IHypromellose, ekwaziwa ngokuba yi-hydroxypropyl methylcellulose (HPMC), yipolymer esebenza ngeendlela ezininzi ephuma kwi-cellulose. Ngenxa yeempawu zayo ezizodwa zeekhemikhali kunye nezomzimba, i-HPMC isetyenziswa ngokuqhelekileyo njenge-thickener, i-stabilizer kunye ne-adhesive kwi-pharmaceutical, ukutya kunye nokunyamekela komntu. Kweli nqaku, sixoxa ngekhemikhali ye-HPMCs kunye nezicelo zabo ezibalulekileyo.
1. Ukunyibilika
Enye yezona zinto zibalulekileyo zemichiza ye-HPMC kukunyibilika kwayo. I-HPMC iyanyibilika emanzini kunye nezinyibilikisi ezininzi eziphilayo, iyenza ibe licandelo elifanelekileyo leenkqubo zokuhanjiswa kweziyobisi kunye nezinye izicelo ezifuna ukuchithwa. Nangona kunjalo, ukunyibilika kwe-HPMC kumiselwa ubukhulu becala liqondo layo lokuthatha indawo (DS), elimisela inani le-hydroxypropyl kunye namaqela e-methyl akhoyo kwikhonkco le-polymer. Ii-HPMC ezine-DS eziphezulu zine-solubility ephantsi ngenxa yokunyuka kwentsebenziswano ye-intermolecular.
2. Rheology
Enye ipropati ebalulekileyo yemichiza ye-HPMC yindlela yokuziphatha kwayo. Isakhono se-HPMC sokwenza uthungelwano olufana nejeli phezu kokugalelwa kwamanzi kungasetyenziselwa ukulawula i-viscosity kunye neempawu zokuqukuqela zemixube. I-HPMC ikwabonisa ukuziphatha kokuqukuqela okungeyokwa-Newtonian, okuthetha ukuba i-viscosity yayo iyatshintsha ngokwezinga lokucheba elisetyenzisiweyo. Le propati inokulawulwa ngakumbi ngokulungelelanisa i-concentration ye-HPMC kunye ne-DS ekuqulunqweni.
3. Ukuqulunqwa kwefilimu
I-HPMC ikwasetyenziswa ngokubanzi njengefilimu yangaphambili ngenxa yokukwazi ukwenza iifilimu ezifanayo xa isetyenziswa kwi-substrate. Iimpawu zokwenza ifilimu ye-HPMC zixhomekeke kwi-DS yayo, i-viscosity kunye nobukho be-plasticizers, enokuphucula i-elasticity kunye nokuguquguquka kwefilimu. Iifilim ezenziwe kwi-HPMC ziqhele ukusetyenziswa kunikezelo lweziyobisi kuba zivumela ukukhutshwa okulawulwayo kwezithako ezisebenzayo.
4. Ukuhambelana
I-HPMC yi-excipient ehambelana kakhulu kwaye ingasetyenziswa kwiintlobo ezahlukeneyo zemixube. Iyahambelana nezithako ezininzi zamachiza, kubandakanywa izithako ezisebenzayo zamachiza (APIs) kunye nezinye izinto ezincedisayo ezisetyenziswa ngokuqhelekileyo ekuqulunqweni kwamachiza. I-HPMC ikwahambelana nezithako ezininzi zokutya, iyenza ibe lukhetho oludumileyo kwizicelo zokutya.
5. Ukuzinza kweekhemikhali
I-HPMC yipolymer ezinzileyo exhathisa i-hydrolysis kunye nezinye iimpendulo zemichiza. Olu uzinzo luyenza ibe sisithako esifanelekileyo kwiinkqubo zokuhanjiswa kweziyobisi njengoko ikhusela isithako esisebenzayo ekuthotyweni kwaye inyusa i-bioavailability yayo. Nangona kunjalo, ukuzinza kweekhemikhali ze-HPMC kunokuchaphazeleka kubushushu obuphezulu, ukufuma okuphezulu, kunye nezinyibilikisi ezithile, ezinokubangela ukuba i-polymer ithobe kwaye inciphise ukusebenza kwayo ekuqulunqweni.
6. Biocompatibility
Okokugqibela, i-HPMC yipolymer ehambelana kakhulu ne-biocompatible ekhuselekileyo ekusebenziseni amayeza kunye neemveliso zokhathalelo lomntu. Ayinatyhefu, ayinayo i-immunogenic kunye ne-biodegradable, iyenza ilungele ukwakheka okudinga ubutyhefu obuncinci kunye nokhuseleko oluphezulu.
Isishwankathelo, i-HPMC hypromellose i-polymer esebenzayo kunye noluhlu lwezinto ezibalulekileyo zekhemikhali, kubandakanywa ukunyibilika, i-rheology, iipropati zokwenza ifilimu, ukuhambelana, ukuzinza kweekhemikhali, kunye ne-biocompatibility. Ezi propati zenza ukuba kube ngumxhasi ofanelekileyo kwiinkqubo zokuhanjiswa kweziyobisi kunye nezinye izicelo kumashishini okutya kunye nokhathalelo lomntu. Njengoko uphando luqhubeka nokwandisa ukuqonda kwethu ii-HPMCs, iipropathi zazo ezizodwa zinokufumana usetyenziso olubanzi kwixesha elizayo.
Ixesha lokuposa: Jul-28-2023