Ngenkqubela phambili eqhubekayo yeshishini kunye nokuphuculwa kwetekhnoloji, ngentshayelelo kunye nokuphuculwa koomatshini bokutshiza abantu basemazweni, itekhnoloji yokutshiza kunye nokuhlaselwa kwe-Play kunye ne-Platiting kunye neTekhnoloji ye-Play kwaye iphuhliswe kakhulu kwilizwe lam kwiminyaka yam yakutshanje. U-Matshini ophuma kumatshini wahlukile kudaka oluqhelekileyo, olufuna ukusebenza okuphezulu kwamanzi, i-flidity efanelekileyo kunye nokuntywila okuthile. Ngokwesiqhelo, i-hydroxypropyl methylcelcelsulose yongezwa kodaka, apho i-Selesese Ether (i-HPMC) yeyona isetyenziswa kakhulu. Imisebenzi ephambili ye-hydroxypropyl methylcelculose hpmc kwi-purmc eharn: Nangona kunjalo, iintsilelo ze-HPMC azinakutyeshelwa. I-HPMC inesiphumo sokungenela umoya, esiya kubangela isiphene sangaphakathi kwaye sinciphise iipropathi zodaka. I-Shandong Chenbang i-Chenbang Chemical Chemical Coul Coul Coul Com., Ltd. ifundwe impembelelo ye-HPMC kwiqondo lokugcina amanzi, ukuxinana, umxholo womatshini we-Hydroxyproplop ye-HPMYLCELCEL ye-HPMCEP kwi-CHMMCEC ye-firrcopc kwinqaku lemicroscopic. .
1. Uvavanyo
1.1 Izinto ezingafunekiyo
Isamente ekhoyo kwi-P.0 42.5 yesamente, amandla ayo angama-28d kunye no-6.9 kunye ne-48.2 MPA ngokwahlukeneyo; Isanti: Chengde Down River River, 40-100 Mesh; I-seluplose ether: Iveliswe nguShandong Chenbang Chemprong Com., Ltd. Amanzi: Ukucoca amanzi empompo.
1.2 Indlela yovavanyo
Ngokwe-JGJ / T 105-2011 Kweli vavanyo, umyinge we-lime wamiselwa kwi-1: 5, ukungqinelana kwalawulwa (93 + 2) mm, kunye ne-ilselose i-Ether yadityaniswa ngaphandle, kwaye isixa esidibeneyo sasisekwe kwi-cessus mass. Iiprogram ezisisiseko zodaka olunjengoxinzelelo olunamanzi, umxholo womoya, ukugcinwa kwamanzi, kunye nokungaguquguquki kuvavanywa ngokubhekisele kwi-JGJ 70-2009 "kwaye umxholo womoya uvavanywa kwaye wabalwa ngokwendlela yobuqhetseba. Ukulungiselela, ukulungiswa okusesikweni kunye nokucinezelwa kwamandla okunyanzeliswa ngokwe-GB / T 17671999 "iindlela zokuvavanya amandla esanti yesanti Ububanzi be-larvae balinganiswa yi-mercury porosimetse. Imodeli ye-Mercury Porosimeter yayingu-Autopore 9500, kwaye udidi lokulinganisa yayi-5.5 NM-360 μm. Zizonke iiseti ezi-4 zenziwa. Umyinge wesanti yayingu-1: 5, i-viscosity ye-HPMC yayiyi-100 ye-HPMC yayiyi-100 ye-i-i-i-DE-S, kunye ne-Dosage 0, i-0,1%, i-0,2%, i-0.3% (B, C, ngokulandelelana).
2. Iziphumo kunye nohlalutyo
2.1 Isiphumo se-HPMC kwiqondo lokugcina amanzi esimemeni
Ukugcinwa kwamanzi kubhekisa kubuchule bokukhonkotha ukuba babambe amanzi. Kwimo yodaka otshitshisiweyo, ukongeza i-Selessese I-Ether kunokugcina amanzi, kwaye kuncitshiswe izinga lezopha, kwaye kuhlangatyezwane neemfuno ze-hydication epheleleyo. Iziphumo ze-HPMC ekugcinweni kwamanzi.
Ngokwanda kwemixholo ye-HPMC, inqanaba lokugcina amanzi lokutyulwa ngokuthe ngcembe. I-curves ye-hydroxypropyl methylcelcelgalose i-viscosis ene-100, i-150 ne-200 ne-200 ye-pa.s zifana ngokufanayo. Xa umxholo une-0.05% -0.15%, iqondo lokugcina amanzi liyandisa umgca, kwaye xa umxholo yi-0.15%, inqanaba lokugcina amanzi lingaphezulu kwe-93%. ; Xa inani le-grittis lingaphezulu kwe-0.20%, ukwanda kwenqanaba lokugcina amanzi kuya kuba liflethi, kubonisa ukuba isixa se-HPMC sisondele kakhulu ku-satte. I-curve yefuthe le-HPMC nge-viscosity ye-40 passwords yokugcina amanzi iphantse ibe ngumgca othe ngqo. Xa imali inkulu kune-0.15%, inqanaba lokugcina amanzi lodaka liphantsi kakhulu kunezo ezintathu ze-HPMC ngenani elifanayo le-viscofity. Kuyakholelwa ngokubanzi ukuba indlela yokugcina amanzi se-ether selset yile: Iqela le-hydroxyl kwi-selsulose ether molecule ye-thergen ye-elektrone, ukuze amanzi asingenzi, adlale khona umphumo wokugcina amanzi. Kukwakholelwa ukuba i-molekyuli yamanzi kunye neemolekyuli zamanzi i-Ether Moleclor ivumela iimolekyuli zamanzi ukuba zingene kwi-Ethermose ye-Ether i-Eteromolecular kwaye iphucule ukugcinwa kwamanzi kwesamente. Ukugcinwa kwamanzi okugqibeleleyo kunokugcina i-purseneous, kwaye kulula ukuyidibanisa, kwaye ufumane ukusebenza kakuhle, ngelixa kuncitshiswa ukunxiba ngoomatshini kunye nokunyusa ubomi bomatshini wokutshiza.
2.2 Isiphumo se-hydroxypropyl methylcelcelsulose hpmc kwi-Density kunye noMxholo woMoya wokuHlala
Xa isixa se-HPMC siyi-0-0.20%, ukuxinana kodaka kuncipha ngolwandiso lwe-HPMC, ukusuka kwi-2050 kg / m3 ukuya kuthi ga kwiipesenti ezingama-20 ezantsi; Xa inani le-HPMC lingaphezulu kwe-0.20%, ukuxinana kuyancipha. ngokuzolileyo. Ukuthelekisa iindidi zee-4 ze-HPMC ngokundwendwela okwahlukileyo, ukuphakama kwe-viscofity, ukunciphisa uxinzelelo lodaka; I-curves ezixineneyo zesifanisi zinee-viscofis ezixubeneyo ze-150 ne-200 ye-PA. HPMC ngokusisiseko, ebonisa ukuba njengoko i-HPMC iqhubeka ikhula.
Umthetho otshintshwayo womxholo wodaka ungqengqeleka ukhuphiswano lodaka. Xa umxholo we-hydroxypropyl methylcelcelsulose hpmc yi-0-0.20%, ukunyuka komxholo we-HPMC, umxholo wobukhosi wonyuswa ngokusemandleni; Umxholo we-HPMC udlula emva kwe-0.20%, umxholo womoya akafane utshintsha, obonisa ukuba isiphumo sokungena komoya esikrwada kudaka. Iziphumo zokungenela umoya ze-HPMC ngohlobo lwe-150 ne-200 pa.
Iziphumo zokungenela umoya kwi-ether yeselsulose igqitywe ikakhulu yimo yemolekyuli yayo. I-Telupelose Ether inee-hydrophilic zamaqela (i-hydroxyl, i-erte) kunye namaqela e-hydrophobic (i-methyl, umsesane weglucose), kwaye yi-surfacnt. , inomsebenzi womphezulu, ke ngoko ukuba nefuthe lokungena moya. Kwelinye icala, irhasi ye-intshisi inokusebenza njengebhola elukhuni eluphango, ukuphucula ukusebenza kodaka, kuyandisa ivolumu, kwaye kuluncedo kulowo umenzi. Kodwa kwelinye icala, isiphumo sokungenela umoya esonyusa umxholo wodaka kunye nesimo sengqondo emva kokukhulisa, okukhokelela ekunyukeni kweendawo ezinobungozi kwaye zinciphise kakhulu iipropathi zoomatshini. Nangona i-HPMC inefuthe elithile lokungena nomoya, ayinakuthatha indawo yearhente yokungena komoya. Ukongeza, xa i-HPMC kunye nearhente yokungena komoya isetyenziswa ngaxeshanye, iarhente yokungena komoya inokusilela.
2.3 Isiphumo se-HPMC kwiipropathi zoomatshini bokufa kwesamente
Xa isixa se-HPMC siyi-0.05%, amandla afudumeleyo odaka kuncipha kakhulu, kwaye malunga ne-25% ye-25% ye-Hydylcelcel I-HPMCPEL ye-HPMCYLEL ye-HEAME-80%. Xa inani le-HPMC lingaphezulu kwe-0.20%, ukwehla kwamandla e-cheshu kunye namandla ocociweyo lodaka akubonakali. Uhlobo lwe-HPMC alunampembelelo kangako kwiimpawu zodaka zodaka. I-HPMC Yazisa amaqamza amaninzi amancinci, kwaye ifuthe lokungasebenzi komoya kulonge inkalipho yangaphakathi kunye ne-pores enobungozi yodaka, imiphumo yokwehla kwamandla ecinezelayo kunye namandla abo obuguqukayo. Esinye isizathu sokuncipha kodaka kukugcinwa kwamanzi yindlela yokugcina amanzi kwi-Telulose Ether, egcina amanzi esikhundleni esilukhuni, kwaye umlinganiselo omkhulu we-Binder ukhokelela kwimigangatho yebhloko yovavanyo. Ngobuchwephesha bokwakha ngoomatshini, nangona uEther Ether onokwandisa kakhulu inqanaba lokugcina amanzi kunye nokuphucula ukusebenza kwayo, ukuba umthamo mkhulu kakhulu, kuya kubuchaphazela kakhulu iimpawu zodaka, ngoko ke ziya kuba zilinganiswe kakuhle.
Ukonyuka komxholo we-hydroxypropyl methylcelceluplose hpmc, umyinge owongelayo obonisa imeko ekhulayo, eyayinobudlelwane obusisiseko. Oku kungenxa yokuba i-Sele i-Selese eyongeziweyo yazisa inani elikhulu lamaqamza amaninzi, olubangela iziphene ezingaphakathi kudaka Kodwa i-Selese i-Ether Inokuphucula ukuguquguquka kodaka, kuyanceda amandla e-shexise, eyenza iteksi yokwehlisa kancinci. Ngokujonga ngokupheleleyo, isiphumo esidityanisiweyo sesibini sikhokelela kwinyuka komyinge osongelayo.
2.4 Isiphumo se-HPMC kwi-l diemeter yodaka
Ukusuka kwi-curve yobukhulu becala, ubukhulu becala i-Porese yoQhagamshelo kunye neeParamitha ezahlukeneyo zeSahluko, zinokubonwa ukuba i-HPMC inefuthe elikhulu kwimo yesamente
. Kwi-curve yobukhulu becala, indawo yomfanekiso ihamba ngasekunene, kwaye ixabiso le-pore elihambelana nexabiso le-piak iba nkulu. Emva kokongeza i-HPMC, i-Poren Poremeter ye-Poreme yokuthengiswa kwesamente inkulu kakhulu kuneso sesampulu ye-0.3% ye-Posage ye-0.3% ye-Posage yonyuswa nge-2 yesampulu yesampulu.
. Ingabonwa kwiTheyibhile 1 ukuba inani lemingxunya engenabungozi okanye imingxunya enobungozi incitshisiwe emva kokongeza i-HPMC, kwaye inani lemingxunya eliyingozi okanye imingxunya eliyingozi inyuke. Iipores ezingenabungozi okanye iipores eziyingozi zeesampuli ezingaxubekanga ne-HPMC malunga ne-49.4%. Emva kokongeza i-HPMC, ipores engenabungozi okanye iipores eziyingozi zincitshisiwe kakhulu. Ukuthatha idosi ye-0.1% njengomzekelo, iipores ezingenabungozi okanye iipores eziyingozi zincitshiswa malunga ne-45%. %, inani lemingxunya eyoyikisayo inkulu kune-10um inyuke malunga namaxesha ali-9.
. inxulumene nokusasazeka okukhulu. Kodwa kuyo yonke, i-median pore idayimitha, i-pore ye-pore ye-pore ye-pore kunye nomthamo oxutywe yi-HEAMP oxutywe ne-HPMC idla ngokunyuka kwesampulu, ngelixa indawo ethile yomhlaba iyancipha.
IXESHA LOKUQALA: APR-03-2023