I-Hydroxypropyl methylcellulose (HPMC), njenge-derivative cellulose derivative, isetyenziswa ngokubanzi kulwakhiwo, amayeza, ukutya, iikhemikhali zemihla ngemihla kunye namanye amashishini. Umgangatho we-HPMC ugwetywa ikakhulu kwimiba yeempawu zomzimba kunye neekhemikhali, ukusebenza okusebenzayo kunye nesiphumo sokusetyenziswa.
1. Imbonakalo kunye nombala
I-HPMC idla ngokuba ngumgubo omhlophe okanye ongekho-mhlophe okanye iigranules. Ukuba kukho utshintsho oluphawulekayo lombala, njenge-yellowing, graying, njl., kunokuthetha ukuba ubunyulu bayo abukho phezulu okanye bungcolile. Ukongezelela, ukufana kwesayizi ye-particle kuphinda kubonisa inqanaba lokulawula inkqubo yokuvelisa. Amasuntswana HPMC Good kufuneka isasazwe ngokulinganayo ngaphandle agglomeration ezicacileyo okanye ukungcola.
2. Uvavanyo lokunyibilika
I-HPMC inokunyibilika kakuhle kwamanzi, nto leyo isalathiso esibalulekileyo sokugweba umgangatho wayo. Ngovavanyo olulula lokuchithwa, ukunyibilika kwayo kunye ne-viscosity kunokuhlolwa. La manyathelo alandelayo:
Thatha umgubo omncinci we-HPMC, udibanise ngokuthe ngcembe emanzini abandayo okanye ubushushu begumbi, kwaye ujonge inkqubo yayo yokupheliswa. Umgangatho ophezulu we-HPMC kufuneka usasazwe ngokulinganayo ngexesha elifutshane ngaphandle kwemvula ecacileyo ye-flocculent, kwaye ekugqibeleni yenze isisombululo se-colloidal esicacileyo okanye esincinci.
Ireyithi yokuchithwa kwe-HPMC inxulumene nesakhiwo sayo semolekyuli, iqondo lokutshintshwa, kunye nenkqubo yococeko. Umgangatho ophantsi we-HPMC unokunyibilika kancinane kwaye ngokulula wenze amahlwili ekunzima ukubola.
3. Umlinganiselo we-Viscosity
I-Viscosity yenye yezona parameters zibaluleke kakhulu kumgangatho we-HPMC. I-viscosity yayo emanzini ichaphazeleka ubunzima be-molecular kunye neqondo lokutshintshwa, kwaye ngokuqhelekileyo ilinganiswa ne-viscometer ejikelezayo okanye i-capillary viscometer. Indlela ethile kukuchitha umlinganiselo othile we-HPMC emanzini, ulungiselele isisombululo soxinaniso oluthile, uze ulinganise i-viscosity yesisombululo. Ngokwedatha ye-viscosity, kunokugwetywa ukuba:
Ukuba ixabiso le-viscosity liphantsi kakhulu, linokuthetha ukuba ubunzima be-molecular buncinci okanye buhlanjululwe ngexesha lenkqubo yokuvelisa;
Ukuba ixabiso le-viscosity liphezulu kakhulu, linokuthetha ukuba ubunzima be-molecular bukhulu kakhulu okanye ukutshintshwa akulingani.
4. Ukubona ubunyulu
Ukucoceka kwe-HPMC kuya kuchaphazela ngokuthe ngqo ukusebenza kwayo. Iimveliso ezinobunyulu obuphantsi zihlala zineentsalela ezininzi okanye ukungcola. Isigwebo sokuqala sinokwenziwa ngezi ndlela zilula zilandelayo:
Uvavanyo lwentsalela ekutshisweni: Beka isampuli encinci ye-HPMC kwiziko lobushushu obuphezulu kwaye uyitshise. Ubungakanani bentsalela ingabonakalisa umxholo weetyuwa ezingaphiliyo kunye neeyoni zetsimbi. Iintsalela ze-HPMC ezikumgangatho ophezulu kufuneka zibe zincinci kakhulu.
Uvavanyo lwexabiso le-pH: Thatha isixa esifanelekileyo se-HPMC kwaye uyinyibilikise emanzini, kwaye usebenzise iphepha lovavanyo lwe-pH okanye imitha ye-pH ukulinganisa ixabiso le-pH yesisombululo. Phantsi kweemeko eziqhelekileyo, isisombululo samanzi se-HPMC kufuneka sisondele ekungathathi hlangothi. Ukuba i-acidic okanye i-alkaline, ukungcola okanye iimveliso eziphumayo zinokubakho.
5. Iimpawu ze-thermal kunye nokuzinza kwe-thermal
Ngokufudumeza isampuli ye-HPMC, ukuzinza kwayo kwe-thermal kunokubonwa. Umgangatho ophezulu we-HPMC kufuneka ube nokuzinza okuphezulu kwe-thermal ngexesha lokufudumeza kwaye akufanele ukubola okanye ukusilela ngokukhawuleza. Amanyathelo alula okuvavanya ukusebenza kwe-thermal abandakanya:
Fudumeza isampulu encinci kwipleyiti eshushu kwaye ujonge indawo yayo yokunyibilika kunye nobushushu bokubola.
Ukuba isampuli iqala ukubola okanye ukutshintsha umbala kwiqondo lokushisa eliphantsi, kuthetha ukuba ukuzinza kwayo kwe-thermal kubi.
6. Ukuzimisela komxholo wokufuma
Isiqulatho sokufuma esiphezulu kakhulu se-HPMC siya kuchaphazela uzinzo kunye nokusebenza kwayo kogcino. Ubumanzi bayo bunokumiselwa ngokwendlela yobunzima:
Beka isampuli ye-HPMC kwi-oveni kwaye uyomise kwi-105 ℃ ukuya kubunzima obungaguqukiyo, emva koko ubale umahluko wobunzima ngaphambi nasemva kokumisa ukufumana umxholo wokufuma. Umgangatho ophezulu we-HPMC kufuneka ube nobumanzi obuphantsi, obudla ngokulawulwa ngaphantsi kwe-5%.
7. Iqondo lokubhaqwa kokutshintshwa
Iqondo lokutshintshwa kwamaqela e-methoxy kunye ne-hydroxypropoxy ye-HPMC ichaphazela ngokuthe ngqo ukusebenza kwayo, njengokunyibilika, ubushushu be-gel, i-viscosity, njl njl. yenziwe kwindawo yelabhoratri. Ngokufutshane, i-HPMC enokutshintshwa okuphantsi inokunyibilika okulambathayo kwaye inokwenza iijeli ezingalinganiyo emanzini.
8. Uvavanyo lobushushu be-gel
Ubushushu bejeli ye-HPMC liqondo lobushushu apho yenza ijeli ngexesha lokufudumeza. Umgangatho ophezulu we-HPMC unoluhlu oluthile lobushushu bejeli, ngokuqhelekileyo phakathi kwe-60°C kunye ne-90°C. Indlela yokuvavanya ubushushu bejeli yile:
Dibanisa HPMC emanzini, ngokuthe ngcembe ukwandisa iqondo lobushushu, kwaye bajonge iqondo lobushushu apho isisombululo sitshintsha ukusuka elubala ukuya turbid, nto leyo iqondo lobushushu gel. Ukuba iqondo lokushisa le-gel liyaphambuka kuluhlu oluqhelekileyo, kunokuthetha ukuba isakhiwo sayo se-molecular okanye idigri yokutshintshwa ayihambelani nomgangatho.
9. Uvandlakanyo lwentsebenzo
Ukusebenza kwesicelo se-HPMC ngeenjongo ezahlukeneyo kunokwahluka. Ngokomzekelo, kushishino lokwakha, i-HPMC isoloko isetyenziswa njenge-arhente yokugcina amanzi kunye ne-thickener. Ukusebenza kwayo kokugcina amanzi kunye nesiphumo sokuqina kunokuvavanywa ngodaka okanye iimvavanyo zeputty. Kumashishini amayeza kunye nokutya, i-HPMC isetyenziswa njengefilimu yangaphambili okanye imathiriyeli ye-capsule, kwaye ifilimu yokwenza ifilimu kunye neempawu ze-colloidal zinokuvavanywa ngokuvavanywa.
10. Ivumba kunye nezinto eziguquguqukayo
Umgangatho ophezulu we-HPMC kufuneka ube nevumba elibonakalayo. Ukuba isampuli inevumba elibi okanye incasa yangaphandle, kunokuthetha ukuba iikhemikhali ezingafunekiyo zaziswa ngexesha lenkqubo yokuvelisa okanye iqulethe izinto eziguquguqukayo kakhulu. Ukongeza, umgangatho ophezulu we-HPMC akufanele uvelise iigesi ezicaphukisayo kumaqondo aphezulu.
Umgangatho we-HPMC unokugwetywa ngovavanyo olulula lomzimba olufana nenkangeleko, ukunyibilika kunye nomlinganiselo we-viscosity, okanye ngeendlela zeekhemikhali ezifana novavanyo lokucoceka kunye nokuvavanya ukusebenza kwe-thermal. Ngezi ndlela, isigwebo sokuqala sinokwenziwa kumgangatho we-HPMC, ngaloo ndlela iqinisekisa ukusebenza kwayo okuzinzile kwizicelo zangempela.
Ixesha lokuposa: Sep-25-2024