I-Hydroxypropyl Cellulose (HPC) yi-excipient esetyenziswa ngokubanzi kwintsimi yamachiza eneempawu ezahlukeneyo zokusebenza. Isetyenziswa ikakhulu kumalungiselelo aqinileyo afana neetafile kunye neecapsules. Njenge-semi-synthetic cellulose derivative, i-HPC yenziwe ngokuzisa amaqela e-hydroxypropyl kwisakhiwo se-cellulose ye-molecular, enika i-solubility egqwesileyo, ukunamathela kunye neempawu zokwenza ifilimu, okwenza kube yinto eguquguqukayo kwi-tablet formulations.
1. Izityebi kunye nezibophelelo
I-HPC, njenge-thickener kunye ne-binder, inokunceda i-particle bond kunye nefom ngexesha lenkqubo ye-granulation emanzi yokuvelisa ithebhulethi. Inonamathela olomeleleyo kwaye inokubambelela amasuntswana omgubo ocolekileyo kunye ngegranulation emanzi ukwenza amasuntswana ahamba kakuhle kunye noxinzelelo. Ezi ngqungquthela zilula ukwenza kwaye zine-compressibility efanelekileyo ngexesha lethebhulethi, okubangelwa iipilisi eziphezulu. Kwinkqubo yokulungiselela ithebhulethi, ukongezwa kwee-binders kunokuqinisekisa ubunzima, ukuchasana nokutyumza kunye ne-brittleness ephantsi yamacwecwe.
2. Iiarhente eziLawulwayo zokuKhululwa
Impembelelo yokukhululwa elawulwayo ye-HPC kwiipilisi yenye yezona zicelo ezibalulekileyo. Ngenxa yokuvuvukala kwayo kunye neempawu ze-viscosity emanzini, i-HPC inokwenza ifilimu ye-hydration kumphezulu wamacwecwe, ukunciphisa izinga lokukhululwa kweziyobisi, ngaloo ndlela ifezekisa umphumo wokulibazisa ukukhutshwa kweziyobisi. Kwiipilisi ezikhutshwayo ezilawulwayo, i-HPC inokulungelelanisa ngokufanelekileyo izinga lokukhutshwa kweziyobisi ngokuhlengahlengisa ubunzima bayo be-molecular kunye nesixa sokongeza, ngaloo ndlela yandisa ixesha lesenzo seyeza, ukunciphisa ukuphindaphinda kokulawulwa kweziyobisi, kunye nokuphucula ukuthotyelwa kwesigulane. Umaleko wayo we-hydration unyibilika ngokuthe ngcembe ngokuhamba kwexesha, kwaye izinga lokukhutshwa kwechiza aliguquguquki ngokwentelekiso, oko kuyenza ibe nethemba eligqwesileyo lesicelo kwiipilisi ezikhutshwa ngokuzinzileyo.
3. I-arhente yokwenza ifilimu
Iimpawu zefilimu ze-HPC zenza ukuba zisetyenziswe ngokubanzi kwiipilisi zeepilisi, ngokukodwa izinto zokugubungela amanzi. Ukugquma umphezulu wethebhulethi ngefilimu ye-HPC kunokwenza umaleko obhityileyo kunye noxineneyo okhuselayo, ongenako ukufihla ubukrakra bechiza kuphela kwaye uphucule incasa, kodwa nokukhusela ichiza kunye nokwandisa ukuzinza kwechiza. Ngenxa yokuba i-HPC inokucaca kakuhle kunye nokuguquguquka, ifilimu eyenzayo ifana kwaye igudileyo, kwaye inefuthe elincinane kwimbonakalo yethebhulethi. Ukongezelela, ifilimu ye-HPC ine-solubility efanelekileyo kwi-gastrointestinal tract kwaye ayiyi kuba nefuthe elibi kwi-bioavailability yeyeza.
4. Isizinzi
Impembelelo yokukhusela ye-HPC nayo ibaluleke kakhulu ekusetyenzisweni kweepilisi, ngakumbi ezo ziyobisi ezithintekayo ekukhanyeni kunye nokufuma. I-HPC inokwahlula ngokufanelekileyo impembelelo yomoya kunye nokufuma, kwaye ithintele ichiza ekuwohlokeni okanye ukungasebenzi kwe-oxidative ngenxa yokufuma. Ngokukodwa xa i-tablet yokugqoka ilungiselelwe kwi-solvents ye-organic, ukuzinza kunye ne-inertness yekhemikhali ye-HPC ikhusela ukuba ingaphenduli kunye nezithako zeziyobisi ezisebenzayo, ngaloo ndlela iqinisekisa ukuzinza kunye nobomi beshelufu yeziyobisi.
5. Ukungavumelani
Nangona i-HPC isetyenziswa kakhulu njenge-ejenti yokukhululwa elawulwayo, inokusetyenziswa njenge-disintegrant kwezinye iipilisi zokukhulula ngokukhawuleza. I-Low-viscosity HPC inokunyibilika ngokukhawuleza kwaye idumbe emva kokudibana namanzi, okukhokelela ekuqhekekeni ngokukhawuleza kwethebhulethi, ngaloo ndlela ikhuthaza ukuchithwa kunye nokufunxa ichiza kwindlela yesisu. Esi sicelo sifanelekile kumachiza athile ekufuneka asebenze ngokukhawuleza. I-HPC inokufikelela kwiimpawu ezihlukeneyo zokuhlukana kwiindlela ezahlukeneyo zethebhulethi ngokulungelelanisa ubunzima bayo be-molecular, ubungakanani bokongeza kunye nezinye izinto ezincedisayo.
6. Ukusetyenziswa kwiipilisi ezichithwa ngomlomo
I-solubility yamanzi kunye ne-viscosity ye-HPC iphinda ibonise imiphumo emihle kwi-tablet disintegrating tablets (ODT). Kule thebhulethi, i-HPC inokunyusa izinga lokuchithwa kwethebhulethi kwisigxina somlomo, okwenza kube lula ukuba izigulane, ngakumbi abantu abadala okanye abantwana, baginye. I-solubility yamanzi ye-HPC yenza ukuba ichithe kwaye ichithe ngexesha elifutshane, ngelixa i-viscosity yayo iqinisekisa amandla okwakhiwa kwethebhulethi kwaye ikhusela ukuba iphule ngexesha lokuvelisa kunye nokugcinwa.
7. Intsebenziswano nabanye abancedisi
I-HPC iphinde ibe nokuhambelana kakuhle kwe-excipient kwi-tablet formulations kwaye inokubambisana nezinye izinto ezincedisayo (ezifana ne-microcrystalline cellulose, i-carboxymethyl cellulose, njl.) ukuphucula ukusebenza kwethebhulethi. Ngokomzekelo, xa isetyenziswe ngokudibanisa ne-microcrystalline cellulose, i-HPC inokuphucula i-fluidity kunye nokufana kwethebhulethi ngelixa iqinisekisa ubunzima bethebhulethi; xa isetyenziswe ngokudibanisa nezinye izinto zokuncamathelisa, inokuphucula ngakumbi ukunamathela kwethebhulethi, iphucule umgangatho wegranulation kunye nesiphumo sokubumba.
8. Iimeko ezichaphazelayo kunye nokunciphisa
Nangona i-HPC ineenzuzo ezininzi kwiipilisi, umphumo wokusetyenziswa kwayo uchatshazelwa zizinto ezininzi, ezifana nobunzima bemolekyuli, ugxininiso, ukufuma, njl njl. Ubukhulu be-molecular weight HPC, buphezulu i-viscosity, kunye namandla okulawula ukulawula izinga lokukhululwa kweziyobisi; kwangaxeshanye, ukufuma okugqithisileyo kokusingqongileyo kunokubangela ukuba ithebhulethi ifunxe ukufuma, echaphazela ukuzinza kwayo. Ngoko ke, xa usebenzisa i-HPC, kuyimfuneko ukuba ukhethe ngokufanelekileyo iiparitha ezifanelekileyo ukuqinisekisa umphumo ongcono kakhulu ekuqulunqweni kwethebhulethi.
I-Hydroxypropyl cellulose inemisebenzi emininzi ekuqulunqweni kwethebhulethi, kubandakanywa i-thickener, i-binder, i-ejenti yokukhululwa elawulwayo, ifilimu yangaphambili, i-stabilizer kunye ne-disintegrant, enokuphucula ngokufanelekileyo umgangatho weepilisi kunye nokusebenza kokukhululwa kweziyobisi. Ngokweempawu ezithile zamachiza kunye neemfuno zokuqulunqa, ubunzima beemolekyuli ezahlukeneyo kunye needosi ze-HPC zinokuhlengahlengisa ngokuguquguqukayo i-viscosity, ukuchithwa kunye nesantya sokukhululwa kwamacwecwe, okwenza kube nexabiso elibalulekileyo lesicelo kwishishini lamachiza.
Ixesha lokuposa: Nov-04-2024