Ngaba i-hypromellose acid iyaxhathisa?

IHypromellose, ekwabizwa ngokuba yi-hydroxypropyl methylcellulose (HPMC), ayinyangeki ngokwendalo kwi-asidi. Nangona kunjalo, ukuxhathisa kweasidi ye-hypromellose kunokongezwa ngeendlela ezahlukeneyo zokuqulunqa.

IHypromellose iyanyibilika emanzini kodwa ayinyibiliki kangako kwizinyibilikisi zendalo kunye nolwelo olungelulo lwepolar. Ngoko ke, kwiindawo ezine-acidic, ezifana nesisu, i-hypromellose inokunyibilika okanye idumbe ukuya kwinqanaba elithile, kuxhomekeke kwizinto ezifana nokuxinwa kwe-asidi, i-pH, kunye nobude be-exposure.

Ukuphucula ukuxhathisa kwe-asidi ye-hypromellose ekuqulunqweni kwamachiza, iindlela zokugquma kwe-enteric zihlala zisetyenziswa. Iingubo ze-Enteric zisetyenziselwa iipilisi okanye iipilisi zokukhusela kwindawo ene-acidic yesisu kwaye zivumele ukuba zidlule kwindawo engathathi hlangothi yamathumbu amancinci ngaphambi kokukhulula izithako ezisebenzayo.

Iingubo ze-Enteric ngokuqhelekileyo zenziwe kwiipolymers ezichasene ne-asidi yesisu, njenge-cellulose acetate phthalate (CAP), i-hydroxypropyl methylcellulose phthalate (HPMCP), okanye i-polyvinyl acetate phthalate (PVAP). Ezi polymers zenza umqobo okhuselayo ojikeleze ithebhulethi okanye i-capsule, ukuthintela ukuchithwa kwangaphambi kwexesha okanye ukuthotywa kwesisu esiswini.

Isishwankathelo, ngelixa i-hypromellose ngokwayo inganyangeki nge-asidi, ukuxhathisa kwayo kwe-asidi kunokongezwa ngeendlela zokuqulunqa ezifana ne-enteric coating. Ezi ndlela zisetyenziswa ngokuqhelekileyo ekuqulunqweni kwamachiza ukuqinisekisa ukuhanjiswa okusebenzayo kwezithako ezisebenzayo kwindawo ekujoliswe kuyo isenzo emzimbeni.