I-HPMC (i-hydroxypropyl methylcellulose) i-thickener kunye ne-stabilizer esetyenziswa ngokuqhelekileyo kwizinto zokwakha, iingubo, amayeza kunye nokutya. I-HPMC 15 cps ithetha ukuba i-viscosity yayo yi-15 centipoise, ibakala eliphantsi le-viscosity.
1. Ukwandisa uxinzelelo lwe-HPMC
Eyona ndlela ichanekileyo kunye nesebenzayo yokwandisa i-viscosity ye-HPMC kukwandisa ukugxila kwayo kwisisombululo. Xa iqhezu lobunzima be-HPMC linyuka, i-viscosity yesisombululo nayo iya kwanda. Ingundoqo yale ndlela kukuba i-HPMC ikwandisa i-viscosity yesisombululo ngokwenza isakhiwo sothungelwano esine-ntathu-dimensional. Njengoko inani leemolekyuli ze-HPMC kwisisombululo sanda, ukuxinana kunye namandla esakhiwo sothungelwano kuya kwanda, ngaloo ndlela kwandisa i-viscosity yesisombululo. Nangona kunjalo, kukho umda wokwandisa ugxininiso. Ukuxinana okuphezulu kakhulu kwe-HPMC kuya kubangela ukuncipha kwesisombululo, kwaye kunokuchaphazela nokusebenza kwayo kwizicelo ezithile, ezinjengokwakha kunye nokusebenza.
2. Lawula ubushushu besisombululo
Ubushushu bunempembelelo enkulu kwi-solubility kunye ne-viscosity ye-HPMC. Kwiqondo lokushisa eliphantsi, i-viscosity yesisombululo se-HPMC iphezulu; ngelixa kubushushu obuphezulu, i-viscosity yesisombululo se-HPMC iya kuncipha. Ngoko ke, ukunciphisa ubushushu besisombululo ngokufanelekileyo ngexesha lokusetyenziswa kunokunyusa i-viscosity ye-HPMC. Kufuneka kuqatshelwe ukuba i-solubility ye-HPMC kwisisombululo iyahluka kumaqondo okushisa ahlukeneyo. Ngokuqhelekileyo kulula ukusabalalisa emanzini abandayo, kodwa kuthatha ixesha elithile ukuchithwa ngokupheleleyo. Ichithwa ngokukhawuleza emanzini afudumeleyo, kodwa i-viscosity iphantsi.
3. Guqula ixabiso le-pH le-solvent
I-viscosity ye-HPMC nayo inovakalelo kwixabiso le-pH yesisombululo. Ngaphantsi kweemeko ezingathathi hlangothi okanye ezikufutshane, i-viscosity yesisombululo se-HPMC iyona nto iphezulu. Ukuba ixabiso le-pH lesisombululo liyaphambuka ekungathathi hlangothi, i-viscosity inokuncipha. Ngoko ke, i-viscosity yesisombululo se-HPMC inokunyuswa ngokulungelelanisa ngokufanelekileyo ixabiso le-pH yesisombululo (umzekelo, ngokongeza i-buffer okanye i-acid-base regulator). Nangona kunjalo, ekusebenzeni okwenyani, uhlengahlengiso lwexabiso le-pH kufuneka lulumke kakhulu, kuba utshintsho olukhulu lunokubangela ukuthotywa kwe-HPMC okanye ukuthotywa kokusebenza.
4. Khetha isinyibilikisi esifanelekileyo
I-solubility kunye ne-viscosity ye-HPMC kwiinkqubo ezahlukeneyo zokunyibilikisa zahlukile. Nangona i-HPMC isetyenziswa ikakhulu kwizisombululo ezinamanzi, ukongezwa kwezinye izinyibilikisi zendalo (ezifana ne-ethanol, isopropanol, njl.) Ngokomzekelo, inani elincinci le-solvent ye-organic linganciphisa ukuphazamiseka kwama-molecule amanzi kwi-HPMC, ngaloo ndlela ikhulise i-viscosity yesisombululo. Kwimisebenzi ethile, kuyimfuneko ukukhetha i-solvents efanelekileyo ye-organic ngokwesicelo sangempela.
5. Sebenzisa izixhobo zokujiya
Kwezinye iimeko, ezinye izixhobo ezityebisayo zingongezwa kwi-HPMC ukuphumeza umphumo wokwandisa i-viscosity. Ngokuqhelekileyo ezisetyenziselwa ukutyebisa zibandakanya xanthan gum, guar gum, carbomer, njl. Ezi zongezo zisebenzisana neemolekyuli zeHPMC ukwenza ijeli eyomeleleyo okanye isakhiwo sothungelwano, ngakumbi ukwandisa i-viscosity yesisombululo. Ngokomzekelo, i-xanthan gum yi-polysaccharide yendalo kunye nefuthe eliqinileyo lokuqina. Xa isetyenziswe kunye ne-HPMC, ezi zimbini zingenza i-synergistic effect kwaye zandise kakhulu i-viscosity yenkqubo.
6. Guqula iqondo lokutshintshwa kwe-HPMC
I-viscosity ye-HPMC nayo inxulumene neqondo lokuthatha indawo ye-methoxy kunye namaqela e-hydroxypropoxy. Iqondo lokutshintshwa lichaphazela ukunyibilika kwayo kunye ne-viscosity yesisombululo. Ngokukhetha i-HPMC enemigangatho eyahlukeneyo yokutshintsha, i-viscosity yesisombululo inokulungiswa. Ukuba i-viscosity ephezulu ye-HPMC iyadingeka, imveliso enomxholo ophezulu we-methoxy inokukhethwa, kuba iphakamileyo umxholo we-methoxy, i-hydrophobicity ye-HPMC inamandla, kwaye i-viscosity emva kokuchithwa iphezulu.
7. Yandisa ixesha lokupheliswa
Ixesha apho i-HPMC inyibilika nayo iya kuchaphazela i-viscosity yayo. Ukuba i-HPMC ayichithwanga ngokupheleleyo, i-viscosity yesisombululo ayiyi kufikelela kwindawo efanelekileyo. Ngoko ke, ukwandisa ngokufanelekileyo ixesha lokuchithwa kwe-HPMC emanzini ukuqinisekisa ukuba i-HPMC ifakwe ngokupheleleyo emanzini inokunyusa ngokufanelekileyo i-viscosity yesisombululo sayo. Ingakumbi xa inyibilika kumaqondo obushushu aphantsi, inkqubo yokupheliswa kwe-HPMC inokucotha, kwaye ukwandisa ixesha kubalulekile.
8. Guqula iimeko zokucheba
I-viscosity ye-HPMC ikwanxulumene namandla okucheba ephantsi kwayo ngexesha lokusetyenziswa. Ngaphantsi kweemeko eziphezulu zokucheba, i-viscosity yesisombululo se-HPMC iya kuncipha okwethutyana, kodwa xa i-shear iyeka, i-viscosity iya kubuyiselwa. Kwiinkqubo ezifuna ukunyuka kwe-viscosity, i-shear force apho isisombululo sixhomekeke khona sinokuncitshiswa, okanye sinokusebenza phantsi kweemeko eziphantsi zokucheba ukuze kugcinwe i-viscosity ephezulu.
9. Khetha ubunzima obufanelekileyo bemolekyuli
Ubunzima bemolekyuli ye-HPMC ichaphazela ngqo i-viscosity yayo. I-HPMC enobunzima obukhulu bemolekyuli yenza ulwakhiwo lwenethiwekhi enkulu kwisisombululo, okukhokelela kwi-viscosity ephezulu. Ukuba ufuna ukwandisa i-viscosity ye-HPMC, ungakhetha iimveliso ze-HPMC ezinobunzima obuphezulu be-molecular. Nangona i-HPMC 15 cps iyimveliso ye-viscosity ephantsi, i-viscosity inokunyuswa ngokukhetha i-high-molecular-weight-weight yemveliso efanayo.
10. Qwalasela iimeko zokusingqongileyo
Izinto zokusingqongileyo ezifana nokufuma kunye noxinzelelo nazo zinokuba nefuthe elithile kwi-viscosity yesisombululo se-HPMC. Kwindawo yokufuma okuphezulu, i-HPMC inokufunxa ukufuma emoyeni, ibangele ukuba i-viscosity yayo yehle. Ukuze ugweme oku, iimeko zokusingqongileyo zemveliso okanye ukusetyenziswa kwendawo zingalawulwa ngokufanelekileyo ukugcina indawo eyomileyo kunye noxinzelelo olufanelekileyo lokugcina i-viscosity yesisombululo se-HPMC.
Zininzi iindlela zokwandisa i-viscosity yesisombululo se-HPMC 15 cps, kubandakanya ukwanda koxinaniso, ukulawula ubushushu, ukulungisa i-pH, ukusebenzisa izixhobo zokuncedisa ukutyeba, ukukhetha iqondo elifanelekileyo lokutshintshwa kunye nobunzima bemolekyuli, njl. Imeko kunye neemfuno zenkqubo. Kumsebenzi wokwenyani, kudla ngokuba yimfuneko ukuba kuqwalaselwe ngokubanzi izinto ezininzi kwaye wenze uhlengahlengiso olufanelekileyo kunye nokulungelelaniswa kokuqinisekisa ukusebenza kakuhle kwesisombululo se-HPMC kwizicelo ezithile.
Ixesha lokuposa: Oct-16-2024