Ukumiselwa koBunyulu be-HPMC Hydroxypropyl Methyl Cellulose

IHydroxypropyl methylcellulose, eyaziwa ngokuba yi-HPMC, sisixhobo esisetyenziswa kakhulu kumayeza kunye nesongezo sokutya. Ngenxa yokunyibilika kwayo okugqwesileyo, ukukwazi ukubophelela kunye neepropati zokwenza ifilimu, isetyenziswe ngokubanzi kumashishini amayeza. I-HPMC ikwasetyenziswa ngokuqhelekileyo kushishino lokutya njenge-thickener, emulsifier and stabilizer. Ukucoceka kwe-HPMC kubaluleke kakhulu kumashishini amayeza kunye nokutya njengoko kuchaphazela ukusebenza kakuhle kunye nokhuseleko lwemveliso. Eli nqaku liza kuxubusha ukuzimisela HPMC ubunyulu kunye neendlela zayo.

Ziziphi ii-HPMCs?

IHydroxypropylmethylcellulose (HPMC) yi-ether eselulosi ephuma kwi-methylcellulose. Ubunzima bayo bemolekyuli yi-10,000 ukuya kwi-1,000,000 yeeDaltons, kwaye ingumgubo omhlophe okanye omhlophe, ongenavumba kwaye awunayo incasa. I-HPMC inyibilika ngokulula emanzini, kwaye inyibilika kwezinye izinyibilikisi eziphilayo ezifana ne-ethanol, ibutanol, kunye neklorofomu. Ineempawu ezizodwa ezifana nokugcinwa kwamanzi, ukutyeba kunye nokukwazi ukubopha, okwenza kube yinto efanelekileyo kumashishini amayeza kunye nokutya.

Ukumiselwa kobunyulu be-HPMC

Ukucoceka kweHPMC kuxhomekeke kwizinto ezininzi ezifana neqondo lokuthatha indawo (DS), isiqulatho sokufuma kunye nesiqulatho sothuthu. I-DS imele inani lamaqela e-hydroxyl endaweni yamaqela e-hydroxypropyl kwi-molecule ye-cellulose. Iqondo eliphezulu lokutshintsha linyusa ukunyibilika kwe-HPMC kwaye liphucula isakhono sokwenza ifilim. Ngokuchaseneyo, iqondo eliphantsi lokutshintsha lingabangela ukunyibilika okuncitshisiweyo kunye neempawu ezimbi zokwenza ifilimu.

Indlela ye-HPMC yokuQinisekisa ubunyulu

Kukho iindlela ezininzi zokumisela ubunyulu be-HPMC, kubandakanywa i-acid-base titration, uhlalutyo lwe-elemental, i-high-performance liquid chromatography (HPLC), kunye ne-infrared spectroscopy (IR). Nazi iinkcukacha zendlela nganye:

acid-base titration

Indlela isekelwe kwi-neutralization reaction phakathi kwe-acidic kunye namaqela asisiseko kwi-HPMC. Okokuqala, i-HPMC ichithwa kwi-solvent kunye nomthamo owaziwayo we-asidi okanye isisombululo sesiseko soxinaniso esaziwayo songezwa. I-Titration yenziwa de i-pH ifikelele kwindawo engathathi hlangothi. Ukususela kwisixa se-asidi okanye isiseko esisetyenzisiweyo, iqondo lokutshintshwa lingabalwa.

Uhlalutyo olusisiseko

Uhlalutyo lwe-Elemental lulinganisa ipesenti yento nganye ekhoyo kwisampulu, kuquka i-carbon, i-hydrogen, kunye ne-oxygen. Iqondo lokutshintsha lingabalwa ukusuka kwisixa sento nganye ekhoyo kwisampulu yeHPMC.

I-High Performance Liquid Chromatography (HPLC)

I-HPLC bubuchule bokuhlalutya obusetyenziswa ngokubanzi obahlula amacandelo omxube ngokusekelwe ekusebenzisaneni kwawo nezigaba ezimileyo nezihambayo. Kwi-HPMC, iqondo lokutshintsha lingabalwa ngokulinganisa umlinganiselo we-hydroxypropyl kumaqela e-methyl kwisampulu.

I-Infrared Spectroscopy (IR)

I-infrared spectroscopy bubuchule bohlalutyo obulinganisa ukufunxwa okanye ukuhanjiswa kwemitha ye-infrared ngesampulu. I-HPMC ineencopho zokufunxa ezahlukeneyo ze-hydroxyl, i-methyl kunye ne-hydroxypropyl, enokusetyenziswa ukumisela iqondo lokuthatha indawo.

Ukucoceka kwe-HPMC kubaluleke kakhulu kumashishini amayeza kunye nokutya, kwaye ukuzimisela kwayo kubalulekile ukuqinisekisa ukhuseleko kunye nokusebenza kakuhle kwemveliso yokugqibela. iindlela ezininzi ziyafumaneka ukumisela ubunyulu HPMC, kuquka acid-base titration, uhlalutyo elemental, HPLC, kunye IR. Indlela nganye ineenzuzo zayo kunye nokungonakali kwaye inokukhethwa ngokweemfuno ezithile zesicelo. Ukugcina ubunyulu be-HPMC, kufuneka igcinwe kwindawo eyomileyo, epholileyo kude nelanga kunye nezinye izinto ezingcolisayo.