IHydroxypropyl methylcellulose, eyaziwa njenge-HPMC, i-polymer eguquguqukayo, eneenjongo ezininzi ezinoluhlu olubanzi lwezicelo kumashishini abandakanya ukwakhiwa, amayeza kunye nokutya. I-HPMC yi-ether cellulose, ethetha ukuba ithathwe kwi-cellulose, i-polymer yendalo efumaneka kwizityalo. Yeyona isetyenziswa ngokuqhelekileyo i-cellulose ether ngenxa yeempawu zayo ezizodwa kunye nexabiso eliphantsi.
Ukuchithwa kwe-HPMC kunokuba yinkqubo ekhohlisayo, ngakumbi xa uzama ukufumana isisombululo esilinganayo kwaye esingaguqukiyo. Kweli nqaku, siza kuxubusha ezinye izinto ezibalulekileyo ukuba uqaphele xa ukunyibilika HPMC ukuqinisekisa ukupheliswa ngempumelelo kunye neziphumo ezinqwenelekayo.
1.Ubunyulu be-HPMC
Ukucoceka kwe-HPMC kunokuchaphazela kakhulu ukunyibilika kwayo emanzini kunye nezinye izinyibilikisi. Ngoko ke, kubalulekile ukuqinisekisa ukuba i-HPMC esetyenziswayo ikumgangatho ophezulu kunye nobunyulu. I-HPMC eyosulelwe nezinye izinto ayinakunyibilika ngokufanelekileyo, oko kukhokelela kwizigaqa okanye amaqhuma kwisinyibiliko. Oku kunokuchaphazela ukusebenza ngokubanzi kweemveliso eziqulethe i-HPMC kwaye kunokubangela iingxaki ngexesha lenkqubo yokuvelisa.
2. Inombolo yebhrendi ye-HPMC
I-HPMC ifumaneka kumabakala ahlukeneyo kunye namanqanaba e-viscosity, kunye nebakala ngalinye lenzelwe isicelo esithile. Ibakala le-HPMC elisetyenzisiweyo liya kumisela isixa se-HPMC esifunekayo kunye nobushushu bokupheliswa kwayo. Ngokuxhomekeke kwibakala le-HPMC, ubushushu bokupheliswa kunye nexesha liya kwahluka. Ke ngoko, kubalulekile ukufunda ngononophelo kwaye ulandele imiyalelo yomenzi malunga nesixa se-HPMC esinokusetyenziswa kunye nobushushu obufunekayo ukuze kucinywe okusebenzayo.
3. Isinyibilikisi kunye nobushushu
Ukukhethwa kwe-solvent esetyenzisiweyo kunye neqondo lokushisa lokuchithwa kwe-HPMC zizinto eziphambili ezichaphazela inkqubo yokuchithwa. Amanzi sesona sinyibilikisi sisetyenziswa kakhulu kwi-HPMC, kwaye kubalulekile ukuqinisekisa ukuba amanzi asetyenziswayo akumgangatho ophezulu kwaye akanabumdaka. Amanzi angacocekanga asenokuba nezingcolisi ezinokuchaphazela ukunyibilika kwe-HPMC kunye nomgangatho wemveliso ngokubanzi.
Iqondo lobushushu apho i-HPMC inyibilika khona likwadlala indima ebalulekileyo. I-HPMC inyibilika kakuhle emanzini afudumeleyo, ngokukhethekayo phakathi kwama-80-90 degrees Celsius. Nangona kunjalo, kufuneka kuqatshelwe ukuba izinga lokushisa akufanele libe phezulu kakhulu, ngaphandle koko i-HPMC iya kuhlanjululwa kwaye ihlaziywe, okubangelwa ukuhla kwe-viscosity kunye nokusebenza kakubi. Ngoko ke, kubalulekile ukulawula ngokucophelela ukushisa kwe-solvent ukuqinisekisa ukusebenza okuhambelanayo kunye nokufanelekileyo.
4. Hlanganisa kwaye ugxobhoze
Ukuxuba kunye nokuphazamiseka kubalulekile ukuqinisekisa ukuchithwa okusebenzayo kwe-HPMC. Ukuxubana ngokucokisekileyo kunye nokuphazamiseka kuya kunceda ukudiliza amasuntswana e-HPMC kwaye enze isisombululo esilinganayo nesihambelanayo. Ngoko ke, kubalulekile ukusebenzisa iindlela ezifanelekileyo zokuxuba, ezifana ne-high-shear mixers, ezinceda ukwandisa amandla okuxuba kunye nokuphazamiseka kwisisombululo.
5. Ugxininiso lwesisombululo se-HPMC
Uxinaniso lwe-HPMC kwisisombululo yinto ebalulekileyo ekufuneka iqwalaselwe xa kuchithwa i-HPMC. Ukuba i-concentration ye-HPMC iphezulu kakhulu, inokubangela ukuba i-clumps okanye i-agglomerates yenze kwisisombululo, isenza kube nzima ukufumana isisombululo esifanayo. Ngakolunye uhlangothi, ukuba ugxininiso luphantsi kakhulu, lunokubangela isisombululo esincinci kwaye sisebenze kakubi.
ukuququmbela
I-HPMC yipolymer eguquguqukayo kwaye eguquguqukayo enoluhlu olubanzi lwezicelo kumashishini afana nokwakha, amayeza kunye nokutya. Ukupheliswa kwe-HPMC kunokuba yinkqubo ekhohlisayo, kwaye kubalulekile ukuqwalasela ngenyameko izinto ezinjengobunyulu, ibakala, i-solvent, iqondo lokushisa, ukuxuba, ukuphazamiseka, kunye noxinzelelo lwesisombululo se-HPMC. Ukutshatyalaliswa okuyimpumelelo kunye neziphumo ezinqwenelekayo zinokufezekiswa ngokulandela imiyalelo yomenzi kunye nokulawula ngononophelo ezi zinto.
Ixesha lokuposa: Sep-22-2023