Yenziwe ngantoni ihydroxypropyl methylcellulose?

IHydroxypropyl methylcellulose (HPMC) yipolymer eguquguqukayo kwaye isetyenziswa ngokubanzi kumashishini ahlukeneyo, eyaziwa ngeempawu zayo ezizodwa kunye nokusetyenziswa kwayo. Le khompawundi iphuma kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zezityalo. Ukuqonda ukubunjwa kwe-hydroxypropylmethylcellulose, kuyimfuneko ukukhangela kwisakhiwo kunye nokudibanisa le mveliso ye-cellulose.

Ubume be-cellulose:

I-Cellulose i-carbohydrate eyinkimbinkimbi equkethe i-chain chain ye-β-D-glucose units ezidityaniswe yi-β-1,4-glycosidic bonds. La matyathanga eglucose abanjwe kunye ngamabhondi e-hydrogen ukuze enze ulwakhiwo oluluqilima lomgca. I-Cellulose iyona nxalenye yesakhiwo seendonga zeeseli zesityalo, inika amandla kunye nokuqina kwiiseli zezityalo.

Izinto eziphuma kwiHydroxypropyl methylcellulose:

IHydroxypropyl methylcellulose idityaniswe ngokuguqula iikhemikhali zeselulosi kunye nokwazisa amaqela e-hydroxypropyl kunye ne-methyl kwikhonkco eliphambili leselulosi. Imveliso idla ngokubandakanya la manyathelo alandelayo:

Impendulo ye-Etherification:

I-Methylation: Ukunyanga i-cellulose ngesisombululo se-alkaline kunye ne-methyl chloride ukwazisa amaqela e-methyl (-CH3) kumaqela e-hydroxyl (-OH) ye-cellulose.

I-Hydroxypropylation: I-cellulose ye-methylated iphinda iphendule nge-propylene oxide ukwazisa amaqela e-hydroxypropyl (-CH2CHOHCH3) kwisakhiwo se-cellulose. Le nkqubo iphucula ukunyibilika kwamanzi kunye nokutshintsha izinto ezibonakalayo zeselulosi.

ukuhlanjululwa:

I-cellulose elungisiweyo ihlanjululwe ke ukuze isuse naziphi na ii-reagents ezingaphendulwanga, iimveliso eziphumayo okanye ukungcola.

Ukomisa nokusila:

I-hydroxypropyl methylcellulose ecocekileyo yomile kwaye igalelwe ibe ngumgubo ococekileyo olungele ukusetyenziswa kwizicelo ezahlukeneyo.

Izithako zeHydroxypropyl Methylcellulose:

Ukuqulunqwa kwe-hydroxypropyl methylcellulose kubonakaliswa yinqanaba lokutshintshwa, elibhekiselele kwiqondo apho i-hydroxypropyl kunye namaqela e-methyl athatha indawo yamaqela e-hydroxyl kwikhonkco leselulosi. Amabanga ahlukeneyo e-HPMC anemigangatho eyahlukeneyo yokutshintsha, echaphazela ukunyibilika kwawo, i-viscosity kunye nezinye iipropathi.

I-formula yekhemikhali ye-hydroxypropyl methylcellulose ingabonakaliswa njenge (C6H7O2 (OH) 3-mn (OCH3) m (OCH2CH (OH) CH3) n) _x, apho i-m kunye ne-n imele iqondo lokutshintshwa.

m: iqondo le-methylation (amaqela e-methyl ngokweyunithi yeglucose)

n: iqondo le-hydroxypropylation (amaqela e-hydroxypropyl kwiyunithi yeglucose nganye)

x: inani leeyunithi zeglucose kwikhonkco leselulosi

Iimpawu kunye nezicelo:

Ukunyibilika: I-HPMC inyibilika emanzini, kwaye inqanaba lokutshintsha lichaphazela iimpawu zayo zokunyibilika. Yenza isisombululo esicacileyo kunye ne-viscous emanzini, okwenza kube yinto efanelekileyo kwiintlobo ezahlukeneyo zokuqulunqa.

I-Viscosity: I-viscosity yesisombululo se-HPMC ixhomekeke kwizinto ezifana nobunzima be-molecular kunye neqondo lokuthatha indawo. Le propati ibaluleke kakhulu kwizicelo ezifana namayeza afuna imixube elawulwayo yokukhululwa.

Ukwenziwa kweFilimu: I-HPMC inokwenza iifilimu ezibhityileyo njengoko isisombululo somile, sisenza ukuba luncedo ekugqumeni kumayeza, ukutya nakwamanye amashishini.

Izinzisi kunye neeThickeners: Kushishino lokutya, i-HPMC isetyenziswa njenge-thickener kunye ne-stabilizer kwiimveliso ezahlukeneyo, kubandakanywa iisosi, izimuncumuncu, kunye neempahla ezibhakiweyo.

Izicelo zeMichiza: I-HPMC isetyenziswa ngokubanzi kwimiqulu yeyeza, kubandakanywa iipilisi, iipilisi, kunye nezisombululo zamehlo, ngenxa yokulawulwa kwayo kokukhululwa kunye nokuhambelana kwezinto eziphilayo.

Ulwakhiwo kunye nokwaleka: I-HPMC isetyenziswa kwizinto zokwakha ezifana nodaka, izinto zokuncamathelisa iithayile kunye neeplasta. Ikwasetyenziswa njenge-thickener kunye ne-stabilizer kwipeyinti kunye ne-coating formulations.

IiMveliso zoNonophelo loBuqu: Kwizimonyo kunye neshishini lokhathalelo lomntu, i-HPMC ifumaneka kwiimveliso ezinjengeekhrimu, ii-lotions kunye neshampoos, apho ibonelela ngokuthungwa kunye nokuzinza.

I-Hydroxypropyl methylcellulose ifumaneka nge-methylation kunye ne-hydroxypropylation ye-cellulose. Yipolymer eneenjongo ezininzi ezinoluhlu olubanzi losetyenziso. Iimpawu zayo ezizodwa zenza ukuba zixabiseke kumashishini afana namayeza, ukutya, ukwakhiwa kunye nokunyamekela komntu. Uhlengahlengiso olulawulwayo lweselulosi lunokulungisa iipropathi ze-HPMC, iyenze ibe yinxalenye ebalulekileyo yeemveliso ezininzi esidibana nazo kubomi bethu bemihla ngemihla.