IHydroxypropyl methylcellulose (HPMC) iye yaba sisithako esisetyenziswa ngokuqhelekileyo kwizicoci zokuhlamba iimpahla ngenxa yokujiya kwayo okugqwesileyo, ugcino lwamanzi kunye neempawu zokufaka imifuziselo. I-HPMC yinto ephuma kwi-synthetic ye-cellulose, ipholima yendalo efumaneka kwizityalo. I-HPMC yipolima enyibilikayo emanzini eneentlobo ngeentlobo zezicelo kushishino nakwimveliso. Kwizinto zokuhlamba iimpahla, i-HPMC isetyenziselwa ukomeleza ukusebenza kokucoca kukonke kwemveliso.
I-HPMC yinto enyibilikayo kakhulu. I-solubility ye-HPMC ixhomekeke kwizinto ezininzi, kuquka ubunzima bayo be-molecular, degree of substitution, kunye nobushushu. Ngokubanzi, i-HPMC ibonisa ukunyibilika okuphezulu kwamanzi kunye nezinyibilikisi zepolar. I-HPMC inoluhlu lwe-molecular weight 10,000 ukuya kwi-1,000,000 Da kwaye ngokuqhelekileyo ine-solubility emanzini ye-1% ukuya kwi-5%, kuxhomekeke kwibakala kunye nokugxininiswa. Ukunyibilika kwe-HPMC emanzini kuchatshazelwa yimiba eyahlukeneyo efana ne-pH, ubushushu kunye noxinzelelo.
Kwizinto zokucoca iimpahla, i-HPMC eneemfuno zokunyibilika okuphezulu kufuneka isetyenziswe ukuqinisekisa ukunyibilika okufanelekileyo kwesicoci emanzini. Ukunyibilika kwe-HPMC kwizicoci zokuhlamba iimpahla kuchatshazelwa zizinto ezininzi, kubandakanywa ubukho bezinye izithako, ubushushu bomjikelo wokuhlamba kunye nobulukhuni bamanzi. Ubulukhuni bamanzi buchaphazela ukunyibilika kwe-HPMC kuba iindawo eziphezulu zeeminerali ezinyityilisiweyo, ezifana ne-calcium kunye ne-magnesium, ziphazamisana nokuchithwa kwe-HPMC emanzini.
Kubalulekile ukukhetha ibakala elifanelekileyo le-HPMC elineemfuno zokunyibilika okuphezulu kunye nokukwazi ukumelana neemeko zokuhlamba ezingqongqo. Amabanga e-HPMC aneemfuno zokunyibilika okuphezulu ayacetyiswa kwizicoci zokuhlamba iimpahla ukuqinisekisa ukuba imveliso inyibilika ngokulula emanzini kwaye ibonelela ngokucocwa kokusebenza okungaguqukiyo. Ukusebenzisa i-HPMC eneemfuno zokunyibilika okuphantsi kunokubangela ukuba isicoci sidibane kwaye singqubeke emanzini, sinciphise ukusebenza kakuhle kwemveliso.
Ukunyibilika kwe-HPMC kubaluleke kakhulu ekusetyenzisweni kwayo kwiintlobo ngeentlobo zezicelo, kubandakanywa nezicoci zokuhlamba impahla. Ukunyibilika kwe-HPMC emanzini kuchatshazelwa zizinto ezininzi, kubandakanya i-pH, ubushushu, kunye noxinzelelo. Kwizinto zokuhlamba iimpahla, i-HPMC eneemfuno zokunyibilika okuphezulu kufuneka isetyenziswe ukuqinisekisa ukuchithwa okufanelekileyo kwemveliso emanzini. Ukusebenzisa i-HPMC eneemfuno zokunyibilika okuphantsi kunokubangela ukuba isicoci sidibane kwaye singqubeke, sinciphise ukusebenza kwemveliso. Ke ngoko, kuyafuneka ukuba ukhethe amabakala afanelekileyo eHPMC aneemfuno zokunyibilika okuphezulu kwizicoci zokuhlambela iimpahla ukuqinisekisa ukusebenza kokucoca okungaguqukiyo.
Ixesha lokuposa: Sep-18-2023