IHydroxypropyl Methyl Cellulose (HPMC), ekwaziwa ngegama lezorhwebo elithi hypromellose, yipolima yokwenziwa ephuma kwiselulosi yendalo. Owona mthombo weselulosi kwimveliso ye-HPMC yintlama yomthi okanye umqhaphu. Inkqubo yokwenziwa kwemveliso ibandakanya ukuguqulwa kweekhemikhali zeselulosi ngokusebenzisa i-etherification, ukwazisa i-hydroxypropyl kunye namaqela e-methyl kumqolo we-cellulose.

Ukuveliswa kweHPMC kubandakanya amanyathelo amaninzi:

1. Ukukhutshwa kweCellulose:
   • I-cellulose ifumaneka kwimithombo yezityalo, ngokukodwa i-pulp yomthi okanye ikotoni. I-cellulose ikhutshwe kwaye ihlanjululwe ukwenza i-cellulose pulp.
2. Ukwenziwa kweAlkalization:
   • I-pulp ye-cellulose iphathwa ngesisombululo se-alkaline, ngokuqhelekileyo i-sodium hydroxide (NaOH), ukuze kusebenze amaqela e-hydroxyl kwi-cellulose chain.
3. Etherification:
   • I-Etherification linyathelo eliphambili kwimveliso ye-HPMC. I-alkalized cellulose iphendulwa ngepropylene oxide (yamaqela e-hydroxypropyl) kunye ne-methyl chloride (yamaqela e-methyl) ukwazisa la maqela e-ether kwi-cellulose backbone.
4. Ukungathathi hlangothi kunye nokuhlamba:
   • Isiphumo se-cellulose eguqulwayo, ngoku i-Hydroxypropyl Methyl Cellulose, ingena kwinkqubo yokungathathi hlangothi ukususa nayiphi na i-alkali eseleyo. Emva koko ihlanjwe ngokucokisekileyo ukuze kupheliswe ukungcola kunye nemveliso.
5. Ukomisa kunye nokuSila:
   • I-cellulose eguquliweyo yomiswa ukuze isuse ukufuma okugqithisileyo kwaye emva koko igalelwe ibe ngumgubo ocolekileyo. Ubungakanani be-particle bunokulawulwa ngokusekelwe kwisicelo esijoliswe kuyo.

Imveliso ye-HPMC ebangelwa ngumgubo omhlophe okanye omhlophe omhlophe kunye namaqondo ahlukeneyo e-hydroxypropyl kunye ne-methyl substitution. Iimpawu ezithile ze-HPMC, ezifana nokunyibilika kwayo, i-viscosity, kunye nezinye iimpawu zokusebenza, zixhomekeke kwiqondo lokutshintshela kunye nenkqubo yokuvelisa.

Kubalulekile ukuqaphela ukuba i-HPMC yi-semi-synthetic polymer, kwaye ngelixa iphuma kwiselulosi yendalo, ifumana uhlengahlengiso olubalulekileyo lweekhemikhali ngexesha lenkqubo yokuvelisa ukufezekisa iipropathi zayo ezinqwenelekayo kwizicelo ezahlukeneyo zemizi-mveliso.