Lithini ixabiso le-pH le-hydroxyethyl cellulose

I-Hydroxyethyl cellulose (HEC) i-non-ionic, i-polymer e-soluble yamanzi ephuma kwi-cellulose, i-polymer eyenzeka ngokwemvelo efumaneka kwiindonga zeeseli zezityalo. Isetyenziswa kakhulu kumashishini ahlukeneyo afana namayeza, izinto zokuthambisa, iipeyinti, izinto zokuncamathelisa, kunye neemveliso zokutya ngenxa yeempawu zayo ezizodwa ezinjengokuqina, ukuzinzisa, kunye nokugcina amanzi. Nangona kunjalo, ukuxoxa ngexabiso le-pH ye-HEC kufuna ukuqonda okubanzi kweempawu zayo, ulwakhiwo, kunye nokusetyenziswa kwayo.

Ukuqonda i-Hydroxyethyl Cellulose (HEC):

1. Ulwakhiwo lweMichiza:

I-HEC yenziwe ngokuphendula kwe-cellulose nge-ethylene oxide, okubangelwa ukuqaliswa kwamaqela e-hydroxyethyl (-CH2CH2OH) kwi-backbone ye-cellulose.

Iqondo lokuthatha indawo (DS) libhekisa kwiavareji yenani lamaqela e-hydroxyethyl ngeyunithi yeglucose kwikhonkco leselulosi kwaye imisela iipropati ze-HEC. Amaxabiso aphezulu e-DS akhokelela ekwandeni kokunyibilika kwamanzi kunye ne-viscosity ephantsi.

2. Iinkcazelo ngeempawu:

I-HEC iyanyibilika emanzini kwaye yenza izisombululo ezicacileyo, ezenza ukuba zilungele izicelo ezahlukeneyo ezifuna ukwakheka okucacileyo.

Ibonisa ukuziphatha kwe-pseudoplastic, oku kuthetha ukuba i-viscosity yayo iyancipha phantsi koxinzelelo lwe-shear, ivumela ukusetyenziswa okulula kunye nokuphathwa.

I-viscosity yezisombululo ze-HEC iphenjelelwa yizinto ezifana nokugxininiswa, ukushisa, i-pH, kunye nobukho beetyuwa okanye ezinye izongezo.

3. Usetyenziso:

Amachiza: I-HEC isetyenziswa njenge-thickener kunye ne-stabilizer kwi-oral and topical pharmaceutical formulations ezifana ne-ointments, i-creams, kunye nokumiswa.

Izithambiso: Sisithako esixhaphakileyo kwiimveliso zokhathalelo lomntu siqu eziquka ishampu, izinto zokuthambisa, kunye neekhrimu ngenxa yokujiya kunye neempawu zokuthambisa.

Iipende kunye neeNgxoxo: I-HEC yongezwa kwiipende, iingubo, kunye ne-adhesives ukulawula i-viscosity, ukuphucula iimpawu zokuhamba, kunye nokuphucula ukubunjwa kwefilimu.

Ishishini lokutya: Kwiimveliso zokutya, i-HEC isebenza njenge-thickener, stabilizer, kunye ne-emulsifier kwizinto ezifana neesosi, iilokhwe, kunye neemveliso zobisi.

pH Ixabiso le-Hydroxyethyl Cellulose (HEC):

1. Ukuxhomekeka kwe-pH:

I-pH yesisombululo esiqulethe i-HEC inokuchaphazela ukuziphatha kwayo kunye nokusebenza kwayo kwizicelo ezahlukeneyo.

Ngokuqhelekileyo, i-HEC izinzile kuluhlu olubanzi lwe-pH, ngokuqhelekileyo phakathi kwe-pH 2 kunye ne-pH 12. Nangona kunjalo, iimeko ezigqithisileyo ze-pH zinokuchaphazela iimpawu zayo kunye nokuzinza.

2. Iimpembelelo ze-pH kwi-Viscosity:

I-viscosity yezisombululo ze-HEC inokuxhomekeka kwi-pH, ngokukodwa kwixabiso eliphezulu okanye eliphantsi le-pH.

Kufuphi noluhlu lwe-pH olungathathi hlangothi (pH 5-8), izisombululo ze-HEC zihlala zibonisa i-viscosity yazo ephezulu.

Kwixabiso eliphantsi kakhulu okanye eliphezulu le-pH, i-backbone ye-cellulose inokuthi iqhube i-hydrolysis, okubangelwa ukuhla kwe-viscosity kunye nokuzinza.

3. Uhlengahlengiso lwe-pH:

Kwimixube apho uhlengahlengiso lwe-pH luyimfuneko, izithinteli zihlala zisetyenziselwa ukugcina uluhlu lwe-pH olufunekayo.

Izithinteli eziqhelekileyo ezifana ne-citrate okanye i-phosphate buffers ziyahambelana ne-HEC kwaye zinceda ukuzinzisa iimpawu zayo ngaphakathi koluhlu oluthile lwe-pH.

4. Iingqwalasela zeSicelo:

Abaqulunqi kufuneka baqwalasele ukuhambelana kwe-pH ye-HEC kunye nezinye izithako ekuqulunqweni.

Kwezinye iimeko, uhlengahlengiso kwi-pH yokuqulunqwa kunokufuneka ukuba kulungiswe ukusebenza kwe-HEC.

IHydroxyethyl cellulose (HEC) yipolymer eguquguqukayo esetyenziswa ngokubanzi kuwo wonke amashishini ahlukeneyo. Ngelixa ukuzinza kwayo kwe-pH ngokuqhelekileyo kunamandla kuluhlu olubanzi, ukugqithiswa kwe-pH kunokuchaphazela ukusebenza kwayo kunye nokuzinza. Ukuqonda ukuxhomekeka kwe-pH ye-HEC kubalulekile ekuqulunqeni iimveliso ezisebenzayo kunye nezizinzileyo kumayeza, izithambiso, iipeyinti, i-adhesives, kunye neemveliso zokutya. Ngokuqwalasela ukuhambelana kwe-pH kunye nokusebenzisa izicwangciso ezifanelekileyo zokuqulunqa, i-HEC inokuqhubeka isebenza njengesithako esibalulekileyo kwiintlobo ezahlukeneyo zezicelo.