IHydroxypropyl methylcellulose (HPMC) yipolymer yokwenziwa kwesemi-synthetic esetyenziswa kakhulu kumashishini amaninzi, ngakumbi kwicandelo lamayeza. HPMC iye yaba excipient eyimfuneko kumalungiselelo amayeza ngenxa biocompatibility yayo, non-ityhefu kunye neempawu ezibalaseleyo emzimbeni kunye nemichiza.
(1) Iimpawu ezisisiseko zebakala lamayeza i-HPMC
I-HPMC yi-ether ye-cellulose engekho i-ionic elungiselelwe ukusabela kweselulosi kunye nepropylene oxide kunye ne-methyl chloride phantsi kweemeko ze-alkaline. Ulwakhiwo lwalo lweekhemikhali ezizodwa lunika i-HPMC ukunyibilika okugqwesileyo, ukutyeba, ukwenza ifilimu kunye neempawu ze-emulsifying. Ezi zilandelayo zezinye iimpawu eziphambili ze-HPMC:
Ukunyibilika kwamanzi kunye nokuxhomekeka kwe-pH: I-HPMC inyibilika emanzini abandayo kwaye yenza isisombululo se-viscous esicacileyo. I-viscosity yesisombululo sayo ihambelana nokugxininiswa kunye nobunzima be-molecular, kwaye inozinzo oluqinileyo kwi-pH kwaye inokuhlala izinzile kwiindawo zombini kunye ne-alkaline.
Iimpawu ze-Thermogel: I-HPMC ibonisa iimpawu ezizodwa ze-thermogel xa ishushu. Inokwenza ijeli xa ishushu kwiqondo lobushushu elithile kwaye ibuyele kwimeko yolwelo emva kokupholisa. Le propati ibaluleke kakhulu kumalungiselelo okukhululwa kwechiza okokoko.
I-Biocompatibility kunye ne-non-toxicity: Ekubeni i-HPMC iphuma kwi-cellulose kwaye ayinamrhumo kwaye ayiyi kusabela kunye nezinye izithako, ine-biocompatibility egqwesileyo kwaye ayiyi kufakwa emzimbeni. Yinto encedisayo engeyotyhefu.
(2) Ukusetyenziswa kweHPMC kumayeza
I-HPMC isetyenziswa kakhulu kwishishini loxubo-mayeza, ibandakanya iindawo ezininzi ezifana namayeza omlomo, asematheni kunye natofwayo. Imikhomba-ndlela ephambili yesicelo yile ilandelayo:
1. Izinto zokwenza ifilimu kwiipilisi
I-HPMC isetyenziswa ngokubanzi kwinkqubo yokugquma iipilisi njengento yokwenza ifilimu. Itheyibhile yokwaleka ayikwazi ukukhusela kuphela iziyobisi kwimpembelelo yendawo yangaphandle, njengokufuma kunye nokukhanya, kodwa kwakhona ukugubungela iphunga elibi kunye nencasa yeziyobisi, ngaloo ndlela kuphuculwe ukuthotyelwa kwesigulane. Ifilimu eyenziwe yi-HPMC inokuxhathisa okuhle kwamanzi kunye namandla, anokwandisa ngokufanelekileyo ixesha leshelufu lamachiza.
Kwangaxeshanye, i-HPMC ingasetyenziswa njengeyona nxalenye iphambili yeembrane ezilawulwayo zokukhutshwa kwemveliso yokukhutshwa okuzinzileyo kunye neepilisi ezilawulwayo. Iimpawu zayo ze-thermal zejeli zivumela ukuba amachiza akhululwe emzimbeni kwinqanaba lokukhululwa kwangaphambili, ngaloo ndlela kufezekiswa umphumo wonyango olude olusebenzayo. Oku kubaluleke kakhulu kunyango lwezifo ezingapheliyo, ezifana neemfuno zamayeza exesha elide kwizigulane ezinesifo sikashukela kunye noxinzelelo lwegazi.
2. Njenge-arhente yokukhutshwa okuzinzileyo
I-HPMC isetyenziswa ngokubanzi njenge-arhente yokukhululwa ezinzileyo kumalungiselelo amachiza omlomo. Ngenxa yokuba inokwenza ijeli emanzini kwaye umaleko wejeli uyancibilika ngokuthe ngcembe njengoko iyeza likhutshwa, linokulawula ngokufanelekileyo izinga lokukhutshwa kwechiza. Esi sicelo sibaluleke kakhulu kumachiza afuna ukukhutshwa kwexesha elide, njenge-insulin, i-antidepressants, njl.
Kwimeko ye-gastrointestinal, i-gel layer ye-HPMC inokulawula izinga lokukhululwa kweyeza, ukuphepha ukukhululwa ngokukhawuleza kweyeza ngexesha elifutshane, ngaloo ndlela kuncitshiswe iziphumo ebezingalindelekanga kunye nokwandisa ukusebenza kakuhle. Le propati yokukhutshwa ngokuqhubekayo ifaneleka ngokukodwa kunyango lwamachiza afuna ukugxilwa kweyeza elizinzileyo legazi, njenge-antibiotics, i-anti-epileptic drugs, njl.
3. Njengomdibanisi
I-HPMC isoloko isetyenziswa njengesibophelelo kwinkqubo yokuvelisa ithebhulethi. Ngokongeza i-HPMC kwiincinci zeziyobisi okanye i-powders, i-fluidity yayo kunye nokunamathela kunokuphuculwa, ngaloo ndlela kuphuculwe umphumo woxinzelelo kunye namandla ethebhulethi. I-non-toxicity kunye nokuzinza kwe-HPMC kuyenza ibe yi-binder efanelekileyo kwiipilisi, iigranules kunye ne-capsules.
4. Njenge-thickener kunye ne-stabilizer
Kumalungiselelo olwelo, i-HPMC isetyenziswa ngokubanzi njenge-thickener kunye ne-stabilizer kulwelo olwahlukeneyo lomlomo, amathontsi eliso kunye ne-topical creams. Ipropathi yayo etyebileyo inokunyusa i-viscosity yamachiza angamalwelo, iphephe ukuhluzwa kweziyobisi okanye imvula, kwaye iqinisekise ukuhanjiswa okufanayo kwezithako zeziyobisi. Kwangaxeshanye, ukuthambisa kunye neepropathi zokuthambisa ze-HPMC ziyenza ikwazi ukunciphisa ngokufanelekileyo ukungonwabi kwamehlo kumathontsi eliso kwaye ikhusele amehlo ekucaphukeni kwangaphandle.
5. Isetyenziswe kwii-capsules
Njenge-cellulose ephuma kwisityalo, i-HPMC ine-biocompatibility efanelekileyo, iyenza ibe yinto ebalulekileyo yokwenza iipilisi zezityalo. Xa kuthelekiswa neepilisi zegelatin yezilwanyana zemveli, iipilisi ze-HPMC zinozinzo olungcono, ngakumbi kubushushu obuphezulu kunye neendawo zokufuma eziphezulu, kwaye akukho lula ukukhubaza okanye ukunyibilika. Ukongeza, ii-capsules ze-HPMC zilungele abantu abatya imifuno kunye nezigulane ezingadibaniyo ne-gelatin, ukwandisa ububanzi bokusetyenziswa kweziyobisi ze-capsule.
(3) Ezinye izicelo zeziyobisi zeHPMC
Ukongeza kwezi zicelo ziqhelekileyo zamachiza, i-HPMC isenokusetyenziswa kwiindawo ezithile zamachiza. Ngokomzekelo, emva kotyando lwamehlo, i-HPMC isetyenziselwa amaconsi esweni njenge-lubricant yokunciphisa ukungqubuzana kwi-eyeball kunye nokukhuthaza ukubuyiswa. Ukongeza, i-HPMC ingasetyenziswa kwi-ointments kunye neegels ukukhuthaza ukufunxwa kweziyobisi kunye nokuphucula ukusebenza kwamachiza asekuhlaleni.
ibakala Pharmaceutical HPMC idlala indima ebalulekileyo kumalungiselelo amachiza ngenxa iimpawu zayo ezibalaseleyo emzimbeni kunye nemichiza. Njengoko excipient amayeza multifunctional, HPMC ayikwazi nje ukuphucula uzinzo amachiza kunye nokulawula ukukhutshwa kwamachiza, kodwa nokuphucula amava ukuthatha ichiza kunye nokwandisa ukuthotyelwa isigulane. Ngokuqhubela phambili okuqhubekayo kobuchwepheshe boxubo-mayeza, indawo yokusetyenziswa kwe-HPMC iya kuba banzi kwaye idlale indima ebaluleke kakhulu kuphuhliso lwamachiza kwixesha elizayo.
Ixesha lokuposa: Sep-19-2024