Ukulungiselela isisombululo se-Hydroxypropyl Methylcellulose (HPMC) yinkqubo esisiseko kumashishini amayeza kunye nokutya.I-HPMC yipolymer esetyenziswa ngokuqhelekileyo kwimixube yokwaleka ngenxa yeempawu zayo ezibalaseleyo zokwenza ifilim, uzinzo, kunye nokuhambelana nezithako ezahlukeneyo ezisebenzayo.Izisombululo zokugquma zisetyenziselwa ukubonelela ngeeleyile ezikhuselayo, ukulawula iiprofayili zokukhupha, kunye nokuphucula inkangeleko kunye nokusebenza kweetafile, iipilisi, kunye nezinye iifom zedosi eqinile.
1. Izinto ezifunekayo:
IHydroxypropyl Methylcellulose (HPMC)
I-solvent (ngokuqhelekileyo amanzi okanye umxube wamanzi kunye notywala)
I-Plasticizer (ukhetho, ukuphucula ukuguquguquka kwefilimu)
Ezinye izongezo (ukuzikhethela, njengeemibala, ii-opacifiers, okanye i-anti-tacking agents)
2. Izixhobo ezifunekayo:
Ukuxuba isitya okanye isitya
I-Stirrer (imatshini okanye imagnethi)
Umlinganiselo wokulinganisa
Umthombo wokufudumeza (ukuba uyafuneka)
I-Sieve (ukuba kuyimfuneko ukususa amaqhuma)
imitha ye-pH (ukuba uhlengahlengiso lwe-pH luyimfuneko)
Izixhobo zokhuseleko (iiglavu, iiglasi, idyasi yelebhu)
3. Inkqubo:
Inyathelo 1: Ukulinganisa izithako
Ukulinganisa ubungakanani obufunekayo be-HPMC usebenzisa ibhalansi yokulinganisa.Isixa sinokwahluka ngokuxhomekeka ekugxininiseni okufunwayo kwesisombululo sokugquma kunye nobukhulu bebhetshi.
Ukuba usebenzisa iplastiki okanye ezinye izongezo, linganisa ubungakanani obufunekayo ngokunjalo.
Inyathelo lesi-2: Ukulungiswa kwesinyibilikisi
Qinisekisa uhlobo lwe-solvent oluza kusetyenziswa ngokusekelwe kwisicelo kunye nokuhambelana nezithako ezisebenzayo.
Ukuba usebenzisa amanzi njengesinyibilikisi, qinisekisa ukuba anobunyulu obuphezulu kwaye kukhethwa ukuba idistilled okanye i-deionized.
Ukuba usebenzisa umxube wamanzi kunye notywala, misela umlinganiselo ofanelekileyo ngokusekelwe kwi-solubility ye-HPMC kunye neempawu ezifunwayo zesisombululo sokugquma.
Inyathelo lesi-3: Ukudibanisa
Beka isitya sokuxuba kwi-stirrer kwaye ungeze i-solvent.
Qala ukuvuselela i-solvent ngesantya esiphakathi.
Yongeza ngokuthe ngcembe i-HPMC yomgubo owenziwe ngaphambili kwi-solvent evuselelayo ukuphepha ukugoba.
Qhubeka uvuselela de i-HPMC powder ihlakazwe ngokufanayo kwi-solvent.Le nkqubo inokuthatha ixesha elithile, ngokuxhomekeke kugxininiso lwe-HPMC kunye nokusebenza kakuhle kwezixhobo ezishukumisayo.
Inyathelo 4: Ukufudumeza (ukuba kuyafuneka)
Ukuba i-HPMC ayinyibiliki ngokupheleleyo kwiqondo lobushushu begumbi, ukufudumeza okuthambileyo kunokuba yimfuneko.
Fudumeza umxube ngelixa uvuselela de i-HPMC ichithwe ngokupheleleyo.Lumka ungagqithisi, njengoko ubushushu obugqithisileyo bunokuthoba i-HPMC okanye amanye amacandelo esisombululo.
Inyathelo lesi-5: Ukongezwa kwePlastiki kunye nezinye izongezo (ukuba ziyasebenza)
Ukuba usebenzisa i-plasticizer, yongeza kwisisombululo ngokuthe ngcembe ngelixa uvuselela.
Ngokufanayo, yongeza naziphi na izongezo ezinqwenelekayo ezinje ngemibala okanye ii-opacifiers kweli nqanaba.
Inyathelo lesi-6: Uhlengahlengiso lwe-pH (ukuba kuyimfuneko)
Jonga i-pH yesisombululo sokugquma usebenzisa imitha ye-pH.
Ukuba i-pH ingaphandle koluhlu olufunwayo ngenxa yozinzo okanye izizathu zokuhambelana, yilungelelanise ngokongeza amanani amancinci e-acidic okanye izisombululo ezisisiseko ngokufanelekileyo.
Gxuma isisombululo ngokucokisekileyo emva kokudibanisa nganye kwaye uphinde uhlolisise i-pH kuze kube yilapho umgangatho ofunekayo ufezekisiwe.
Inyathelo lesi-7: Ukuxutywa kokugqibela kunye noVavanyo
Emva kokuba zonke izinto zongezwa kwaye zixutywe ngokucokisekileyo, qhubeka uvuselela eminye imizuzu embalwa ukuqinisekisa ukuba i-homogeneity.
Yenza naziphi na iimvavanyo zomgangatho oyimfuneko ezifana nomlinganiselo we-viscosity okanye uhlolo olubonakalayo kuzo naziphi na iimpawu ze-particulate matter okanye ukuhlukana kwesigaba.
Ukuba kuyimfuneko, dlulisa isisombululo nge-sieve ukususa nayiphi na ingqungquthela eseleyo okanye iincinci ezinganyibilikiyo.
Inyathelo 8: Ugcino kunye nokuPakisha
Dlulisela isisombululo sokugquma se-HPMC esilungisiweyo kwizikhongozeli ezifanelekileyo zokugcina, kukhethwa iibhotile zeglasi e-amber okanye izikhongozeli zeplastiki ezikumgangatho ophezulu.
Bhala izikhongozeli ngolwazi oluyimfuneko olufana nenombolo yebhetshi, umhla wokulungiselela, ugxininiso, kunye neemeko zokugcina.
Gcina isisombululo kwindawo epholileyo, eyomileyo ekhuselwe ekukhanyeni kunye nokufuma ukuze ugcine uzinzo kunye nobomi beshelufu.
4. Iingcebiso kunye neNgqwalasela:
Ngalo lonke ixesha ulandela iinkqubo ezifanelekileyo zelabhoratri kunye nezikhokelo zokhuseleko xa uphethe imichiza kunye nezixhobo.
Gcina ucoceko kunye nobunyumba kuyo yonke inkqubo yokulungiselela ukuthintela ukosuleleka.
Ukuvavanya ukuhambelana kwesisombululo sokugquma kunye ne-substrate ejoliswe kuyo (iipilisi, ii-capsules) ngaphambi kwesicelo esikhulu.
Ukuqhuba izifundo zokuzinza ukuvavanya ukusebenza kwexesha elide kunye neemeko zokugcina zesisombululo sokwambathisa.
Bhala inkqubo yokulungiselela kwaye ugcine iirekhodi ngeenjongo zolawulo lomgangatho kunye nokuthotyelwa kwemithetho.
Ixesha lokuposa: Mar-07-2024