Umxhasi woPhando
IHydroxypropyl methylcellulose (HPMC) imhlophe okanye ibisi emhlophe, ayinavumba, ayinancasa, ifayibha okanye igranule, ukwehla kobunzima xa isomiswa akudluli kwi-10%, inyibilika kumanzi abandayo kodwa hayi amanzi ashushu, kancinci emanzini ashushu isisombululo se-viscous colloidal, esiba sisisombululo xa sipholile, kwaye sibe yijeli xa ishushu. I-HPMC ayinyibiliki kwi-ethanol, i-chloroform kunye ne-ether. Inyibilika kwi-solvent edibeneyo ye-methanol kunye ne-methyl chloride. Ikwanyibilika kwisinyibilikisi esixubeneyo se-acetone, i-methyl chloride kunye ne-isopropanol kunye nezinye izinyibilikisi eziphilayo. Isisombululo saso samanzi sinokunyamezela ityuwa (isisombululo sayo se-colloidal asichithwanga ngetyuwa), kwaye i-pH ye-1% yesisombululo samanzi ngu-6-8. I-molecular formula ye-HPMC yi-C8H15O8-( C10H18O6) -C815O, kwaye ubunzima be-molecular mass malunga ne-86,000.
I-HPMC inonyibiliko olubalaseleyo lwamanzi kumanzi abandayo. Iyakwazi ukuchithwa kwisisombululo esicacileyo kunye nokuvuselela okuncinci emanzini abandayo. Ngokuchasene noko, ayinyibiliki kumanzi ashushu ngaphezulu kwe-60 ℃ kwaye inokudumba kuphela. Yi-ether ye-cellulose engeyiyo ionic. Isisombululo saso asinayo i-ionic intlawulo, ayifuni ukusebenzisana neetyuwa zetsimbi okanye i-ionic organic compounds, kwaye ayihambisani nezinye izinto eziluhlaza ngexesha lokulungiselela; inezixhobo ezinamandla ezichasene ne-allergies, kunye nokunyuka kweqondo lokutshintshwa kwisakhiwo se-molecular, yayo Iyakwazi ukumelana nokwaliwa kunye nokuzinza; ikwayi-inert ye-metabolically. Njengomxhasi wamachiza, ayenzi i-metabolized okanye ifunnwe. Ngoko ke, ayiboneleli ngeekhalori kumayeza kunye nokutya. Ikhalori ephantsi, ayinatyuwa, kwaye ayinayo ityuwa kwizigulana ezinesifo seswekile. Iziyobisi ze-Allergenic kunye nokutya zinokusetyenziswa okukodwa; lizinzile kwi-acids kunye ne-alkali, kodwa ukuba ixabiso le-PH lidlula i-2 ~ 11 kwaye lichaphazelekayo ngamaqondo okushisa aphezulu okanye linexesha elide lokugcina, i-viscosity yayo iya kuncipha; isisombululo sayo samanzi sinokubonelela ngomsebenzi we-Surface, ebonisa ukunyanzeliswa komphezulu ophakathi kunye noxinzelelo lwangaphakathi; ine-emulsification esebenzayo kwinkqubo yesigaba sesibini, ingasetyenziselwa njenge-stabilizer esebenzayo kunye ne-colloid ekhuselayo; isisombululo sayo samanzi sineempawu ezibalaseleyo zokwenza ifilimu, ithebhulethi kunye nepilisi Isixhobo esihle sokwambathisa. Ukufakwa kwefilimu eyenziwe yiyo kunenzuzo yokungabi mbala kunye nokuqina. Ukongeza i-glycerin kunokuphucula iplastiki yayo.
Iimveliso ze-QualiCell HPMC zinokuphucuka ngezi propati zilandelayo kwi-Pharmaceutical Excipient:
·Yakube inyibilika emanzini yaza yatshintshatshintsha ngesinyibilikisi, i-HPMC yenza ifilim ebonisa elubala ngamandla amakhulu okuqina.
·Ukwandisa amandla okubopha .
·I-Hydrophilic matrix esetyenziswa kunye ne-HPMC hydrates ukwenza umaleko wejeli, ukulawula ipateni yokukhupha ichiza.
| Cebisa iBanga: | Cela i-TDS |
| HPMC 60AX5 | Cofa apha |
| HPMC 60AX15 | Cofa apha |