IHydroxypropylmethylcellulose (HPMC) yipolymer eguquguqukayo esetyenziswa ngokubanzi kumashishini ahlukeneyo ngenxa yeempawu zayo ezizodwa. Le khompawundi iphuma kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zezityalo. Ukwenziwa kwe-HPMC kubandakanya ukunyanga i-cellulose ngepropylene oxide ukwazisa amaqela e-hydroxypropyl kunye ne-methyl chloride ukwazisa amaqela e-methyl. I-polymer ephumelayo ibonisa uluhlu olubanzi lwezinto eziphathekayo kunye neekhemikhali, okwenza ukuba zilungele ukusetyenziswa kumayeza, ukwakhiwa, ukutya kunye namanye amashishini.
1. Ubume beMichiza kunye nokwakheka:
I-Hydroxypropyl methylcellulose yi-semi-synthetic polymer ene-complex chemical structure. I-polymer's backbone iqukethe i-cellulose, i-chain chain ye-molecule ye-glucose edityaniswe yi-β-1,4-glycosidic bond. Iqela le-hydroxypropyl liziswa ngokutshintsha iqela le-hydroxyl (-OH) kunye neqela lepropyl, kwaye iqela le-methyl lingeniswa ngendlela efanayo. I-degree of substitution (DS) imele i-avareji yenani le-hydroxypropyl kunye namaqela e-methyl kwiyunithi ye-glucose kwaye ichaphazela ukunyibilika, i-viscosity, kunye neempawu ze-thermal ze-polymer.
2. Ukunyibilika:
Enye yeempawu ezahlukileyo ze-HPMC kukuziphatha kwayo kokupheliswa. Iyanyibilika emanzini abandayo kunye nashushu, ibonelela ngeenzuzo ezizodwa kwiintlobo ezahlukeneyo zezicelo. I-Solubility inokulungiswa ngokulungelelanisa iqondo lokutshintshwa kunye nobunzima bemolekyuli yepolymer. Le propati yenza i-HPMC ibe ngumgqatswa ogqwesileyo kwiinkqubo ezilawulwayo zokuhanjiswa kwechiza, apho izinga lokuchithwa lidlala indima ebalulekileyo ekukhutshweni kwechiza.
3. I-Viscosity:
I-Hydroxypropyl methylcellulose ifumaneka kumanqanaba ahlukeneyo e-viscosity, kuxhomekeke kwizinto ezifana ne-molecular weight, i-degree of substitution, kunye ne-concentration concentration. I-viscosity yezisombululo ze-HPMC ivumela ukuba zisetyenziswe kwizicelo ezininzi zemizi-mveliso, kubandakanywa amayeza, njengama-thickeners kwiifom zedosi yolwelo, kunye nezixhobo zokwenza ifilimu zokwaleka.
4. Ukwenza ifilimu:
Ifilimu yokwenza ifilimu ye-HPMC ibaluleke kakhulu kwizicelo ezifana neengubo zamachiza, apho isetyenziselwa ukubonelela ngoluhlu olukhuselayo lokufihla incasa yamachiza, ukulawula ukukhutshwa kweziyobisi, kunye nokuphucula ukuzinza. Iifilimu ze-HPMC zicacile kwaye ziguquguqukayo, kwaye iipropati zabo zinokulungelelaniswa ngokuhlengahlengisa ugxininiso lwepolymer, ubunzima bemolekyuli kunye nomxholo weplastiki.
5. Ukusebenza kobushushu:
IHydroxypropyl methylcellulose ibonisa uzinzo oluhle lobushushu ngaphakathi koluhlu oluthile lobushushu. Iimpawu ezishushu zichatshazelwa zizinto ezinje ngeqondo lokutshintsha, ubunzima bemolekyuli, kunye nobukho beplastiki. Ezi zakhiwo zenza ukuba i-HPMC ilungele izicelo apho uzinzo lwe-thermal lubaluleke kakhulu, njengokulungiswa kweendlela zokuxuba amayeza ezingevani nobushushu.
6. Biocompatibility:
Kwiinkalo zamachiza kunye ne-biomedical, i-biocompatibility yingqwalasela ebalulekileyo kwizinto ezisetyenziswa kwiinkqubo zokuhanjiswa kweziyobisi. IHydroxypropyl methylcellulose ngokuqhelekileyo ithathwa njengekhuselekile kwaye inokuhambelana kakuhle kwe-biocompatibility. Isetyenziswa ngokubanzi ekuqulunqweni kweefom zedosi yomlomo, izisombululo ze-ophthalmic kunye neenkqubo zokuhanjiswa kweziyobisi ezilawulwayo.
7. Ugcino lwamanzi kunye neempawu zokujiya:
Isakhono se-HPMC sokugcina amanzi kunye nezisombululo ezityebileyo ziyenza ixabiseke kwizinto zokwakha ezifana neemveliso ezisekwe kwisamente. Kwezi zicelo, i-HPMC isebenza njenge-ejenti yokugcina amanzi, iphucula inkqubo kunye nokuthintela ukomiswa kwangaphambili kwezinto. Iipropathi zokujiya zikwasetyenziswa kwiimveliso ezahlukeneyo zokutya ukunyusa ukuthungwa kunye nokuvakala komlomo.
8. Ukuhanjiswa kweziyobisi ezilawulwayo:
Esinye sezicelo ezibalulekileyo ze-hydroxypropyl methylcellulose kukuqulunqa iinkqubo zokuhanjiswa kweziyobisi ezilawulwayo. I-polymer's solubility, viscosity, kunye neempawu zokwenza ifilimu ziququzelela ukukhutshwa okulawulwayo kwamachiza, okwenza ukuba ukuhanjiswa kweziyobisi okuqhubekayo kunye nokujoliswe kuyo. Oku kunenzuzo ngakumbi ekuphuculeni ukuthotyelwa kwesigulane kunye nokunciphisa iziphumo ebezingalindelekanga ezinxulumene nokukhutshwa kwechiza ngokukhawuleza.
9. Uzinzo phantsi kweemeko ezahlukeneyo ze-pH:
I-HPMC ibonisa uzinzo kuluhlu olubanzi lwe-pH, iyenza ilungele ukwakheka okudinga uzinzo phantsi kweemeko ze-asidi okanye zealkaline. Le propati inenzuzo kumachiza kuba ukuxutywa kwamachiza kunokudibana neendawo ezahlukeneyo ze-pH kwindlela yesisu.
10. Iimpawu zeRheological:
Indlela yokuziphatha ye-rheological yezisombululo ze-HPMC ibalulekile kwizicelo apho iipropathi zokuhamba zibaluleke kakhulu, ezifana nokulungiswa kweengubo, izinto zokuncamathelisa kunye neegels. Iimpawu ze-rheological zinokulungelelaniswa ngokulungelelanisa uxinaniso kunye nobunzima bemolekyuli ye-HPMC ukufezekisa iimpawu zokuhamba ezifunekayo kulawulo oluchanekileyo lwe-e.
IHydroxypropyl methylcellulose iye yaba yipolymer eyimfuneko kumashishini ahlukeneyo ngenxa yokudityaniswa kwayo okukodwa kokunyibilika, i-viscosity, isakhono sokwenza ifilimu kunye ne-biocompatibility. Ukuguquguquka kwayo kwenza ukuba ifaneleke kwizicelo ezahlukeneyo, ukusuka kumayeza kunye nezixhobo zokwakha ukuya kukutya kunye nezithambiso. Njengoko abaphandi beqhubeka nokuphonononga iifomyula ezintsha kunye nokusetyenziswa, iipropati ze-hydroxypropyl methylcellulose ngokungathandabuzekiyo ziya kuba negalelo kwinkqubela phambili kwiinkalo ezahlukeneyo, ukuqinisekisa ukubaluleka kwayo okuqhubekayo kwisayensi yezinto kunye neshishini.
Ixesha lokuposa: Jan-10-2024