I-HPMC (i-hydroxypropyl methylcellulose) yi-ether ye-cellulose engekho ionic esetyenziswa ngokubanzi kulwakhiwo, amayeza, ukutya, imichiza yemihla ngemihla kunye namanye amashishini. Ngokwendlela yokupheliswa kwayo kunye neempawu zesicelo, i-HPMC inokwahlulwa ibe ziindidi ezimbini: uhlobo olukhawulezileyo kunye nohlobo lokunyibilika okushushu. Kukho iiyantlukwano ezibalulekileyo phakathi kwezi zimbini ngokwenkqubo yemveliso, iimeko zokuchithwa kunye neemeko zesicelo.
1. I-HPMC ekhawulezileyo
I-HPMC ekhawulezileyo, ekwabizwa ngokuba luhlobo olunyibilikayo lwamanzi abandayo, inokunyibilika ngokukhawuleza emanzini abandayo ukwenza isisombululo se-colloidal esobala. Iimpawu zayo eziphambili zezi zilandelayo:
1.1. Ukunyibilika
I-HPMC ekhawulezileyo ibonisa ukunyibilika okugqwesileyo kumanzi abandayo kwaye isasazwe ngokukhawuleza xa ibhengezwe emanzini. Iyakwazi ukuchithwa ngexesha elifutshane ukwenza isisombululo esifanayo, ngokuqhelekileyo ngaphandle kwesidingo sokufudumeza. Isisombululo saso samanzi sinokucaca kakuhle, ukuzinza kunye nokulungiswa kwe-viscosity.
1.2. Iimeko zesicelo
I-HPMC ekhawulezileyo isetyenziswa ikakhulu kwiimeko ezifuna ukupheliswa ngokukhawuleza kunye nokwenziwa kwesisombululo. Iindawo ezisetyenziswayo eziqhelekileyo ziquka:
Indawo yokwakha: isetyenziswa njengearhente yokugcina amanzi kunye ne-ejenti yokuqina kwizinto ezisekwe kwisamente kunye neemveliso zegypsum ukunceda ukuphucula ukusebenza kolwakhiwo.
Iimveliso zemichiza yemihla ngemihla: njengezokucoca, iishampu, izithambiso, njl.njl., i-HPMC ekhawulezileyo inokubonelela ngeziphumo ezityebileyo kunye nokunqunyanyiswa kweemveliso, kwaye inyibilika ngokukhawuleza, iyenze ilungele iimeko zokulungiselela ngokukhawuleza.
Imboni yamachiza: Isetyenziswe njenge-agent-forming agent, i-adhesive, njl. Inokuchithwa ngokukhawuleza emanzini abandayo ukuququzelela ukuveliswa kwamalungiselelo.
1.3. Iingenelo
Ichithwa ngokukhawuleza kwaye ifanelekile kwiimeko zokucubungula okubandayo.
Kulula ukuyisebenzisa kunye noluhlu olubanzi lokusebenzisa.
Isisombululo sinokucaca okuphezulu kunye nokuzinza okulungileyo.
2. Hot zinyibilike HPMC
I-HPMC enyibilikayo eshushu, ekwabizwa ngokuba luhlobo olunyibilikayo lwamanzi ashushu okanye uhlobo lonyibiliko lokulibaziseka, kufuneka ichithwe ngokupheleleyo emanzini ashushu, okanye inokufuna ixesha elide lokunyibilika emanzini abandayo ukwenza isisombululo ngokuthe ngcembe. Iimpawu zayo zezi zilandelayo:
2.1. Ukunyibilika
Ukuziphatha kokupheliswa kwe-HPMC enyibilikayo eshushu yahluke kakhulu kuleyo yohlobo lwangoko. Kumanzi abandayo, i-HPMC eshushu-enyibilikayo iyachithachitha kuphela kodwa ayinyibiliki. Iya kunyibilika kuphela kwaye yenze isisombululo xa ishushu kwiqondo elithile lobushushu (ngokuqhelekileyo malunga ne-60 ° C). Ukuba yongezwa kumanzi abandayo kwaye ivuselelwe ngokuqhubekayo, i-HPMC iya kutsala amanzi ngokuthe ngcembe kwaye iqalise ukunyibilika, kodwa inkqubo ihamba kancinci.
2.2. Iimeko zesicelo
I-Hot-melt HPMC isetyenziswa ikakhulu kwiimeko apho ixesha lokuchithwa okanye iimeko ezithile zokulungiswa kwe-thermal kufuneka zilawulwe. Iindawo ezisetyenziswayo eziqhelekileyo ziquka:
Izinto zokwakha: ezifana ne-adhesives yokwakha, udaka lokutyabeka, njl., i-HPMC eshushu-enyibilikayo inokulibazisa ukutshatyalaliswa, ukunciphisa i-agglomeration ngexesha lokuxuba okanye ukuvuselela, kunye nokuphucula umsebenzi wokwakha.
Umzi-mveliso wamachiza: Njengezinto zokugquma iipilisi ezikhutshwa ngokuzinzileyo, njl. njl., i-HPMC enyibilikayo eshushu inceda ukulawula izinga lokukhutshwa kwamachiza ngonyibiliko lwawo kumaqondo obushushu ahlukeneyo.
Umzi-mveliso wokugquma: usetyenziselwa ukugquma izicelo phantsi kweemeko ezithile ezikhethekileyo zobushushu obuphezulu ukuqinisekisa ukubunjwa kwefilimu okugqwesileyo kunye nokuzinza ngexesha lenkqubo yokwakha.
2.3. Iingenelo
Inokulibazisa ukupheliswa kwaye ifanelekile kwizihlandlo ezineemfuno ezizodwa kwisantya sokuchithwa.
Ikhusela i-agglomeration emanzini abandayo kwaye inokusebenza kakuhle kokusasazwa.
Ifanelekile ukuqhutyelwa kwe-thermal okanye izicelo apho ukulawulwa kwenkqubo yokuchithwa kuyadingeka.
3. Umahluko ophambili phakathi kohlobo olukhawulezileyo kunye nohlobo olunyibilikayo olushushu
3.1. Iindlela ezahlukeneyo zokuphelisa
I-HPMC ekhawulezileyo: Inokunyibilika ngokukhawuleza emanzini abandayo ukwenza isisombululo esicacileyo, esilula kwaye sisebenzise ngokukhawuleza.
I-Hot-melt HPMC: Kufuneka inyibilikiswe emanzini ashushu okanye idinga ukunyibilika ngokupheleleyo emanzini abandayo ixesha elide, elilungele iimfuno ezithile zolawulo lokupheliswa.
3.2. Umahluko kwimimandla yesicelo
Ngenxa yeempawu zayo zokuchithwa ngokukhawuleza, i-HPMC esheshayo ifanelekile kwiimeko apho isisombululo kufuneka senziwe ngokukhawuleza, njengokwakhiwa kunye nokulungiswa kwemveliso yemichiza yemihla ngemihla. I-Hot-melt HPMC isetyenziswa kakhulu kwiimeko apho ukulibaziseka kokupheliswa kuyadingeka, ngakumbi kwiindawo zokwakha ezinobushushu obuphezulu okanye iindawo ezineemfuno ezingqongqo zexesha lokuchithwa.
3.3. Umahluko kwinkqubo yemveliso
Ngexesha lenkqubo yemveliso, i-HPMC ekhawulezileyo iguqulwa ngokwekhemikhali ukuba inyibilike ngokukhawuleza emanzini abandayo. I-Hot-melt HPMC igcina iimpawu zayo zokuqala kwaye kufuneka zinyibilike emanzini ashushu. Ke ngoko, kwizicelo zokwenyani zemveliso, kuyafuneka ukuba ukhethe uhlobo olufanelekileyo lweHPMC ngokwemiqathango yenkqubo eyahlukeneyo kunye neemfuno zemveliso.
4. Izinto ekufuneka uziqwalasele xa ukhetha HPMC
Xa ukhetha ukusebenzisa i-HPMC enyibilikayo ngoko nangoko okanye eshushu, kufuneka wenze isigwebo esisekwe kwiimfuno ezithile zesicelo:
Kwiimeko ezifuna ukuchithwa ngokukhawuleza: ezifana nezixhobo zokwakha ezifunekayo ukuba zisetyenziswe ngokukhawuleza ngexesha lemveliso, okanye iimveliso zemichiza yemihla ngemihla ezilungiswe ngokukhawuleza, i-HPMC yokuchithwa ngokukhawuleza kufuneka ikhethwe.
Kwiimeko ezifuna ukulibaziseka kokupheliswa okanye ukuqhutyelwa kwe-thermal: ezifana ne-mortars, i-coatings, okanye i-tablet yokukhululwa kweziyobisi ezifunekayo ukulawula izinga lokuchithwa ngexesha lokwakhiwa, i-HPMC eshushu-enyibilikayo kufuneka ikhethwe.
Kukho iiyantlukwano ezicacileyo ekusebenzeni kokupheliswa kunye nemimandla yesicelo phakathi kwe-HPMC ekhawulezileyo kunye ne-hot-melt HPMC. Uhlobo olukhawulezayo lufanelekile kwizicelo ezifuna ukuchithwa ngokukhawuleza, ngelixa uhlobo olushushu lwe-melt lufanelekile ngakumbi kwiimeko ezifuna ukulibaziseka ukuchithwa okanye ukuqhutyelwa kwe-thermal. Kwizicelo ezithile, ukukhetha uhlobo olufanelekileyo lweHPMC kunokuphucula ukusebenza kakuhle kwemveliso kunye nokwandisa ukusebenza kwemveliso. Ngoko ke, kwimveliso yokwenene kunye nokusetyenziswa, kuyimfuneko ukukhetha ngokufanelekileyo uhlobo lwe-HPMC ngokusekelwe kwiimeko ezithile zenkqubo kunye neemfuno zemveliso.
Ixesha lokuposa: Sep-25-2024