IHydroxypropylmethylcellulose (HPMC) sisilulo seselulosi esisetyenziswa ngokuqhelekileyo kumashishini ahlukeneyo, kubandakanywa amayeza, ulwakhiwo kunye nokutya. I-viscosity yayo inokwahluka ngokuxhomekeke kwizinto ezifana nobunzima bayo bemolekyuli, iqondo lokutshintshwa, kunye nokugxilwa kwesisombululo.
Intshayelelo ngeHydroxypropyl Methylcellulose (HPMC)
I-Hydroxypropyl methylcellulose yi-semi-synthetic polymer efunyenwe ngokuguqulwa kweekhemikhali zeselulosi. Ngenxa yeempawu zayo ezizodwa, isetyenziswa ngokubanzi njenge-thickener, i-agent ye-gelling, ifilimu yangaphambili kunye ne-stabilizer kwizicelo ezahlukeneyo.
Ubume bemolekyuli kunye nokwakheka
I-HPMC iqulethe umqolo weselulosi one-hydroxypropyl kunye ne-methoxy substituents. Iqondo lokutshintshela (DS) libhekisa kwiavareji yenani lamalungu kwiyunithi yeanhydroglucose kwikhonkco leselulosi. Ixabiso elithile le-DS lichaphazela izinto eziphathekayo kunye neekhemikhali ze-HPMC.
HPMC viscosity
I-Viscosity yiparameter ebalulekileyo ye-HPMC, ngakumbi kwizicelo ezisebenzisa iimpawu zayo zokujiya kunye ne-gelling.
I-viscosity yezisombululo ze-HPMC ichatshazelwa zizinto ezininzi:
1. Ubunzima bemolekyuli
Ubunzima bemolekyuli ye-HPMC ichaphazela i-viscosity yayo. Ngokubanzi, ubunzima bemolekyuli ephezulu ye-HPMCs ikholisa ukuvelisa izisombululo eziphezulu ze-viscosity. Kukho amabanga ahlukeneyo e-HPMC kwimarike, ngalinye linoluhlu lwalo lobunzima bemolekyuli.
2. Isidanga sokutshintshwa (DS)
Amaxabiso e-DS e-hydroxypropyl kunye namaqela e-methoxy achaphazela ukunyibilika kunye ne-viscosity ye-HPMC. Amaxabiso aphezulu e-DS ngokubanzi akhokelela ekwandeni kokunyibilika kwamanzi kunye nezisombululo ezityebileyo.
3. Ukugxininisa
Ukuxinwa kwe-HPMC kwisisombululo yinto ephambili echaphazela i-viscosity. Njengoko ugxininiso lukhula, i-viscosity idla ngokunyuka. Obu budlelwane buhlala buchazwa yi-equation ye-Krieger-Dougherty.
4. Ubushushu
Ubushushu bukwachaphazela i-viscosity yezisombululo ze-HPMC. Ngokuqhelekileyo, i-viscosity iyancipha njengoko ubushushu bukhula.
Iindawo zesicelo
I-Pharmaceuticals: I-HPMC isetyenziswa ngokuqhelekileyo ekuqulunqweni kwamachiza, kubandakanywa iipilisi kunye nezisombululo ze-ophthalmic, apho ukukhululwa okulawulwayo kunye ne-viscosity kubaluleke kakhulu.
Ulwakhiwo: Kushishino lokwakha, i-HPMC isetyenziswa njengento etyebisayo kwiimveliso ezisekwe kwisamente ukuphucula ukusebenza kunye nokugcinwa kwamanzi.
Ishishini lokuTya: I-HPMC isetyenziswa njenge-thickener, stabilizer kunye ne-emulsifier kwizicelo zokutya.
I-viscosity ye-hydroxypropyl methylcellulose yipropati eyinkimbinkimbi echaphazelekayo kwizinto ezininzi ezifana nesisindo se-molecular, i-degree of substitution, i-concentration kunye neqondo lokushisa. Amabanga ahlukeneyo e-HPMC ayafumaneka ukuze ahambelane nezicelo ezithile, kwaye abavelisi babonelela ngamaxwebhu edatha yobugcisa echaza uluhlu lwe-viscosity yebakala ngalinye phantsi kweemeko ezahlukeneyo. Abaphandi kunye nabaqulunqi kufuneka bathathele ingqalelo le miba ukuze balungelelanise iipropati ze-HPMC ukuhlangabezana neemfuno zezicelo zabo ezijoliswe kuzo.
Ixesha lokuposa: Jan-20-2024