IHydroxypropylmethylcellulose (HPMC) yipolima enyibilikayo emanzini esetyenziswa kakhulu kumashishini ahlukeneyo afana namayeza, ukutya, izinto zokuthambisa, kunye nokwakha.I-HPMC yaziwa ngeempawu zayo ezibalaseleyo zokugcina amanzi, iyenza ibe sisithako esifanelekileyo kwizicelo ezininzi.Kweli nqaku, sivavanya izinto ezichaphazela ukugcinwa kwamanzi kwe-HPMC kunye nendlela yokuphucula ezi zinto ukuze kwandiswe ukusebenza kwazo.
1. Ubunzima bemolekyuli
Ubunzima bemolekyuli ye-HPMC idlala indima ebalulekileyo kwiindawo zokugcina amanzi.Ukuphakama kobunzima bemolekyuli, ubukhulu bomthamo wokugcina amanzi.Oku kungenxa yokuba ubunzima obuphezulu bemolekyuli i-HPMC ine-viscosity ephezulu, eyenza ukuba yenze ifilimu engqindilili kumphezulu we-substrate, ngaloo ndlela inciphisa ilahleko yamanzi.Ngoko ke, kwizicelo apho ukugcinwa kwamanzi kubaluleke kakhulu, i-HPMC ephezulu ye-molecular weight iyacetyiswa.
2. Isidanga sokutshintshwa
Iqondo lokutshintsha (DS) libhekisa kwinani le-hydroxypropyl kunye namaqela e-methyl kwimolekyuli ye-HPMC.Xa iphezulu i-DS, kokukhona umthamo wokugcina amanzi umkhulu.Oku kungenxa yokuba i-hydroxypropyl kunye namaqela e-methyl anyusa ukunyibilika kwe-HPMC emanzini kunye nokuphucula amandla ayo okwenza ijeli-efana nokungaguquguquki okunokwamkela iimolekyuli zamanzi.Ngoko ke, kwizicelo apho ukugcinwa kwamanzi kuyinto ebaluleke kakhulu, i-HPMC enezinga eliphezulu lokutshintshwa kunconywa.
3. Ubushushu kunye nokufuma
Ubushushu kunye nokufuma zizinto ezibalulekileyo ezichaphazela ukugcinwa kwamanzi kwe-HPMC.Ubushushu obuphezulu kunye nokufuma okuphantsi kuya kubangela ukuba amanzi akwifilimu ye-HPMC abe ngumphunga ngokukhawuleza, okukhokelela ekugcinweni kakubi kwamanzi.Ngoko ke, kucetyiswa ukugcina i-HPMC kwindawo epholileyo neyomileyo ukuze kugcinwe iimpawu zayo zokugcina amanzi.
4. ixabiso le-pH
I-pH ye-substrate ikwadlala indima ebalulekileyo ekugcineni amanzi e-HPMC.I-HPMC isebenza kakhulu kwindawo engathathi hlangothi ukuya kwindawo eneasidi kancinane.Xa i-pH ye-matrix iphezulu, ukunyibilika kwe-HPMC kunokuncitshiswa kwaye umphumo wokugcinwa kwamanzi uya kuncitshiswa.Ngoko ke, kucetyiswa ukuba uvavanye i-pH ye-substrate kwaye uyilungelelanise kuluhlu olufanelekileyo lokugcinwa kwamanzi ngokufanelekileyo.
5. Ukugxininisa
Uxinaniso lwe-HPMC luchaphazela neempawu zalo zokugcina amanzi.Ngokubanzi, ukuphakama koxinzelelo lwe-HPMC, kungcono ukugcinwa kwamanzi.Nangona kunjalo, kwiindawo eziphezulu kakhulu, i-viscosity ye-HPMC inokuba phezulu kakhulu, okwenza kube nzima ukuyifaka kunye nokusabalalisa ngokulinganayo kwi-substrate.Ke ngoko, kuyacetyiswa ukuba kuvavanywe eyona nto iphezulu ye-HPMC kwisicelo ngasinye ukuze kuphunyezwe ukugcinwa kwamanzi.
Ukuqukumbela, i-HPMC ibe yinto ebalulekileyo ngenxa yeempawu zayo zokugcina amanzi kwaye idlala indima ephambili kumashishini ahlukeneyo.Izinto ezichaphazela ukugcinwa kwamanzi, ezifana nobunzima be-molecular, i-degree of substitution, iqondo lokushisa kunye nomswakama, i-pH kunye nokugxininiswa, kunokulungiswa ukuze kwandiswe ukusebenza kwayo.Ngokuqonda ezi zinto, sinokuqinisekisa ukuba ii-HPMCs zifikelela kwisakhono sazo esipheleleyo, zenza ukuba ukudalwa kweemveliso ezilungiselelwe iipropati zokugcina amanzi.
Ixesha lokuposa: Jul-04-2023