I-Hydroxypropylmethylcellulose (HPMC), njenge-polymer ye-hydrophilic esetyenziswa ngokuqhelekileyo kwishishini lamachiza, isetyenziswa ngokubanzi kwiipilisi zeepilisi, ukuqulunqwa kokukhululwa okulawulwayo kunye nezinye iinkqubo zokuhanjiswa kweziyobisi.Enye yezinto eziphambili ze-HPMC kukukwazi ukugcina amanzi, nto leyo echaphazela ukusebenza kwayo njenge-excipient yamayeza.Kweli nqaku, siza kuphonononga izinto eziphambili ezichaphazela ukugcinwa kwamanzi kwe-HPMC, kubandakanya ubunzima bemolekyuli, uhlobo lokutshintsha, ukugxininiswa, kunye ne-pH.
ubunzima bemolekyuli
Ubunzima bemolekyuli ye-HPMC idlala indima ebalulekileyo ekumiseleni umthamo wayo wokugcina amanzi.Ngokubanzi, ubunzima bemolekyuli ephezulu ye-HPMC ingaphezulu kwe-hydrophilic kune-HPMC enobunzima bemolekyuli kwaye inokufunxa amanzi amaninzi.Oku kungenxa yokuba ubunzima beemolekyuli eziphezulu ze-HPMCs zinamatyathanga amade anokuthi abambezele kwaye enze uthungelwano olubanzi ngakumbi, ukwandisa umthamo wamanzi anokufunxwa.Nangona kunjalo, kufuneka kuqatshelwe ukuba ubunzima bemolekyuli ephezulu kakhulu ye-HPMC iya kubangela iingxaki ezinjenge-viscosity kunye nobunzima bokucubungula.
enye indlela
Enye into echaphazela amandla okugcina amanzi e-HPMC luhlobo lokutshintsha.I-HPMC iza ngeendlela ezimbini ngokubanzi: i-hydroxypropyl-substituted kunye ne-methoxy-substituted.Uhlobo olufakwe endaweni ye-hydroxypropyl lunomthamo ophezulu wokufunxa amanzi kunohlobo olufakwe endaweni ye-methoxy.Oku kungenxa yokuba iqela le-hydroxypropyl elikhoyo kwi-molecule ye-HPMC li-hydrophilic kwaye linyusa ubudlelwane be-HPMC emanzini.Ngokwahlukileyo, uhlobo olufakwe endaweni ye-methoxy lungaphantsi kwe-hydrophilic kwaye ngoko lunomthamo ophantsi wokugcina amanzi.Ngoko ke, ezinye iintlobo ze-HPMC kufuneka zikhethwe ngononophelo ngokusekelwe kwiipropati ezifunwayo zemveliso yokugqibela.
gxininisa kwi
Uxinaniso lwe-HPMC lukwachaphazela amandla ayo okugcina amanzi.Kwiindawo eziphantsi, i-HPMC ayenzi isakhiwo esifana nejeli, ngoko ke amandla okugcina amanzi aphantsi.Njengoko i-concentration ye-HPMC isanda, iimolekyuli ze-polymer zaqala ukudibanisa, zenza isakhiwo esifana nejeli.Le nethiwekhi yejeli ifunxa kwaye igcine amanzi, kwaye amandla okugcina amanzi e-HPMC ayanda ngoxinaniso.Nangona kunjalo, kufuneka kuqatshelwe ukuba ukuxinwa okuphezulu kakhulu kwe-HPMC kuya kukhokelela kwiingxaki zokuqulunqa ezifana ne-viscosity kunye nobunzima bokucubungula.Ke ngoko, ugxininiso lweHPMC olusetyenzisiweyo kufuneka luphuculwe ukufezekisa umthamo ofunekayo wogcino lwamanzi ngelixa uphepha iingxaki ezikhankanywe ngasentla.
PH ixabiso
Ixabiso le-pH yokusingqongileyo apho i-HPMC isetyenziswa khona liya kuchaphazela amandla ayo okugcina amanzi.Isakhiwo se-HPMC siqulethe amaqela e-anionic (-COO-) kunye namaqela e-hydrophilic ethylcellulose (-OH).I-ionization yamaqela -COO- ixhomekeke kwi-pH, kwaye idigri ye-ionization yabo iyanda nge-pH.Ngoko ke, i-HPMC inomthamo ophezulu wokugcina amanzi kwi-pH ephezulu.Kwi-pH ephantsi, i-COO-iqela le-protonated kwaye i-hydrophilicity yayo iyancipha, okukhokelela kumthamo ophantsi wokugcinwa kwamanzi.Ke ngoko, i-pH yokusingqongileyo kufuneka iphuculwe ukufezekisa umthamo ofunekayo wogcino lwamanzi we-HPMC.
ukuququmbela
Ukuqukumbela, amandla okugcina amanzi e-HPMC yinto ephambili echaphazela ukusebenza kwayo njenge-excipient yamayeza.Izinto eziphambili ezichaphazela amandla okugcina amanzi e-HPMC zibandakanya ubunzima be-molecular, uhlobo lokutshintsha, ugxininiso kunye nexabiso le-pH.Ngokulungelelanisa ngononophelo ezi zinto, amandla okugcina amanzi e-HPMC anokunyuswa ukufezekisa iipropati ezifunwayo zemveliso yokugqibela.Abaphandi bamachiza kunye nabavelisi kufuneka bathathele ingqalelo le miba ukuqinisekisa olona mgangatho uphezulu kunye nokusebenza kokwenziwa kwamachiza okusekwe kwi-HPMC.
Ixesha lokuposa: Aug-05-2023