Ubushushu be-Thermal gelation ye-cellulose ether HPMC

ukwazisa

I-cellulose ethers zi-anionic water-soluble polymers ezivela kwi-cellulose. Ezi polima zinezicelo ezininzi kumashishini ahlukeneyo anjengokutya, amayeza, izinto zokuthambisa, kunye nolwakhiwo ngenxa yeepropathi zazo ezinjengokuqina, igelling, ukwenza ifilim, kunye nokumilisela. Enye yezona zinto zibalulekileyo ze-cellulose ethers yi-thermal gelation ye-thermal (Tg), iqondo lokushisa apho i-polymer idlula kwinguqu yesigaba ukusuka kwi-sol ukuya kwi-gel. Le propati ibaluleke kakhulu ekumiseleni ukusebenza kwee-ether ze-cellulose kwizicelo ezahlukeneyo. Kweli nqaku, sixoxa ngobushushu be-thermal gelation ye-hydroxypropyl methylcellulose (HPMC), enye yezona zinto zisetyenziswa ngokuqhelekileyo i-cellulose ethers kwishishini.

Ubushushu be-Thermal gelation ye-HPMC

I-HPMC yi-semi-synthetic cellulose ether esetyenziswa ngokubanzi kwizicelo ezahlukeneyo ngenxa yeempawu zayo ezizodwa. I-HPMC inyibilika kakhulu emanzini, yenza izisombululo ezicacileyo ze-viscous kwiindawo eziphantsi. Kwiindawo eziphezulu, i-HPMC yenza iijeli ezibuyiselwa umva xa kufudumeza kunye nokupholisa. I-Thermal gelation ye-HPMC yinkqubo yamanyathelo amabini abandakanya ukubunjwa kwee-micelles ezilandelwa ukuhlanganiswa kwee-micelles ukwenza inethiwekhi ye-gel (Umfanekiso 1).

Ubushushu be-thermal gelation ye-HPMC ixhomekeke kwizinto ezininzi ezifana ne-degree of substitution (DS), ubunzima be-molecular, i-concentration, kunye ne-pH yesisombululo. Ngokubanzi, ukuphakama kwe-DS kunye nobunzima bemolekyuli ye-HPMC, buphezulu ubushushu be-thermal gelation. Ukuxinwa kwe-HPMC kwisisombululo kwakhona kuchaphazela i-Tg, i-concentration ephezulu, i-Tg ephezulu. I-pH yesisombululo nayo ichaphazela i-Tg, kunye nezisombululo ze-acidic ezibangelwa i-Tg ephantsi.

I-Thermal gelation ye-HPMC ibuyiselwa umva kwaye inokuchatshazelwa zizinto ezahlukeneyo zangaphandle ezifana ne-shear force, ubushushu, kunye noxinzelelo lwetyuwa. I-Shear iphula isakhiwo se-gel kwaye iyancipha i-Tg, ngelixa ukwanda kweqondo lokushisa kubangela ukuba i-gel inyibilike kwaye iyancipha i-Tg. Ukongeza ityuwa kwisisombululo kuchaphazela i-Tg, kwaye ubukho bee-cations ezifana ne-calcium kunye ne-magnesium kwandisa i-Tg.

Ukusetyenziswa kwe-Tg HPMC eyahlukileyo

Ukuziphatha kwe-thermogelling ye-HPMC inokulungiswa kwizicelo ezahlukeneyo. I-Tg ephantsi ye-HPMCs isetyenziswa kwizicelo ezifuna i-gelation ekhawulezayo, njenge-dessert ekhawulezileyo, i-sauce kunye ne-soup formulations. I-HPMC ene-Tg ephezulu isetyenziswa kwizicelo ezifuna ukulibaziseka okanye i-gelation ixesha elide, njengokuqulunqwa kweenkqubo zokuhanjiswa kweziyobisi, iipilisi zokukhululwa okuqhubekayo, kunye nokubopha amanxeba.

Kwishishini lokutya, i-HPMC isetyenziswa njenge-thickener, i-stabilizer kunye ne-agent ye-gelling. I-Tg ephantsi ye-HPMC isetyenziselwa ukwakhiwa kwedizethi ekhawulezileyo efuna i-gelation ekhawulezayo ukubonelela ukuthungwa okufunwayo kunye ne-mouthfeel. I-HPMC ene-Tg ephezulu isetyenziselwa ukwakheka kwamafutha aphantsi apho kulibaziseka okanye ixesha elide i-gelation ifunwa ukukhusela i-syneresis kunye nokugcina isakhiwo sokusasazeka.

Kwishishini lamayeza, i-HPMC isetyenziswa njenge-binder, i-disintegrant kunye ne-arhente yokukhululwa eqhubekayo. I-HPMC ene-Tg ephezulu isetyenziswa ekuqulunqweni kwamacwecwe okukhululwa okwandisiweyo, apho ukulibaziseka okanye i-gelation ixesha elide kufuneka ukukhulula iyeza kwixesha elide. I-Tg ephantsi ye-HPMC isetyenziswe ekuqulunqweni kwamacwecwe okutshatyalaliswa ngomlomo, apho ukuchithwa ngokukhawuleza kunye ne-gelation kuyadingeka ukubonelela ngomlomo ofunwayo kunye nokulula ukugwinya.

ukuququmbela

Ubushushu be-thermal gelation ye-HPMC yipropati ephambili emisela ukuziphatha kwayo kwizicelo ezahlukeneyo. I-HPMC inokulungelelanisa i-Tg yayo ngeqondo lokutshintshwa, ubunzima bemolekyuli, ugxininiso kunye nexabiso le-pH yesisombululo ukuze ihambelane nezicelo ezahlukeneyo. I-HPMC ene-Tg ephantsi isetyenziselwa izicelo ezifuna i-gelation ekhawulezayo, ngelixa i-HPMC ene-Tg ephezulu isetyenziselwa izicelo ezifuna ukulibaziseka okanye ukuchithwa kwexesha elide. I-HPMC yi-ether yeselulosi eguquguqukayo enemisebenzi emininzi enokwenzeka kumashishini ahlukeneyo.