I-HPMC ibizwa ngokuba yi-hydroxypropyl methylcellulose.
Imveliso ye-HPMC ikhetha i-cellulose yomqhaphu esulungekileyo njengesixhobo ekrwada kwaye yenziwe nge-etherification ekhethekileyo phantsi kweemeko zealkali. Yonke le nkqubo igqitywe phantsi kweemeko ze-GMP kunye nokubeka iliso ngokuzenzekelayo, ngaphandle kwezithako ezisebenzayo ezifana nezitho zezilwanyana kunye negrisi.
Iimpawu zeHPMC:
Imveliso ye-HPMC yi-ether ye-cellulose engeyo-ionic, imbonakalo ngumgubo omhlophe, ongenavumba, unyibilika emanzini kunye nezinyibiliki ezininzi ze-polar eziphilayo (ezifana ne-dichloroethane) kunye nomlinganiselo ofanelekileyo we-ethanol / amanzi, i-propyl alcohol / amanzi, njl. umsebenzi, ukukhanya okuphezulu kunye nokusebenza okuzinzileyo. I-HPMC ineempawu zejeli ye-thermal, isisombululo samanzi semveliso sifudunyezwa ukwenza i-gel precipitation, kwaye emva koko inyibilika emva kokupholisa, imilinganiselo eyahlukeneyo yobushushu bejeli yemveliso yahlukile. Utshintsho lwe-Solubility kunye ne-viscosity, i-viscosity ephantsi, i-solubility enkulu, iinkcukacha ezahlukeneyo ze-HPMC inomahluko othile kwiipropati zayo, i-HPMC emanzini ayichaphazeli ngexabiso le-PH. Ubungakanani besuntswana: Ireyithi yokupasa ngemesh eyi-100 inkulu kune-100%. Ubuninzi bobuninzi: 0.25-0.70g / (ngokuqhelekileyo malunga ne-0.5g /), ubunzima obuthile 1.26-1.31. Ubushushu bokutshintsha umbala: 190-200℃, ubushushu becarbonization: 280-300℃. Uxinzelelo lomphezulu: 42-56dyn / cm kwi-2% isisombululo samanzi. Ngokunyuka komxholo we-methoxyl, i-gel point iyancipha, i-solubility yamanzi yanda, kunye nomsebenzi we-surface wanda. I-HPMC ineempawu zokuqina, ukutyumba, umxholo wothuthu oluphantsi, ukuzinza kwe-PH, ukugcinwa kwamanzi, ukuzinza kwe-dimensional, ukubunjwa kwefilimu egqwesileyo kunye nokuchasana okubanzi kwi-enzyme, ukusabalalisa kunye nokubambisana.
Usetyenziso lwe-HPMC:
1. Itheyibhile yokwaleka: I-HPMC esetyenziswe njengezinto zokugquma ifilimu ekulungiseleleni okuqinileyo, inokwenza ifilimu eqinile, egudileyo kunye nenhle, ukusetyenziswa koxinzelelo lwe-2% -8%. Emva kokugquma, ukuzinza kwe-arhente ekukhanyeni, ukushisa kunye nomswakama kwanda; Ayinancasa kwaye ayinavumba, kulula ukuyithatha, kunye ne-HPMC pigment, i-sunscreen, izithambiso kunye nokunye ukuhambelana kakuhle kwemathiriyeli. Ukwaleka eqhelekileyo: amanzi okanye 30-80% ethanol ukunyibilika HPMC, kunye nesisombululo 3-6%, ukongeza izithako ezincedisayo (ezifana: ubushushu bomhlaba -80, ioli castor, PEG400, talc, njl.).
2. Umaleko wokwahlula we-Enteric-soluble: kumphezulu wamacwecwe kunye neegranules, i-HPMC yokwaleka isetyenziswa okokuqala njengomaleko wokwahlula ophantsi, ize igqunywe ngoluhlu lwe-HPMCP enyibilikayo kwi-enteric. Ifilimu ye-HPMC inokuphucula ukuzinza kwe-enteric-soluble arhente yokwambathisa kwindawo yokugcina.
3. Ukulungiswa kokukhululwa okuzinzileyo: ukusebenzisa i-HPMC njenge-agent e-pore-inducing kunye nokuxhomekeka kwi-ethyl cellulose njenge-skeleton material, iipilisi ezihlala ixesha elide ezikhutshwayo zingenziwa.
4. I-arhente yokuqina kunye ne-adhesive colloid ekhuselayo kunye ne-eye drops: I-HPMC ye-agent yokuqina esetyenziswa rhoqo kwi-concentration ye-0.45-1%.
5. I-Adhesive: I-HPMC njenge-binder general concentration ye-2% -5%, esetyenziselwa ukuphucula ukuzinza kwe-hydrophobic adhesive, i-concentration esetyenziswa ngokuqhelekileyo ye-0.5-1.5%.
6. I-arhente yokulibazisa, i-arhente yokukhululwa elawulwayo kunye ne-arhente yokumiswa. I-arhente yokumisa: i-dosage eqhelekileyo ye-arhente yokumisa i-0.5-1.5%.
7. Ukutya: I-HPMC njenge-ejenti yokuqina eyongeziweyo kwiintlobo ezahlukeneyo zeziselo, iimveliso zobisi, i-condiments, ukutya okunesondlo, njenge-agent ekhulayo, i-binder, i-emulsifier, i-agent yokunqunyanyiswa, i-stabilizer, i-arhente yokugcina amanzi, i-excifer, njl.
8. Isetyenziswe kwi-cosmetics njenge-adhesives, i-emulsifiers, i-film forming agents, njl.
Ixesha lokuposa: Jan-14-2022