I-Hydroxypropyl Methylcellulose (HPMC) isetyenziswa ngokuqhelekileyo kwi-cellulose derivative kunye noluhlu olubanzi lwezicelo, ezifana neyeza, ukutya, izinto zokwakha kunye nezinto zokuthambisa. I-HPMC yi-non-ionic, i-semi-synthetic, i-polymer engasebenziyo kunye nokunyibilika kwamanzi okugqwesileyo, ukuqina, ukunamathela kunye neempawu zokwenza ifilimu.
Ubume kunye neepropati ze-HPMC
I-HPMC yi-cellulose elungisiweyo eveliswa ngokuphendula i-cellulose nge-methyl chloride kunye ne-propylene oxide. Ulwakhiwo lwalo lwemolekyuli luqulethe zombini i-methyl kunye ne-hydroxypropyl substituents, enika i-HPMC iipropati ezikhethekileyo zomzimba kunye neekhemikhali, ezifana nokunyibilika okugqwesileyo, ukukhuselwa kwe-colloid kunye neepropati zokwenza ifilimu. I-HPMC inokohlulwa ibe ziinkcukacha ezininzi ngokuhambelana nezinto ezibambeleyo ezahlukeneyo, kwaye inkcazo nganye ine-solubility eyahlukileyo kunye nokusetyenziswa emanzini.
Ukunyibilika kwe-HPMC emanzini
Indlela yokuphelisa
I-HPMC isebenzisana neemolekyuli zamanzi ngokusebenzisa iibhondi ze-hydrogen ukwenza isisombululo. Inkqubo yokuchithwa kwayo ibandakanya iimolekyuli zamanzi ngokuthe ngcembe zingena phakathi kwamatyathanga e-molecular of HPMC, ukutshabalalisa ukudibanisa kwayo, ukwenzela ukuba amakhonkco e-polymer asasazeke emanzini ukuze enze isisombululo esifanayo. I-solubility ye-HPMC inxulumene ngokusondeleyo nobunzima bayo bemolekyuli, uhlobo olubambeleyo kunye neqondo lokuthatha indawo (DS). Ngokubanzi, iqondo eliphezulu lokutshintshela indawo, kokukhona iphezulu ukunyibilika kwe-HPMC emanzini.
Isiphumo sobushushu ekunyibilikeni
Ubushushu yenye yezinto ezibalulekileyo ezichaphazela ukunyibilika kwe-HPMC. Ukunyibilika kwe-HPMC emanzini kubonisa iimpawu ezahlukeneyo njengoko ubushushu butshintsha:
Ukuchithwa kweqondo lokushisa: I-HPMC inzima ukunyibilika emanzini abandayo (ngokuqhelekileyo ngaphantsi kwe-40 ° C), kodwa inokunyibilika ngokukhawuleza xa ishushu kwi-60 ° C okanye ngaphezulu. Kwi-HPMC ye-viscosity ephantsi, iqondo lobushushu lamanzi elijikeleze i-60 ° C lidla ngokuba lolona bushushu lifanelekileyo lokunyibilika. Kwi-HPMC ye-viscosity ephezulu, olona luhlu lobushushu bokupheliswa lunokuba phezulu ukuya kuma-80°C.
I-Gelation ngexesha lokupholisa: Xa isisombululo se-HPMC sitshisa kwiqondo lokushisa elithile (ngokuqhelekileyo i-60-80 ° C) ngexesha lokuchithwa kwaye emva koko lipholile ngokukhawuleza, i-gel ye-thermal iya kwenziwa. Le gel ye-thermal iyazinza emva kokupholisa kwiqondo lokushisa kwaye inokusasazwa kwakhona emanzini abandayo. Le nto ibaluleke kakhulu ekulungiseleleni izisombululo ze-HPMC ngeenjongo ezithile ezithile (ezifana ne-capsules yokukhululwa okuqhubekayo kweziyobisi).
Ukusebenza kakuhle kokupheliswa: Ngokubanzi, amaqondo obushushu aphezulu anokukhawulezisa inkqubo yokupheliswa kwe-HPMC. Nangona kunjalo, ubushushu obuphezulu kakhulu bunokukhokelela ekuthotyweni kwepolymer okanye ukuncipha kwe-viscosity yokupheliswa. Ngoko ke, ekusebenzeni kwangempela, ukushisa okufanelekileyo kokutshatyalaliswa kufuneka kukhethwe njengoko kufunekayo ukuze kugwenywe ukuthotywa okungadingekile kunye nokutshintsha kwepropati.
Impembelelo ye-pH ekunyibilikeni
Njenge-polymer engeyiyo i-ionic, i-solubility ye-HPMC emanzini ayichaphazeli ngokuthe ngqo ngexabiso le-pH yesisombululo. Nangona kunjalo, iimeko ezigqithisileyo ze-pH (ezifana neendawo eziqinileyo ze-acidic okanye ezine-alkaline) zinokuchaphazela iimpawu zokuchithwa kwe-HPMC:
Iimeko ze-Acidic: Ngaphantsi kweemeko eziqinileyo ze-acidic (pH <3), ezinye iibhondi zekhemikhali ze-HPMC (ezifana neebhondi ze-ether) zingatshatyalaliswa yi-acidic medium, ngaloo ndlela ichaphazele ukunyibilika kwayo kunye ne-dispersibility. Nangona kunjalo, kuluhlu lwe-asidi ebuthathaka ngokubanzi (pH 3-6), i-HPMC isenokuthi inyibilike kakuhle. Iimeko ze-alkaline: Ngaphantsi kweemeko ze-alkaline ezinamandla (pH> 11), i-HPMC inokuthotywa, okuqhelekileyo ngenxa yokusabela kwe-hydrolysis ye-chain ye-hydroxypropyl. Ngaphantsi kweemeko ze-alkaline ezibuthathaka (pH 7-9), i-solubility ye-HPMC ngokuqhelekileyo ayichaphazeleki kakhulu.
Indlela yokuchithwa kwe-HPMC
Ukuze ukunyibilikisa ngempumelelo HPMC, ezi ndlela zilandelayo zidla ngokusetyenziswa:
Indlela yokusasazwa kwamanzi abandayo: Yongeza kancinane umgubo weHPMC emanzini abandayo ngelixa uvuselela ukuwasasaza ngokulinganayo. Le ndlela inokuthintela HPMC ukusuka ngqo agglomerating emanzini, kwaye isisombululo yenza umaleko colloidal zokhuselo. Emva koko, ngokuthe ngcembe uyitshise ukuya kwi-60-80 ° C ukuyinyibilikisa ngokupheleleyo. Le ndlela ilungele ukuchithwa kwe-HPMC eninzi.
Indlela yokusasazwa kwamanzi ashushu: Yongeza i-HPMC emanzini ashushu kwaye uwashukumise ngokukhawuleza ukuwanyibilikisa ngokukhawuleza kubushushu obuphezulu. Le ndlela ifanelekile kwi-HPMC ephezulu-viscosity, kodwa kufuneka kuqwalaselwe ekulawuleni ubushushu ukuphepha ukuthotywa.
Isisombululo sendlela yokulungiselela kwangaphambili: Okokuqala, i-HPMC inyibilika kwi-solvent ye-organic (efana ne-ethanol), emva koko amanzi adityaniswe ngokuthe ngcembe ukuyiguqula ibe yisisombululo esimanzi. Le ndlela ifanelekile kwiimeko ezikhethekileyo zesicelo kunye neemfuno eziphezulu zokunyibilika.
Inkqubo yokuphelisa kwizicelo ezibonakalayo
Kwizicelo ezisebenzayo, inkqubo yokupheliswa kwe-HPMC kufuneka iphuculwe ngokosetyenziso oluthile. Ngokomzekelo, kwintsimi yamachiza, ngokuqhelekileyo kuyimfuneko ukwenza isisombululo se-colloidal esifana kakhulu kwaye sizinzile, kunye nokulawulwa okungqongqo kweqondo lokushisa kunye ne-pH kuyadingeka ukuze kuqinisekiswe i-viscosity kunye nomsebenzi we-biological wesisombululo. Kwizinto zokwakha, i-solubility ye-HPMC ichaphazela iipropati zokwenza ifilimu kunye namandla acinezelayo, ngoko ke eyona ndlela ingcono yokuchithwa kufuneka ikhethwe ngokudibanisa neemeko ezithile zokusingqongileyo.
Ukunyibilika kwe-HPMC emanzini kuchatshazelwa zizinto ezininzi, ngakumbi ubushushu kunye ne-pH. Ngokubanzi, i-HPMC inyibilika ngokukhawuleza kumaqondo obushushu aphezulu (60-80°C), kodwa isenokuthomalalisa okanye inganyibiliki kakhulu phantsi kweemeko ezigqithisileyo ze-pH. Ke ngoko, kwizicelo ezisebenzayo, kuyafuneka ukuba ukhethe ubushushu obufanelekileyo bokupheliswa kunye noluhlu lwe-pH ngokwendlela ethile yokusetyenziswa kunye neemeko zokusingqongileyo zeHPMC ukuqinisekisa ukunyibilika kwayo okuhle kunye nokusebenza kwayo.
Ixesha lokuposa: Jun-25-2024