IHydroxypropyl methylcellulose (HPMC) yikhompawundi enemisebenzi emininzi esetyenziswa kakhulu kumashishini ahlukeneyo ngenxa yobume bayo beekhemikhali ezizodwa kunye neempawu.
1. Ukwakheka kweekhemikhali:
a.Umqolo weCellulose:
I-HPMC yi-cellulose derivative, ethetha ukuba iphuma kwi-cellulose, i-polysaccharide yendalo efumaneka kwiindonga zeeseli zezityalo.I-Cellulose iqulethe iiyunithi eziphinda-phindayo ze-β-D-glucose ezidityaniswe yi-β(1→4) iibhondi ze-glycosidic.
b.Ukutshintshwa:
Kwi-HPMC, i-hydroxyl (-OH) i-moiety ye-cellulose backbone ithathelwa indawo ngamaqela e-methyl kunye ne-hydroxypropyl.Olu tshintsho lwenzeka ngokusabela kwe-etherification.IDegree of substitution (DS) ibhekisa kwiavareji yenani lamaqela ehydroxyl afakwe endaweni yeyunithi yeglucose kwikhonkco leselulosi.I-DS yamaqela e-methyl kunye ne-hydroxypropyl yahlukile, echaphazela ukusebenza kwe-HPMC.
2. Ukudibanisa:
a.Etherification:
I-HPMC yenziwe nge-etherification reaction ye-cellulose kunye ne-propylene oxide kunye ne-methyl chloride.Inkqubo ibandakanya ukuphendula i-cellulose ngepropylene oxide ukwazisa amaqela e-hydroxypropyl kwaye emva koko nge-methyl chloride ukwazisa amaqela e-methyl.
b.Inqanaba lolunye ulawulo:
I-DS ye-HPMC inokulawulwa ngokulungelelanisa iimeko zokusabela ezifana nobushushu, ixesha lokuphendula, kunye noxinzelelo lwe-reactant.
3. Ukusebenza:
a.Ukunyibilika:
I-HPMC iyanyibilika emanzini kunye nezinye izinyibilikisi eziphilayo, ezifana ne-methanol kunye ne-ethanol.Nangona kunjalo, ukunyibilika kwayo kuncipha ngokunyuka kobunzima bemolekyuli kunye nenqanaba lokuthatha indawo.
b.Ukwenziwa kwefilimu:
I-HPMC yenza ifilimu ecacileyo, eguquguqukayo xa inyibilikiswa emanzini.Ezi filimu zinamandla omatshini kunye neempawu zokuthintela.
C. Viscosity:
Izisombululo ze-HPMC zibonisa ukuziphatha kwe-pseudoplastic, okuthetha ukuba i-viscosity yabo iyancipha ngokunyuka kwesantya sokucheba.I-viscosity yezisombululo ze-HPMC ixhomekeke kwizinto ezifana noxinaniso, ubunzima be-molecular, kunye neqondo lokuthatha indawo.
d.Ugcino lwamanzi:
Enye yezinto eziphambili ze-HPMC kukukwazi ukugcina amanzi.Le propati ibaluleke kakhulu kwizicelo ezahlukeneyo ezifana nemathiriyeli yokwakha, apho i-HPMC isetyenziswa njenge-ejenti yokuqina kunye nokugcina amanzi.
e.Ukuncamathela:
I-HPMC isoloko isetyenziswa njengento yokuncamathelisa kumashishini ahlukeneyo ngenxa yokukwazi ukwenza iibhondi eziqinileyo kwii-substrates ezahlukeneyo.
4. Isicelo:
a.Umzi mveliso wamachiza:
Kumayeza, i-HPMC isetyenziswa njenge-binder, i-ejenti yokugquma ifilimu, i-ejenti yokukhululwa elawulwayo, kunye ne-viscosity modifier kwi-tablet formulations.
b.Ishishini lokwakha:
I-HPMC yongezwa kwiidaka ezisekelwe kwi-samente, i-gypsum-based plasters kunye ne-adhesives ye-tile ukuphucula ukusebenza, ukugcinwa kwamanzi kunye nokubambelela.
C. ishishini lokutya:
Kushishino lokutya, i-HPMC isetyenziswa njenge-thickener, stabilizer kunye ne-emulsifier kwiimveliso ezifana neesosi, iilokhwe kunye ne-ayisikrimu.
d.Iimveliso zokhathalelo lomntu:
I-HPMC isetyenziswa njenge-thickener, i-emulsifier kunye ne-ejenti yokwenza ifilimu kwiimveliso zokhathalelo lomntu ezifana neeshampu, iiloshini kunye neekhrimu.
e.Iipeyinti kunye neeNqaku:
Kwiipeyinti kunye neengubo, i-HPMC isetyenziselwa ukuphucula i-pigment dispersion, ulawulo lwe-viscosity kunye nokugcinwa kwamanzi.
IHydroxypropylmethylcellulose (HPMC) yikhompawundi eguquguqukayo enoluhlu olubanzi lwezicelo kumashishini ahlukeneyo.Ukwakhiwa kweekhemikhali ezikhethekileyo, ukudibanisa kunye neempawu zenza ukuba ibe yinto ebalulekileyo kumayeza, izinto zokwakha, ukutya, iimveliso zokunyamekela komntu kunye neepeyinti / iingubo.Ukuqonda iimpawu ze-HPMC kuvumela usetyenziso olulungiselelweyo kwiinkalo ezahlukeneyo, igalelo ekusetyenzisweni kwayo ngokubanzi kunye nokubaluleka kwiinkqubo zokuvelisa zanamhlanje.
Ixesha lokuposa: Feb-22-2024