I-HPMC (ihydroxypropyl methylcellulose)iicapsules yenye yezinto eziqhelekileyo ezisetyenziswa kwi-capsule kumayeza anamhlanje kunye nezongezo zokutya. Isetyenziswa kakhulu kwishishini lamachiza kunye nemveliso yemveliso yokhathalelo lwempilo, kwaye ithandwa ngabatya imifuno kunye nezigulane ezine-allergies ngenxa yezithako zayo eziphuma kwisityalo. Ii-capsules ze-HPMC zinyibilika ngokuthe ngcembe kwi-gastrointestinal tract emva kokufunxa, ngaloo ndlela zikhulula izithako ezisebenzayo kuzo.
1. Isishwankathelo sexesha lokuchithwa kwe-capsule ye-HPMC
Ixesha lokuchithwa kwee-capsules ze-HPMC lihlala liphakathi kwe-10 kunye ne-30 imizuzu, eyona nto ixhomekeke kubukhulu bodonga lwe-capsule, inkqubo yokulungiselela, ubunjani bemixholo ye-capsule, kunye nezinto zokusingqongileyo. Xa kuthelekiswa neepilisi zegelatin zemveli, izinga lokuchithwa kwee-capsules ze-HPMC licotha kancinane, kodwa lisengaphakathi koluhlu olwamkelekileyo lwendlela yesisu somntu. Ngokuqhelekileyo, iziyobisi okanye izondlo zinokukhutshwa ngokukhawuleza kwaye zifakwe emva kokuba i-capsule ichithwe, iqinisekisa ukuba i-bioavailability yezithako ezisebenzayo.
2. Izinto ezichaphazela izinga lokuchithwa kwee-capsules ze-HPMC
ixabiso pH kunye nobushushu
Iipilisi ze-HPMC zine-solubility engcono kwiindawo ezine-acidic kunye nokungathathi hlangothi, ngoko zinokunyibilika ngokukhawuleza esiswini. Ixabiso le-pH lesisu lihlala liphakathi kwe-1.5 kunye ne-3.5, kwaye le ndawo ene-acidic inceda ii-capsules ze-HPMC zidibanise. Ngexesha elifanayo, ukushisa okuqhelekileyo komzimba womntu (37 ° C) kunokukhuthaza ukuchithwa ngokukhawuleza kwee-capsules. Ke ngoko, kwindawo ye-asidi yesisu, ii-capsules ze-HPMC zinokunyibilika ngokukhawuleza kwaye zikhulule imixholo yazo.
HPMC capsule eludongeni ubukhulu kunye noxinaniso
Ubunzima bodonga lwe-capsule luchaphazela ngokuthe ngqo ixesha lokuchithwa. Iindonga ze-capsule ezityebileyo zithatha ixesha elingakumbi ukunyibilika ngokupheleleyo, ngelixa iindonga ezincinci ze-capsule zinyibilika ngokukhawuleza. Ukongeza, ubuninzi be-capsule ye-HPMC buya kuchaphazela izinga lokuchithwa kwayo. Ii-capsules ezixineneyo ziya kuthatha ixesha elide ukuba ziphule esiswini.
Uhlobo kunye nohlobo lwesiqulatho
Izithako ezilayishwe ngaphakathi kwe-capsule nazo zinefuthe elithile kwizinga lokuchithwa. Ngokomzekelo, ukuba iziqulatho zine-acidic okanye i-soluble, i-capsule iya kuchithwa ngokukhawuleza kwisisu; ngelixa kwezinye izithako ezinamafutha, kungathatha ixesha elide ukudilika. Ukongeza, izinga lokuchithwa kwezinto ezinomgubo kunye ne-liquid nazo zihluke. Ukuhanjiswa kwemixholo yolwelo kufana ngakumbi, okubangela ukuqhekeka okukhawulezayo kwee-capsules ze-HPMC.
Ubungakanani beCapsule
HPMCii-capsules zeenkcukacha ezahlukeneyo (ezifana neNombolo ye-000, iNo. Ngokuqhelekileyo, ii-capsules ezincinci zithatha ixesha elifutshane ukunyibilika, ngelixa ii-capsules ezinkulu zineendonga ezityebileyo kunye neziqulatho ezininzi, ngoko zithatha ixesha elide ukunyibilika.
Inkqubo yokulungiselela
Ngexesha lenkqubo yokuveliswa kwee-capsules ze-HPMC, ukuba i-plasticizers isetyenziswe okanye ezinye izithako zongezwa, iimpawu zokuchithwa kwee-capsules zingatshintshwa. Ngokomzekelo, abanye abavelisi bongeza i-glycerin yemifuno okanye ezinye izinto kwi-HPMC ukunyusa ukuqina kwee-capsules, ezinokuchaphazela izinga lokuqhekeka kwee-capsules ukuya kwinqanaba elithile.
Ukufuma kunye neemeko zokugcina
Iipilisi ze-HPMC zinovakalelo kumswakama kunye neemeko zokugcina. Ukuba igcinwe kwindawo eyomileyo okanye ephezulu yokushisa, ii-capsules zinokuthi zibe brittle, ngaloo ndlela zitshintshe izinga lokuchithwa kwisisu somntu. Ngoko ke, ii-capsules ze-HPMC ngokuqhelekileyo kufuneka zigcinwe kwindawo yokushisa ephantsi kunye neyomileyo ukuze kuqinisekiswe ukuzinza kwezinga lokuchithwa kwazo kunye nomgangatho.
3. Inkqubo yokuchithwa kwee-capsules ze-HPMC
Inkqubo yokuchithwa kwee-capsules ze-HPMC yahlulwe ngokubanzi ngokwezigaba ezithathu:
Inqanaba lokuqala lokufunxa amanzi: Emva kokufunxa, ii-capsules ze-HPMC kuqala ziqala ukufunxa amanzi kwijusi yesisu. Umphezulu we-capsule uba manzi kwaye ngokuthe ngcembe uqala ukuthamba. Ekubeni ukwakhiwa kwee-capsules ze-HPMC kunomlinganiselo othile wokufunxa kwamanzi, eli nqanaba lidla ngokukhawuleza.
Ukudumba kunye nenqanaba lokuqhekeka: Emva kokufunxa amanzi, udonga lwe-capsule ludumba ngokuthe ngcembe ukwenza i-gelatinous layer. Olu luhlu lubangela ukuba i-capsule iqhube ngakumbi, kwaye iziqulatho ziyavezwa kwaye zikhutshwe. Eli nqanaba limisela izinga lokuchithwa kwe-capsule kwaye liyisitshixo sokukhululwa kweziyobisi okanye izondlo.
Inqanaba elipheleleyo lokuchithwa: Njengoko ukuchithwa kuqhubela phambili, i-capsule ichithwa ngokupheleleyo, iziqulatho zikhutshwe ngokupheleleyo, kwaye zinokuthi zifakwe ngumzimba womntu. Ngokwesiqhelo kwimizuzu eli-10 ukuya kwengama-30, ii-capsules ze-HPMC zinokugqiba inkqubo ukusuka ekuqhekekeni ukuya ekupheliseni.
Inkqubo yokulungiselela
Ngexesha lenkqubo yokuveliswa kwee-capsules ze-HPMC, ukuba i-plasticizers isetyenziswe okanye ezinye izithako zongezwa, iimpawu zokuchithwa kwee-capsules zingatshintshwa. Ngokomzekelo, abanye abavelisi bongeza i-glycerin yemifuno okanye ezinye izinto kwi-HPMC ukunyusa ukuqina kwee-capsules, ezinokuchaphazela izinga lokuqhekeka kwee-capsules ukuya kwinqanaba elithile.
Ukufuma kunye neemeko zokugcina
Iipilisi ze-HPMC zinovakalelo kumswakama kunye neemeko zokugcina. Ukuba igcinwe kwindawo eyomileyo okanye ephezulu yokushisa, ii-capsules zinokuthi zibe brittle, ngaloo ndlela zitshintshe izinga lokuchithwa kwisisu somntu. Ngoko ke, ii-capsules ze-HPMC ngokuqhelekileyo kufuneka zigcinwe kwindawo yokushisa ephantsi kunye neyomileyo ukuze kuqinisekiswe ukuzinza kwezinga lokuchithwa kwazo kunye nomgangatho.
3. Inkqubo yokuchithwa kwee-capsules ze-HPMC
Inkqubo yokuchithwa kwee-capsules ze-HPMC yahlulwe ngokubanzi ngokwezigaba ezithathu:
Inqanaba lokuqala lokufunxa amanzi: Emva kokufunxa, ii-capsules ze-HPMC kuqala ziqala ukufunxa amanzi kwijusi yesisu. Umphezulu we-capsule uba manzi kwaye ngokuthe ngcembe uqala ukuthamba. Ekubeni ukwakhiwa kwee-capsules ze-HPMC kunomlinganiselo othile wokufunxa kwamanzi, eli nqanaba lidla ngokukhawuleza.
Ukudumba kunye nenqanaba lokuqhekeka: Emva kokufunxa amanzi, udonga lwe-capsule ludumba ngokuthe ngcembe ukwenza i-gelatinous layer. Olu luhlu lubangela ukuba i-capsule iqhube ngakumbi, kwaye iziqulatho ziyavezwa kwaye zikhutshwe. Eli nqanaba limisela izinga lokuchithwa kwe-capsule kwaye liyisitshixo sokukhululwa kweziyobisi okanye izondlo.
Inqanaba elipheleleyo lokuchithwa: Njengoko ukuchithwa kuqhubela phambili, i-capsule ichithwa ngokupheleleyo, iziqulatho zikhutshwe ngokupheleleyo, kwaye zinokuthi zifakwe ngumzimba womntu. Ngokwesiqhelo kwimizuzu eli-10 ukuya kwengama-30, ii-capsules ze-HPMC zinokugqiba inkqubo ukusuka ekuqhekekeni ukuya ekupheliseni.
Ixesha lokuposa: Nov-07-2024