lotions, kunye neegels, ukuphucula ukusasazeka kunye nokuziva kwesikhumba.
8. I-Opacifier: I-HPMC ingasetyenziswa njenge-ejenti yokucoca kwimixube ethile ukunika ulawulo lokungafihli okanye ukungafihli. Le propati iluncedo ngokukhethekileyo kwi-ophthalmic formulations, apho i-opacity inokuphucula ukubonakala kwemveliso ngexesha lokulawula.
9. Isithuthi kwiiNkqubo zokuhanjiswa kweziyobisi: I-HPMC isetyenziswa njengesithuthi okanye umthwali kwiinkqubo zokuhanjiswa kweziyobisi ezifana ne-microspheres, nanoparticles, kunye ne-hydrogels. Inokuthi ifake iziyobisi, ilawule i-kinetics yokukhululwa kwechiza, kwaye ikhulise uzinzo kumachiza, ibonelela ngokunikezelwa kwechiza ekujoliswe kulo kunye nokulawulwayo.

I-HPMC yi-excipient ye-pharmaceutical excipient enoluhlu olubanzi lwezicelo, kubandakanywa ukubopha i-tablet, i-coating yefilimu, ukubunjwa kwe-matrix ekhutshwe ngokulawulwayo, ukuchithwa, ukuguqulwa kwe-viscosity, ukuzinzisa, i-emulsification, i-thickening, i-opacification, kunye nokuqulunqwa kwenkqubo yokuhanjiswa kweziyobisi. Ukusetyenziswa kwayo kunegalelo ekuphuhliseni iimveliso zamayeza ezikhuselekileyo, ezisebenzayo, nezilungele isigulane.