Yintoni i-HPMC kumzi-mveliso wamachiza?

I-HydroxypropyTolmethylcelcelcelcelcelcebalose Yenzelwe udidi lwe-elsulose ye-elselose kwaye lufumaneka kwiseli yendalo. I-HPMC idityanisiwe ngokunyanga isellulose kunye ne-propylene oxide kunye ne-methyl chloride, ikhokelela kwimilinganiselo yokuqina okuphuculweyo kunye nezinye iimpawu ezinqwenelekayo. Lo mbono wamayeza usetyenziswa ngokubanzi kuphuhliso kunye nemveliso yeefom ze-dosis ezahlukeneyo, kubandakanya iitafile, ii-capsules, i-ophthalmic kunye nokulawulwa kwenkqubo yokuhambisa iziyobisi.

Intshayelelo kwiHydroxypropyl Methylcelcelose:

Isakhiwo sekhemikhali kunye neepropathi:

I-Hydroxypropyl Methylcelcelcelose i-semi-synthetic, i-init, i-polymer enyibilikayo yamanzi. Inkqubo yayo yemichiza ibandakanya i-hydroxypropy kunye namaqela e-AFDISS eqhotyoshelwe kwi-Selebose Talbone. Inxalenye yezi zinto zithathekileyo zinokwahluka, zikhokelela kumabakala ahlukeneyo e-HPMC enepropathi eyahlukeneyo. Ipateni yokungena endaweni ichaphazela iiparamitha ezinjenge-viscofity, isoba, kunye neepropathi zejeli.

Inkqubo yeMveliso:

Ukuveliswa kwe-HPMC kubandakanya isiko le-seluplose nge-propylene oxide kunye ne methyl chloride. Inqanaba lokufakwa endaweni (DS) ye-hydroxypropy kunye namaqela e-AFGISY inokulawulwa ngexesha leSynthesi, ivumela ukulungelelaniswa kwepropathi ye-HPMC kwiimfuno ezithile zokuqulunqwa kweziyobisi.

Izicelo kumzi-mveliso wamachiza:

I-Binders kwiFowuni yeTafile:

I-HPMC isetyenziswa ngokubanzi njenge-binder kwifom yetafile. Ipropathi yayo yokubopha inqaku lokucinezela umgubo kwiitafile eziqinileyo. Ukukhutshwa okulawulwa kwezithako ezisebenzayo (i-APIS) zinokufezekiswa ngokusebenzisa amabanga athile e-HPMC ngohlobo olufanelekileyo kunye namanqanaba afanelekileyo.

Iarhente yefilimu

I-HPMC isetyenziswa njenge-arhente yefilimu yeetafile kunye neegram. Inika indawo yokukhusela efanayo eyonwabisayo ephucula imbonakalo, ukungcamla imaski kunye nokuzinza kweefom ze-dosage. Ngaphaya koko, iingubo ze-HPMC zinokuvuma iiprofayili zokukhupha iziyobisi.

Ukukhutshwa okuzinzileyo nolawulwa:

Uhlobo lwe-hydrophilic yale polymer yenza ukuba ilungele ukusetyenziswa kwifomu eqinisekisiweyo- kwaye ilawulwa. Imatrix ye-HPMC ivumela ukukhutshwa kweziyobisi ezilawulwayo ixesha elide, ukuphucula ukuthotyelwa koguli kunye nokunciphisa ireyithi yedosi.

Amalungiselelo e-Ophthalmic:

Kwifomu ye-OphThalmic, i-HPMC isetyenziselwa ukwandisa i-viscosity yehla, ngaloo ndlela ibonelela ngexesha elide lokuhlala kumphezulu we-ocular. Oku kuphucula i-biaaaaaaaaaint yeziyobisi kunye nokusebenza ngonyango.

I-stickeng stiblizer:

I-HPMC isetyenziswa njenge-thi checkener kunye ne-stabilizer kwifomu engamanzi kunye ne-semi-eqinileyo enjengeeglasi, iikhrim kunye nokumiswa. Inika i-victosity kule fomulas kwaye iphucule iipropathi zawo zeRheeology.

Iimpawu eziphambili ze-HPMC:

Umoya wobuchule:

I-HPMC inyibilikisa emanzini kwaye icacisa isisombululo esicacileyo, esingenamibala. Ireyithi yokupheliswa ichatshazelwe linqanaba lokufaka endaweni kunye nebakala lokubonisa.

I-Viskosity:

UVenkile weZisombululo ze-HPMC ubaluleke kakhulu ekumiseleni ukusebenza kwabo kwizicelo ezahlukeneyo. Amabakala ahlukeneyo ayafumaneka ngeendlela ezahlukeneyo zokundwendwela, evumela ulawulo olufanelekileyo lweepropathi ze-RIOOOOOORTTER YOKUGQIBELA.

I-Termal:

Amabakala athile o-HPMC abonisa iipropathi ze-thermogel, akha iigesi kumaqondo obushushu aphezulu. Le ndawo isetyenziselwa ukukhulisa iifomu ezibuthathaka zobushushu.

Ukuhambelana:

I-HPMC iyahambelana noluhlu olubanzi lwee-wandericeuticals kunye ne-APIS, zenza ukhetho lokuqala lweefomu. Ayisabi senzelwanga okanye ihlazo izithako ezisebenzayo.

Imiceli mngeni kunye nokuqwalaselwa:

I-hygroscopicity:

I-HPMC i-hygroscopic, oko kuthetha ukuba ifumana umswakama kwindalo esingqongileyo. Oku kuchaphazela uzinzo nembonakalo yokuqulunqwa, ngoko ke kuyafuneka iimeko zokugcina ngokufanelekileyo.

Ukuhambelana nezinye iziqulatho:

Nangona ihambelana ngokubanzi, kufuneka iqwalasele ukungqinelana kwe-HPMC nabanye abanomdla kuthintela ukusebenzisana okunokubakho okuchaphazela intsebenzo yokuqulunqwa.

Impembelelo kwi-curve yokugqabhoka:

Ukhetho lwebanga le-HPMC lunokuchaphazela kakhulu ukutshabalalisa iprofayili yechiza. Ifomula kufuneka inyule ngononophelo kwinqanaba elifanelekileyo lokufezekisa iimpawu zokukhutshwa okufunekayo.

Ukuqwalaselwa kolawulo:

I-HPMC yamkelwe ngokubanzi njengokukhuseleka okukhuselekileyo nenempumelelo. Idibana nemigangatho eyahlukeneyo yomthetho kwaye ifakiwe kwi-pharmacopoeiaiaiaiaias kwihlabathi liphela. Abavelisi bafanele bathobele iinkqubo zokwenza imveliso (i-GMP) ukuqinisekisa umgangatho kunye nokungaguquguquki kweemveliso zamayeza ezineemveliso ze-HPMC.

ukuququmbela:

I-HydroxypropylMethylcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelce Iipropathi zayo ezizodwa zenza ukuba zilungele ukusetyenziswa kwiifom ze-dosage ezahlukeneyo, kubandakanya iitafile, iicapbules kunye namalungiselelo e-ophthalmic. Iifomulareys zixhamla ekwenzeni ukulungisa iipropathi ze-HPMC zokuhlangabezana neemfuno zokuqulunqwa, ezinje ngokukhululwa okulawulwayo kunye nokuphuculwa kokuzinza. Ngaphandle kwemiceli mngeni, i-HPMC ihlala isithako esiphambili kuphuhliso lweemveliso ezikumgangatho ophezulu zamayeza, zinegalelo kukhuseleko kunye nokusebenza ngokufezekiswa kwamachiza amaninzi.