Ukuchithwa kweHydroxypropyl Methylcellulose (HPMC) emanzini yinto eqhelekileyo kumashishini ahlukeneyo, kubandakanywa amayeza, ukutya, izimonyo kunye nokwakhiwa.I-HPMC iphuma kwiselulosi eyenza i-transparent, colorless, kunye nesisombululo se-viscous xa ixutywe namanzi.Esi sisombululo sibonisa iipropathi ezizodwa ezinje ngokuqina, ukubopha, ukwenza ifilimu, kunye nokugcina ukukhutshwa kwezithako ezisebenzayo.Inkqubo yokuchithwa kwe-HPMC emanzini ibandakanya amanyathelo athile okuqinisekisa ukusasazwa okufanelekileyo kunye nokufana.
Intshayelelo nge-HPMC:
I-Hydroxypropyl Methylcellulose (HPMC) yi-ether ye-cellulose engeyiyo ionic ephuma kwi-cellulose ye-polymer yendalo.Yenziwe ngokuphatha i-cellulose ngepropylene oxide kunye ne-methyl chloride.I-HPMC isetyenziswa kakhulu kumashishini ahlukeneyo ngenxa yokwenziwa kwefilimu, ukutyeba, ukuzinzisa, kunye nokugcinwa kwamanzi.Usetyenziso oluphambili lwe-HPMC lubandakanya:
I-Pharmaceuticals: Isetyenziswe njenge-binder, ifilimu yangaphambili, i-viscosity modifier, kunye ne-ejenti yokukhululwa elawulwayo kwiipilisi, ii-capsules, i-ointments, kunye nokumiswa.
Ishishini lokuTya: Isetyenziswa njenge-thickener, stabilizer, emulsifier, kunye ne-ejenti yokugcina ukufuma kwiimveliso zokutya ezifana neesosi, ubisi, kunye nezinto ezibhakiweyo.
Ulwakhiwo: Isebenza njenge-ejenti yokugcina amanzi, i-adhesive, kunye ne-thickener kwizinto ezenziwe ngesamente, iiplaster ezenziwe nge-gypsum, kunye ne-adhesives tile.
Izithambiso: Isebenza njenge-thickener, ifilimu yangaphambili, kunye ne-emulsion stabilizer kwizinto zokuthambisa, iikhrimu, iishampu, kunye neemveliso zokhathalelo lomntu.
Inkqubo yoKuchithwa kwe-HPMC emanzini:
Ukunyibilikisa i-HPMC emanzini kubandakanya amanyathelo angundoqo aliqela ukuphumeza isisombululo esifanayo kunye nesizinzileyo:
Ukukhethwa kweBanga le-HPMC: Khetha ibakala elifanelekileyo le-HPMC ngokusekelwe kwi-viscosity efunekayo, ubungakanani bamasuntswana, kunye nenqanaba lokutshintsha.Amabanga ahlukeneyo anika amanqanaba ahlukeneyo e-viscosity kunye neempawu zokunyibilika.
Ukulungiswa kwamanzi: Sebenzisa amanzi ahlambulukileyo okanye adibeneyo ukuze ulungiselele isisombululo.Umgangatho wamanzi unokuchaphazela kakhulu inkqubo yokuchithwa kunye neempawu zesisombululo sokugqibela.Kuphephe ukusebenzisa amanzi aqinileyo okanye amanzi anobumdaka anokuphazamisana nonyibiliko.
UkuWayisha kunye nokuMeta: Viyisha ngokuchanekileyo ubungakanani obufunekayo be-HPMC usebenzisa ibhalansi yedijithali.Ugxininiso olucetyiswayo lwe-HPMC emanzini luyahluka ngokuxhomekeke kwisicelo esicetywayo.Ngokubanzi, ugxininiso olusuka kwi-0.1% ukuya kwi-5% w/w luqhelekile kuninzi lwezicelo.
Inqanaba lokuHyinwa: Tshifa i-HPMC elinganisiweyo ngokucothayo nangokulinganayo phezu kwamanzi ngelixa ushukumisa ngokuqhubekayo.Kuphephe ukongeza i-HPMC kwi-clumps enkulu ukuthintela ukubunjwa kwamaqhuma okanye i-agglomerates.Vumela i-HPMC ukuba ifake amanzi kwaye isasaze kancinci emanzini.
Ukuxuba kunye nokuphazamiseka: Sebenzisa isixhobo esifanelekileyo sokuxuba esifana ne-magnetic stirrer, i-propeller mixer, okanye i-high-chear mixer ukuququzelela ukusasazwa okufanayo kwamasuntswana e-HPMC emanzini.Gcina uphazamiseko ukuze uthintele ugwebu olugqithisileyo okanye ukubanjiswa komoya.
Ulawulo lobushushu: Jonga kwaye ulawule ubushushu ngexesha lenkqubo yokupheliswa.Kwiimeko ezininzi, ukushisa kwegumbi (20-25 ° C) kwanele ukunyibilikisa i-HPMC.Nangona kunjalo, ukunyibilika ngokukhawuleza okanye imixube ethile, amaqondo obushushu aphezulu anokufuneka.Gwema ukufudumala, njengoko kunokunciphisa i-polymer kwaye kuchaphazele iipropati zesisombululo.
Ixesha Lokupheliswa: Ukupheliswa okupheleleyo kwe-HPMC kunokuthatha iiyure ezininzi, kuxhomekeke kwibakala, ubungakanani bamasuntswana, kunye nobunzulu besiphithiphithi.Qhubeka uvuselela de isisombululo sicace, sibonakale, kwaye sikhululekile kumasuntswana abonakalayo okanye i-agglomerate.
Ukulungiswa kwe-pH (ukuba kukho imfuneko): Kwezinye iifomyula, ukulungiswa kwe-pH kunokuba yimfuneko ukuze kuphuculwe uzinzo kunye nokusebenza kwesisombululo se-HPMC.Sebenzisa ii-agent ezithintelayo ezifanelekileyo okanye uhlengahlengise i-pH usebenzisa iiasidi okanye iziseko ngokweemfuno ezithile.
Ukuhluzwa (ukuba kuyafuneka): Emva kokuchithwa okupheleleyo, hluza isisombululo se-HPMC ngesihlungo esihle se-mesh okanye iphepha lokucoca ukususa naziphi na iincinci ezinganyibilikiyo okanye ukungcola.Eli nyathelo liqinisekisa ukucaca kunye ne-homogeneity yesisombululo.
Ukugcinwa kunye nozinzo: Gcina isisombululo se-HPMC esilungisiweyo kwizikhongozeli ezicocekileyo nezingangeni moya kude nelanga elithe ngqo kunye namaqondo obushushu agqithisileyo.Izisombululo ezigcinwe ngokufanelekileyo zihlala zizinzile ixesha elide ngaphandle kotshintsho oluphawulekayo kwi-viscosity okanye ezinye iipropati.
Imiba echaphazela ukupheliswa kwe-HPMC:
Izinto ezininzi zinokuphembelela inkqubo yokupheliswa kunye neempawu zesisombululo se-HPMC:
Ubungakanani beNcam kunye neBanga: Amabanga acoliweyo e-HPMC anyibilika ngokulula ngakumbi kunamasuntswana arhabaxa ngenxa yokwanda kwendawo ephezulu kunye ne-kinetics ye-hydration ekhawulezayo.
Ubushushu: Amaqondo obushushu aphezulu akhawulezisa izinga lokuchithwa kwe-HPMC kodwa asenokukhokelela ekulahlekeni kwe-viscosity okanye ukuthotywa kwiimeko ezinzima.
I-Agitation Speed: Ukuphazamiseka okufanelekileyo kuqinisekisa ukusasazwa okufanayo kwamasuntswana e-HPMC kunye nokukhuthaza ukuchithwa ngokukhawuleza.Ukuphazamiseka okugqithisileyo kunokungenisa amaqamza omoya okanye ugwebu kwisisombululo.
Umgangatho wamanzi: Umgangatho wamanzi asetyenziselwa ukuchithwa kuchaphazela ukucaca, ukuzinza, kunye ne-viscosity yesisombululo se-HPMC.Amanzi ahlambulukileyo okanye adibeneyo akhethwa ukunciphisa ukungcola kunye neeoni ezinokuphazamisa ukuchithwa.
pH: I-pH yesisombululo inokuchaphazela ukunyibilika kunye nokuzinza kwe-HPMC.Ukulungelelanisa i-pH phakathi koluhlu olulolona lufanelekileyo lwebakala elithile le-HPMC kunokonyusa ukupheliswa kunye nokusebenza.
Amandla e-Ionic: Ukugxininiswa okuphezulu kweetyuwa okanye i-ion kwisisombululo kunokuphazamisa ukuchithwa kwe-HPMC okanye kubangele i-gelation.Sebenzisa amanzi adityanisiweyo okanye uhlengahlengise ityuwa njengoko kufuneka.
Imikhosi ye-Shear: Ukuxuba okuphezulu okanye iimeko zokucubungula kunokuchaphazela iimpawu ze-rheological kunye nokusebenza kwesisombululo se-HPMC, ngokukodwa kwizicelo zoshishino.
Iingcebiso zokulungisa ingxaki:
Ukuba ufumana ubunzima ekunyibilikeni kwe-HPMC okanye amava emiba ngomgangatho wesisombululo, qwalasela la macebiso alandelayo okusombulula ingxaki:
Yandisa ukuPhazamiseka: Ukuphucula ukuxubana okanye ukusebenzisa izixhobo ezikhethekileyo zokuxuba ukukhuthaza ukusasazwa okungcono kunye nokutshatyalaliswa kwamasuntswana e-HPMC.
Lungisa iqondo lobushushu: Lungiselela iimeko zobushushu ngaphakathi koluhlu olucetyiswayo ukuququzelela ukupheliswa ngokukhawuleza ngaphandle kokubeka esichengeni uzinzo lwepolymer.
Ukunciphisa ubungakanani beNcam: Sebenzisa amabanga aphucukileyo e-HPMC okanye uqeshe ubuchule bokunciphisa ubungakanani obufana nokusila okanye ukwenza i-micronization ukuphucula i-dissolution kinetics.
Ukulungiswa kwe-pH: Jonga i-pH yesisombululo kwaye ulungelelanise njengoko kuyimfuneko ukugcina iimeko ezifanelekileyo zokunyibilika kunye nokuzinza kwe-HPMC.
Umgangatho waManzi: Qinisekisa ukucoceka kunye nomgangatho wamanzi asetyenziselwa ukuchithwa ngokusebenzisa ukuhluzwa okufanelekileyo okanye iindlela zokucoca.
Uvavanyo lokuhambelana: Yenza izifundo zokuhambelana nezinye izithako zokuqulunqa ukuchonga nayiphi na intsebenziswano okanye ukungahambelani okunokuthi kuchaphazele ukuchithwa.
Qhagamshelana neziKhokelo zoMvelisi: Jonga iingcebiso zomenzi kunye nezikhokelo zamabakala athile e-HPMC malunga neemeko zokuchithwa, uluhlu loxinaniso, kunye neengcebiso zokusombulula ingxaki.
Ukunyibilikisa iHydroxypropyl Methylcellulose (HPMC) emanzini linyathelo elibalulekileyo kwiinkqubo ezahlukeneyo zemizi-mveliso, kubandakanywa amayeza, ukutya, ukwakhiwa, kunye nezithambiso.Ngokulandela iinkqubo ezicetyiswayo kunye nokuqwalasela izinto eziphambili ezifana nobungakanani bamasuntswana, ubushushu, ukuphazamiseka, kunye nomgangatho wamanzi, unokufikelela kwisisombululo se-HPMC esifanayo kunye nesizinzileyo kunye neempawu ezifunwayo ze-rheological.Ukongeza, iindlela zokusombulula iingxaki kunye nezicwangciso zokuphucula zinokunceda ukoyisa imiceli mngeni kunye nokuqinisekisa ukuchithwa okuyimpumelelo kwe-HPMC kwizicelo ezahlukeneyo.Ukuqonda inkqubo yokupheliswa kunye nayo
Ixesha lokuposa: Mar-09-2024