I-HPMC ibizwa ngokuba yi-hydroxypropyl methylcellulose.
Imveliso ye-HPMC ikhetha i-cellulose yomqhaphu esulungekileyo njengemathiriyeli ekrwada kwaye yenziwa yi-etherification ekhethekileyo phantsi kweemeko zealkali.Yonke le nkqubo igqitywe phantsi kweemeko ze-GMP kunye nokubeka iliso ngokuzenzekelayo, ngaphandle kwezithako ezisebenzayo ezifana nezitho zezilwanyana kunye negrisi.
Iimpawu zeHPMC:
Imveliso ye-HPMC yi-ether ye-cellulose engeyo-ionic, imbonakalo ingumgubo omhlophe, ingenavumba, i-soluble emanzini kunye nezinyibiliki ezininzi ze-polar eziphilayo (ezifana ne-dichloroethane) kunye nomlinganiselo ofanelekileyo we-ethanol / amanzi, i-propyl alcohol / amanzi, njl. umsebenzi, ukukhanya okuphezulu kunye nokusebenza okuzinzileyo.I-HPMC ineempawu zejeli ye-thermal, isisombululo samanzi semveliso sifudunyezwa ukwenza i-gel precipitation, kwaye emva koko inyibilika emva kokupholisa, imilinganiselo eyahlukeneyo yobushushu bejeli yemveliso yahlukile.Utshintsho lwe-Solubility kunye ne-viscosity, i-viscosity ephantsi, i-solubility enkulu, inkcazo eyahlukileyo ye-HPMC inomahluko othile kwiipropati zayo, i-HPMC emanzini ayichaphazeli ngexabiso le-PH.Ubungakanani besuntswana: Ireyithi yokupasa ngemesh eyi-100 inkulu kune-100%.Ubuninzi bobuninzi: 0.25-0.70g / (ngokuqhelekileyo malunga ne-0.5g /), ubunzima obuthile 1.26-1.31.Ubushushu bokutshintsha umbala: 190-200℃, ubushushu becarbonization: 280-300℃.Uxinzelelo lomphezulu: 42-56dyn / cm kwi-2% isisombululo samanzi.Ngokunyuka komxholo we-methoxyl, i-gel point iyancipha, i-solubility yamanzi yanda, kunye nomsebenzi we-surface wanda.I-HPMC ineempawu zokuqina, ukutyumba, umxholo wothuthu oluphantsi, ukuzinza kwe-PH, ukugcinwa kwamanzi, ukuzinza kwe-dimensional, ifilimu ebalaseleyo yokwenza kunye nokuchasana okubanzi kwi-enzyme, ukusabalalisa kunye nokubambisana.
Usetyenziso lwe-HPMC:
1. Itheyibhile yokwaleka: I-HPMC esetyenziswe njengezinto zokugquma ifilimu ekulungiseleleni okuqinileyo, inokwenza ifilimu eqinile, egudileyo kunye nenhle, ukusetyenziswa koxinzelelo lwe-2% -8%.Emva kokugquma, ukuzinza kwe-arhente ekukhanyeni, ukushisa kunye nomswakama kwanda;Ayinancasa kwaye ayinavumba, kulula ukuyithatha, kunye ne-HPMC pigment, i-sunscreen, izithambiso kunye nokunye ukuhambelana kakuhle kwemathiriyeli.Ukwaleka eqhelekileyo: amanzi okanye 30-80% ethanol ukunyibilika HPMC, kunye 3-6% isisombululo, ukongeza izithako ezincedisayo (ezifana: ubushushu bomhlaba -80, ioli castor, PEG400, talc, njl.).
2. I-Enteric-soluble coating isolation layer: kumphezulu wamacwecwe kunye neegranules, i-HPMC yokugqoka isetyenziselwa kuqala njenge-coating ephantsi yokwehlula umaleko, kwaye emva koko igqunywe ngoluhlu lwe-HPMCP e-enteric-soluble.Ifilimu ye-HPMC inokuphucula ukuzinza kwe-enteric-soluble arhente yokwambathisa kwindawo yokugcina.
3. Ukulungiswa kokukhululwa okuzinzileyo: ukusebenzisa i-HPMC njenge-agent e-pore-inducing kunye nokuxhomekeka kwi-ethyl cellulose njenge-skeleton material, iipilisi ezisebenza ixesha elide zingenziwa.
4. I-agent yokuqina kunye ne-colloid adhesive ekhuselayo kunye ne-eye drops: I-HPMC ye-agent ye-thickening esetyenziswa ngokuqhelekileyo i-concentration ye-0.45-1%.
5. I-Adhesive: I-HPMC njenge-binder general concentration ye-2% -5%, esetyenziselwa ukuphucula ukuzinza kwe-hydrophobic adhesive, i-concentration esetyenziswa ngokuqhelekileyo ye-0.5-1.5%.
6. I-arhente yokulibazisa, i-arhente yokukhululwa elawulwayo kunye ne-arhente yokumiswa.I-arhente yokumisa: i-dosage eqhelekileyo ye-arhente yokumisa i-0.5-1.5%.
7. Ukutya: I-HPMC njenge-ejenti yokuqina yongezwa kwiintlobo ezahlukeneyo zeziselo, iimveliso zobisi, i-condiments, ukutya okunesondlo, njenge-agent eqina, i-binder, i-emulsifier, i-agent yokunqunyanyiswa, i-stabilizer, i-arhente yokugcina amanzi, i-excifer, njl.
8. Isetyenziswe kwi-cosmetics njenge-adhesives, i-emulsifiers, i-film forming agents, njl.
Ixesha lokuposa: Jan-14-2022