IHydroxypropyl methylcellulose inoluhlu olubanzi lweemfuno ze-viscosity kunye nococeko

I-Hydroxypropylmethylcellulose (HPMC) yi-ether ye-cellulose esetyenziswa ngokubanzi kumashishini ahlukeneyo ngenxa yeempawu zayo ezizodwa kunye nokuguquguquka. Ayiyiyo ityhefu, ipholima enyibilikayo emanzini enyibilika kuwo omabini amanzi abandayo nashushu. Yimathiriyeli ekrwada enexabiso ethe yasetyenziswa njenge-thickener, binder, stabilizer, emulsifier, kunye nefilim yangaphambili kwizicelo ezahlukeneyo ezifana neshishini lokutya, amayeza, ulwakhiwo, kunye nezinto zokuthambisa.

Enye yeempawu ezisisiseko ze-HPMC luluhlu lwayo lwe-viscosity ebanzi. I-viscosity ye-HPMC ixhomekeke kwizinto ezininzi ezifana neqondo lokutshintshela, ubunzima bemolekyuli kunye noxinaniso. Ngoko ke, i-HPMC ingasetyenziswa kuluhlu olubanzi lwezicelo ezifuna amanqanaba ahlukeneyo e-viscosity. Umzekelo, i-high-viscosity HPMC iqhele ukusetyenziswa njenge-thickener kunye nokuzinzisa ekutyeni, ngelixa i-HPMC ene-viscosity ephantsi isetyenziswa kushishino lwamayeza njenge-binder kunye ne-tablet coating.

HPMC ubunyulu kwakhona into ebalulekileyo. Ngokuqhelekileyo iza kumabakala ahlukeneyo okucoceka ukusuka kwi-99% ukuya kwi-99.9%. Awona manqaku aphezulu acocekileyo akhethwa ngokubanzi lishishini lamayeza, elinemigaqo engqongqo kumgangatho wezinto eziluhlaza. Ukucoceka okuphezulu kwe-HPMC kunceda ekuqinisekiseni umgangatho obalaseleyo wemveliso yokugqibela. Inqanaba lokucoceka likwachaphazela iipropati ze-HPMC ezifana ne-viscosity, ukunyibilika, kunye ne-gelation. Ngokubanzi, amanqanaba aphezulu okucoceka aphucula iimpawu zokusebenza.

Ukongeza kwi-viscosity kunye nobunyulu, kukho ezinye izinto ezibalulekileyo ekufuneka ziqwalaselwe xa ukhetha i-HPMC efanelekileyo kwisicelo esithile. Ezi ziquka ubungakanani bamasuntswana, indawo engaphezulu, ukufuma kunye neqondo lokutshintsha. Ubungakanani besuntswana kunye nommandla womphezulu we-HPMC unokuchaphazela ukunyibilika kwayo, ngelixa umxholo wokufuma uchaphazela uzinzo kunye nobomi beshelufu. Kubalulekile ukukhetha iqondo elichanekileyo lokutshintsha, okt umlinganiselo ozalanayo we-hydroxypropyl kunye ne-methyl substituents kwi-molecule ye-HPMC. Izinga eliphezulu lokutshintsha linokukhokelela ekunyibilikeni kwamanzi okwandisiweyo kunye ne-viscosity ephuculweyo, ngelixa iidigri ezisezantsi zokutshintsha zingakhokelela ekuphuculweni kweempawu zokwenza ifilimu.

ishishini lokutya

Kushishino lokutya, i-HPMC iqhele ukusetyenziswa njenge-thickener, emulsifier kunye nezinzisi kwiimveliso ezahlukeneyo ezifana neesosi, isuphu, izinxibo, iimveliso zobisi kunye neempahla ezibhakiweyo. I-HPMC iphucula ukuthungwa kokutya ngokubonelela ngokugudileyo, okukhrimu kunye nokuhambelana okufanayo. Kwakhona kunceda ukuthintela izithako ekwahlukaneni, ngaloo ndlela ukwandisa ubomi beshelufa yokutya.

Enye yeempawu ezisisiseko ze-HPMC kwishishini lokutya kukukwazi ukugcina i-viscosity yemveliso kumaqondo obushushu aphezulu, njengaxa upheka kunye nokufakwa kwi-pasteurization. Uzinzo oluphezulu lobushushu be-HPMC luvumela ukuba lusetyenziswe ekutyeni okunobushushu obuphezulu obufana neemveliso ezinkonkxiweyo okanye ezizinzile kwishelufu.

Ishishini lamachiza

Kwishishini lamachiza, i-HPMC isoloko isetyenziswa njenge-binder, i-disintegrant, i-agent yokugqoka i-tablet, i-ejenti yokukhululwa elawulwayo, njl njl kumalungiselelo ahlukeneyo amayeza. I-HPMC ikhethwa ngaphezu kwezinye izinto zokuncamathelisa kuba ayinatyhefu kwaye iyanyibilika emanzini ashushu nabandayo. Ukukwazi ukunyibilika kumanzi ashushu nabandayo kubaluleke kakhulu kwi-granulation emanzi, indlela eqhelekileyo yokuvelisa iipilisi.

I-HPMC ikwasetyenziswa njenge-disintegrant kwiipilisi. Inceda ukuqhekeza iipilisi zibe ngamaqhekeza amancinci, okuphucula isantya apho iyeza lifunxwa khona emzimbeni. Ukongeza, i-HPMC isoloko isetyenziswa njenge-arhente yokugquma ngenxa yeempawu zayo zokwenza ifilim. Ikhusela ithebhulethi kwizinto ezisingqongileyo, ngaloo ndlela yandisa ubomi beshelufu.

melana

Kushishino lokwakha, i-HPMC isetyenziselwa ukuphucula ukusebenza kunye nokusebenza kweemveliso ezahlukeneyo zesamente ezifana nodaka, iigrouts kunye ne-plasters. I-HPMC isebenza njenge-thickener, iphucula ukunamathela, kwaye ibonelela ngeempawu zokugcina amanzi kumxube. Ukukwazi kwe-HPMC ukwenza ifilimu yokukhusela ikwanceda ukukhusela amanzi ekungeneni kwi-matrix yesamente, ukuphucula ukuqina. I-viscosity ye-HPMC idlala indima ebalulekileyo ekusebenzeni komxube. Ke ngoko, kuxhomekeke kwisicelo, amanqanaba ahlukeneyo e-viscosity ye-HPMC asetyenziswa.

zokuthambisa

Kushishino lwezithambiso, i-HPMC isetyenziswa njenge-thickener, stabilizer, kunye nefilimu yangaphambili kwiimveliso ezahlukeneyo ezifana neshampu, iiconditioners, kunye nezinto zokuthambisa. I-HPMC iphucula ukuthungwa kunye nokungaguquguquki kwezinto zokuthambisa, ibonelela ngokugqibezela okugudileyo, okukhrimu. Kwakhona kuphucula ukuzinza kwemveliso kunye nobomi beshelufu ngokuthintela ukuhlukana kwezithako. Ukongezelela, iipropati zokwenza ifilimu ze-HPMC zibonelela ngomqobo okhuselayo onceda ukugcina umswakama, ngaloo ndlela ukhusela ukoma.

ukuququmbela

IHydroxypropyl methylcellulose inoluhlu olubanzi lweemfuno ze-viscosity kunye nococeko. Yimathiriyeli ekrwada enemisebenzi emininzi esetyenziswa ngokubanzi kumashishini ahlukeneyo afana nokutya, amayeza, ulwakhiwo, kunye nezinto zokuthambisa. Uluhlu olubanzi lwe-viscosity luvumela i-HPMC ukuba isetyenziswe kwizicelo ezahlukeneyo ezifuna amanqanaba ahlukeneyo e-viscosity. Amanqanaba aphezulu okucoceka abalulekile kwishishini lamachiza, elinemimiselo engqongqo kumgangatho wezinto eziluhlaza. I-HPMC ibaluleke kakhulu kumsebenzi weemveliso ezininzi, ngoko ke ukuqwalaselwa kwe-viscosity echanekileyo kunye nenqanaba lokucoceka kubalulekile.