Uyifakela njani amanzi kwi-HPMC?

IHydroxypropyl methylcellulose (HPMC) yipolymer eguquguqukayo esetyenziswa ngokubanzi kumashishini ahlukeneyo, kubandakanywa amayeza, izinto zokuthambisa, ukutya kunye nokwakha.Ukukwazi ukwenza iijeli, iifilimu, kunye nezisombululo kuyenza ixabiseke kwizicelo ezininzi.I-Hydration ye-HPMC linyathelo elibalulekileyo kwiinkqubo ezininzi, njengoko ivumela i-polymer ukuba ibonise iimpawu zayo ezifunekayo ngokufanelekileyo.

1. Ukuqonda i-HPMC:

I-HPMC iphuma kwi-cellulose kwaye yenziwa ngokunyanga i-cellulose nge-propylene oxide kunye ne-methyl chloride.Ibonakaliswa yi-solubility yayo yamanzi kunye nokukwazi ukwenza iigels ezicacileyo, eziguqulwa nge-thermal.Iqondo le-hydroxypropyl kunye ne-methoxyl substitution lichaphazela iimpawu zayo, kuquka ukunyibilika, i-viscosity, kunye nokuziphatha kwe-gelation.

2. Ukubaluleka kokufakwa kwamanzi:

Ukufakwa kwamanzi kubalulekile ukuze uvule ukusebenza kwe-HPMC.Xa i-HPMC ifakwe emanzini, ifunxa amanzi kunye nokudumba, okukhokelela ekubunjweni kwesisombululo se-viscous okanye ijeli, ngokuxhomekeke kugxininiso kunye neemeko.Le meko ye-hydrated yenza ukuba i-HPMC yenze imisebenzi ejoliswe kuyo, efana nokutyeba, i-gelling, ukwenza ifilimu, kunye nokugcina ukukhutshwa kwechiza.

3. Iindlela zokuGcinwa kwamanzi:

Kukho iindlela ezininzi zokufaka amanzi kwi-HPMC, ngokuxhomekeke kwisicelo kunye nesiphumo esifunekayo:

a.Ukusasazwa kwamanzi abandayo:
Le ndlela ibandakanya ukusasaza umgubo we-HPMC emanzini abandayo ngelixa uvuselela ngobumnene.
Ukusasazwa kwamanzi abandayo kuyakhethwa ukuthintela ukuhlangana kunye nokuqinisekisa ukuhanjiswa okufanayo.
Emva kokusasazwa, isisombululo siyavunyelwa ukuba siqhube ngakumbi phantsi kokuphazamiseka okuthambileyo ukufezekisa i-viscosity oyifunayo.

b.Ukusasazwa kwamanzi ashushu:
Kule ndlela, i-HPMC powder ihlakazwe emanzini ashushu, ngokuqhelekileyo kumaqondo okushisa angaphezu kwama-80 ° C.
Amanzi ashushu aququzelela ukuhanjiswa ngokukhawuleza kunye nokuchithwa kwe-HPMC, okukhokelela kwisisombululo esicacileyo.
Kufuneka kuthathelwe ingqalelo ukuphepha ukufudumeza okugqithisileyo, okunokuthoba umgangatho we-HPMC okanye kubangele ukubunjwa kwamaqhuma.

c.Ukungathathi hlangothi:
Ezinye izicelo zinokubandakanya ukungathathi hlangothi kwezisombululo ze-HPMC ngeearhente zealkaline ezifana nesodium hydroxide okanye i-potassium hydroxide.
I-neutralization ilungisa i-pH yesisombululo, esinokuchaphazela i-viscosity kunye neempawu ze-gelation ze-HPMC.

d.Utshintshiselwano lweSolvent:
I-HPMC inokuthi ifakwe emanzini ngokutshintshiselana kwe-solvent, apho isasazwe kwi-solvent exutywayo yamanzi njenge-ethanol okanye i-methanol kwaye emva koko itshintshwe ngamanzi.
Utshintshiselwano lwe-solvent lunokuba luncedo kwizicelo ezifuna ulawulo oluchanekileyo phezu kwe-hydration kunye ne-viscosity.

e.Ukukhutshwa kwamanzi kwangaphambili:
I-pre-hydration ibandakanya ukufunxa i-HPMC emanzini okanye kwi-solvent ngaphambi kokuyidibanisa kwimixube.
Le ndlela iqinisekisa i-hydration epheleleyo kwaye inokuba luncedo ekufezekiseni iziphumo ezihambelanayo, ngakumbi kwiindlela eziyinkimbinkimbi.

4. Izinto eziChaphazela ukufakwa kwamanzi:

Zininzi izinto ezinefuthe kugidilo lwe-HPMC:

a.Ubungakanani beNcam: I-HPMC egayiweyo ye-powder powder i-hydrates ngokukhawuleza kuneengqungquthela ezinqabileyo ngenxa yokwanda kwendawo.

b.Ubushushu: Amaqondo obushushu aphezulu ngokubanzi akhawulezisa ukuhanjiswa kwamanzi kodwa anokuchaphazela i-viscosity kunye nokuziphatha kwe-gelation ye-HPMC.

c.pH: I-pH ye-hydration medium inokuchaphazela imeko ye-ionization ye-HPMC kwaye ngenxa yoko i-hydration kinetics yayo kunye neempawu ze-rheological.

d.Ukuxuba: Ukuxuba okufanelekileyo okanye ukuphazamiseka kubalulekile kwi-hydration efanayo kunye nokusasazwa kwamasuntswana e-HPMC kwisinyibilikisi.

e.Ugxininiso: Uxinaniso lwe-HPMC kwi-hydration medium luchaphazela i-viscosity, amandla ejeli, kunye nezinye iimpawu zesisombululo okanye ijeli.

5. Usetyenziso:

IHydrated HPMC ifumana usetyenziso olwahlukeneyo kumashishini ahlukeneyo:

a.Uqulunqo lwamachiza: Kwimigquba yeepilisi, iimatriki ezikhutshwayo ezilawulwayo, izisombululo zamehlo, kunye nokunqunyanyiswa.

b.Iimveliso zokutya: Njenge-thickener, stabilizer, okanye i-agent-forming agent kwiisosi, iingubo, iimveliso zobisi kunye ne-confectionery.

c.Izithambiso: Kwiikhrimu, ii-lotions, iigels, kunye nezinye iifomyula zokuguqulwa kwe-viscosity kunye ne-emulsification.

d.Izinto zokwakha: Kwiimveliso ezisekelwe kwi-samente, i-adhesives tile, kunye ne-renders ukuphucula ukusebenza, ukugcinwa kwamanzi kunye nokubambelela.

6. Ulawulo loMgangatho:

I-hydration esebenzayo ye-HPMC ibalulekile ekusebenzeni kwemveliso kunye nokungaguquguquki.Amanyathelo olawulo lomgangatho angabandakanya:

a.Uhlalutyo lobungakanani beNcam: Ukuqinisekisa ukufana kokuhanjiswa kobungakanani besuntswana ukuze kuphuculwe i-hydration kinetics.

b.I-Viscosity Measurement: Ukubeka iliso kwi-viscosity ngexesha le-hydration ukufezekisa ukuhambelana okufunwayo kwisicelo esijoliswe kuyo.

c.i-pH Monitoring: Ukulawula i-pH ye-hydration medium ukunyusa ukugqithiswa kwamanzi kunye nokuthintela ukuthotywa.

d.Uvavanyo lweMicroscopic: Ukuhlolwa okubonakalayo kweesampuli ze-hydrated phantsi kwe-microscope ukuvavanya ukusabalalisa kwamasuntswana kunye nokuthembeka.

7. Isiphelo:

Ukufakwa kwamanzi yinkqubo esisiseko ekusebenziseni iimpawu ze-HPMC kwizicelo ezahlukeneyo.Ukuqonda iindlela, izinto, kunye nemilinganiselo yokulawula umgangatho ehambelana ne-hydration ibalulekile ekuphuculeni ukusebenza kwemveliso kunye nokuqinisekisa ukuhambelana kwimiqulu.Ngokufunda kakuhle i-hydration ye-HPMC, abaphandi kunye nabaqulunqi banokuvula amandla abo apheleleyo kuluhlu olubanzi lwamashishini, ukuqhuba ukuqamba izinto ezintsha kunye nophuhliso lwemveliso.