Iimpawu zeHPMC kunye nemisebenzi

I-Hydroxypropyl methylcellulose (HPMC) i-polymer esebenzayo kunye nezicelo ezibanzi kumashishini ahlukeneyo afana namayeza, ukwakhiwa, ukutya, izithambiso, njl.Nalu uphononongo olunzulu lwe-HPMC:

1. Iimpawu ze-HPMC:

Ulwakhiwo lweMichiza: I-HPMC ithathwe kwi-cellulose, ipholima yendalo efumaneka kwizityalo.Idityaniswe ngokuguqula iikhemikhali zeselulosi ngepropylene oxide kunye nemethyl chloride.Iqondo lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methoxy amisela iimpawu zayo.

Ukunyibilika: I-HPMC iyanyibilika emanzini kuluhlu olubanzi lobushushu.Ukunyibilika kuxhomekeke kwinqanaba lokutshintshwa kunye nobunzima bemolekyuli yepolymer.Amanqanaba aphezulu okutshintsha akhokelela ekwandeni kokunyibilika kwamanzi.

I-Viscosity: I-HPMC ibonisa ukuziphatha kwe-pseudoplastic okanye i-shear-thinning, oku kuthetha ukuba i-viscosity yayo iyancipha phantsi koxinzelelo lwe-shear.I-viscosity yezisombululo ze-HPMC zinokuhlengahlengiswa ngokulungelelanisa iiparamitha ezifana nobunzima bemolekyuli, iqondo lokutshintshwa, kunye nokugxila.

Ukwenziwa kweFilimu: I-HPMC yenza iifilimu ezicacileyo neziguquguqukayo xa zifakwe kwisisombululo.Iimpawu zefilimu zinokuguqulwa ngokulungelelanisa ukugxininiswa kwepolymer kunye nobukho beplastiki.

Uzinzo lwe-Thermal: I-HPMC inozinzo oluhle lwe-thermal, kunye namaqondo okushisa okubola ahlala engaphezulu kwe-200 ° C.Oku kuyenza ilungele iindlela ezahlukeneyo zokusetyenzwa, kubandakanya i-extrusion eshushu yokunyibilika kunye nokubumba inaliti.

I-Hydrophilicity: Ngenxa yobume bayo be-hydrophilic, i-HPMC inokufunxa kwaye igcine isixa esikhulu samanzi.Le propati inenzuzo kwizicelo ezifana nokuhanjiswa kweziyobisi ezilawulwayo kunye ne-agent ekhulayo kwiinkqubo ezinamanzi.

Ukuhambelana: I-HPMC iyahambelana nezinye izinto ezahlukeneyo, kubandakanywa nezinye iipolymers, iiplastiki, kunye nezithako ezisebenzayo zamachiza (APIs).Oku kuhambelana kuvumela iinkqubo ezintsonkothileyo ukuba ziqulunqwe kunye neempawu ezilungiselelwe.

IiPropati ezingezizo i-ionic: I-HPMC yipolymer engeyiyo ionic, oku kuthetha ukuba ayithwali nayiphi na intlawulo yombane.Le propati inciphisa intsebenziswano kunye neentlobo ezihlawuliswayo ekuqulunqweni kwaye ikhulise ukuzinza kwayo kwisisombululo.

2.HPMC imisebenzi:

Izibophelelo: Kwimiqulu yethebhulethi, i-HPMC isebenza njenge-binder, ikhuthaza ukunamathela phakathi kwamaqhekeza kunye nokwandisa amandla omatshini wethebhulethi.Kwakhona kunceda iipilisi ukuba ziqhekeke emva kokungena.

I-Film Coating: I-HPMC isetyenziswa ngokubanzi njenge-ejenti yokugquma ifilimu kwiipilisi kunye nee-capsules.Yenza i-uniform, i-coating ekhuselayo efihla incasa kunye nevumba lechiza, iphakamisa uzinzo, kwaye iququzelele ukuginya.

Ukukhululwa okuzinzileyo: I-HPMC ingasetyenziselwa ukulawula izinga lokukhululwa kwamachiza kwiifom zedosi yonyango.Ngokufaka amanzi ukwenza umaleko wejeli, i-HPMC inokulibazisa ukukhutshwa kweziyobisi kwaye ibonelele ngeziphumo zonyango ezizinzileyo.

I-Viscosity Modifier: Kwiinkqubo zamanzi, i-HPMC isebenza njenge-viscosity modifier okanye i-thickener.Inika ukuziphatha kokuhamba kwe-pseudoplastic, ukuphucula ukuzinza kunye nokusebenza kwesicelo sokuqulunqwa njengama-creams, i-lotions kunye neegels.

I-arhente yokumisa: I-HPMC isetyenziselwa ukuzinzisa ukumiswa kwamasuntswana anganyibilikiyo kulwelo.Ikhusela ukuhlalisa ngokunyusa i-viscosity yesigaba esiqhubekayo kunye nokuphucula i-particle dispersion.

I-Emulsifier: Ekuqulunqweni kwe-emulsion, i-HPMC izinzisa i-interface phakathi kwezigaba zeoli kunye namanzi, ukuthintela ukuhlukana kwesigaba kunye ne-emulsification.Iphucula uzinzo kunye nobomi beshelufu yeloshini kwiimveliso ezifana nekhrimu, i-ointments kunye neloshini.

Ukubunjwa kweHydrogel: I-HPMC inokwenza ii-hydrogels xa ifakwe emanzini, iyenza ibe luncedo ekubopheni amanxeba, iilensi zoqhagamshelwano, kunye neenkqubo zokuhanjiswa kweziyobisi.Ezi hydrogels zibonelela ngemekobume efumileyo yokuphulukisa isilonda kwaye zinokulayishwa ngamachiza okuhanjiswa kwendawo.

I-Agent etyebisayo: I-HPMC iqhele ukusetyenziswa njenge-arhente yokutyebisa kwiimveliso zokutya ezifana neesosi, izinxibo kunye nezimuncumuncu.Inika ukuthungwa okugudileyo kwaye yongeza incasa ngaphandle kokuguqula incasa okanye umxholo wesondlo.

Izongezo zokwakha: Kushishino lokwakha, i-HPMC isetyenziswa njenge-arhente yokugcina amanzi kwi-samente-based mortars kunye ne-plasters.Iphucula ukusebenza, ukunamathela, kunye nokunciphisa ukuqhekeka ngokucotha ukuvela kwamanzi.

Isilungisi soMphezulu: I-HPMC inokuguqula iipropathi zomphezulu we substrates eziqinileyo ezifana nephepha, amalaphu kunye neeseramikhi.Iphucula ukuprintwa, ukunamathela kunye neempawu zokuthintelwa kweengubo kunye neefilimu.

IHydroxypropylmethylcellulose (HPMC) yipolymer eguquguqukayo eneempawu ezahlukeneyo kunye nemisebenzi.Ukunyibilika kwayo, i-viscosity, isakhono sokwenza ifilim kunye nokuhambelana kwayo kuyenza ibe sisithako esibaluleke kakhulu kwizicelo ezininzi kuwo wonke amashishini.Ukusuka kumayeza ukuya kulwakhiwo, ukutya ukuya kwizinto zokuthambisa, i-HPMC iyaqhubeka nokudlala indima ebalulekileyo ekuphuculeni ukusebenza kwemveliso kunye nomgangatho.Njengoko uphando kunye nobuchwepheshe buqhubela phambili, ukuguquguquka kunye nokusetyenziswa kwe-HPMC kunokwandisa ngakumbi, ukuqhuba ukuqalwa kwezinto ezintsha kuyilo loyilo kunye nophuhliso lwemveliso.