Ziziphi iingenelo ze-HPMC?

IHydroxypropylmethylcellulose (HPMC) yikhompawundi eguquguqukayo neguquguqukayo yosapho lwe-cellulose ether.Ithathwe kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zesityalo.I-HPMC isetyenziswa ngokubanzi kumashishini ahlukeneyo aquka amayeza, ukutya, ulwakhiwo kunye nezithambiso ngenxa yeepropati zayo ezizodwa kunye neenzuzo ezininzi.

1. Ishishini lamachiza:

A. Ulungiselelo lokukhululwa oluzinzileyo:

I-HPMC isetyenziswa kakhulu kwishishini loxubo mayeza ngenxa yokukwazi ukwenza ijeli matrix xa ifakwe emanzini.Le propati iluncedo ngokukodwa kuphuhliso lwemixube yamachiza akhutshwa ngokuzinzileyo.Ngokulawula i-viscosity kunye nereyithi ye-gelation ye-HPMC, abavelisi bamachiza banokufikelela iiprofayili ezongeziweyo zokukhupha ichiza, baphucule ukuthotyelwa kwesigulane kunye nokunciphisa i-dosing frequency.

b.Ukugquma ifilimu encinci:

I-HPMC iqhele ukusetyenziswa njenge-arhente yokugquma ifilimu kwiipilisi.Ibonelela ngengubo egudileyo, efana neyonyusa inkangeleko yamacwecwe, ifihla incasa yechiza, kwaye iyikhusele kwizinto zokusingqongileyo.Iipropati zokwenza ifilimu ze-HPMC zinceda ukuphucula uzinzo lwamachiza kunye ne-bioavailability.

C. Ukuhanjiswa kweziyobisi okuLawulwayo:

I-biocompatibility kunye nendalo engasebenziyo ye-HPMC iyenza ilungele ukusetyenziswa kwiinkqubo zokuhanjiswa kweziyobisi ezilawulwayo.Ingasetyenziswa ngokudibeneyo nezinye iipolymers ukulungelelanisa i-kinetics yokukhululwa kweziyobisi, ukuvumela ulawulo oluchanekileyo lwamazinga okuhanjiswa kweziyobisi kunye nokunciphisa umngcipheko weziphumo ebezingalindelekanga.

d.Isibophelelo secwecwe:

I-HPMC isebenza njengesibophelelo sethebhulethi esisebenzayo, inceda ekunikezeni ukuncamathela kuqulunqo lwethebhulethi.Iqinisekisa ukudibanisa okufanelekileyo kwezithako, okubangelwa ubunzima obufanayo kunye nokunyaniseka kwamacwecwe.

2. Ishishini lokutya:

A. Ii-Thickeners kunye nee-gelling agents:

Kushishino lokutya, i-HPMC isetyenziswa njenge-thickener kunye ne-gelling agent.Inika ukutya ukuthungwa okunqwenelekayo kwaye iphucula umgangatho wayo jikelele.I-HPMC isoloko isetyenziswa kwiimveliso ezifana neesosi, iisuphu kunye nezimuncumuncu ukuphumeza ukungaguquguquki okufunekayo.

b.Ukutshintshwa kwamafutha:

I-HPMC ingasetyenziswa njengebambela lamanqatha ekutyeni okuthile, inceda ekuphuhliseni amafutha aphantsi okanye iindlela ezizezinye.Oku kubaluleke ngakumbi kumxholo wokujongana nemiba yezempilo ehambelana nokusetyenziswa kwamafutha amaninzi.

C. emulsification:

Ngenxa yeepropathi zayo emulsifying, HPMC isetyenziswa ekuveliseni ukutya emulsified.Inceda ukuzinzisa i-emulsions, ukukhusela ukuhlukana kwesigaba kunye nokuqinisekisa imveliso ye-homogeneous.

d.Iarhente yokugudisa:

I-HPMC isetyenziswa njenge-agent ekhazimlayo kwishishini lokutya ukubonelela ngokukhazimla kunye nokubukeka okukhangayo ukutyabeka kwiilekese, iziqhamo kunye nezinye iimveliso zokutya.

3. Ushishino lokwakha:

A. Isincamathelisi sethayile:

I-HPMC sisithako esiphambili kwizinto zokuncamathelisa iithayile kwaye isebenza njengesixhobo esityebileyo kunye nokugcina amanzi.Iphucula ukusebenza kodaka oludityanisiweyo, ukwenza ulwakhiwo lube lula kunye nokuphucula amandla ebhondi.

b.Udaka lwesamente:

Kwizidumbu ezisekelwe kwisamente, i-HPMC isetyenziselwa ukuphucula ukugcinwa kwamanzi, ukusebenza kunye nokubambelela.Inceda ukuphucula iipropati ezipheleleyo zodaka, okwenza kube lula ukuphatha kunye nokuqinisekisa ukunamathela okungcono kumphezulu.

C. Iikhompawundi zokuzilinganisa:

I-HPMC ifakwe kwiikhompawundi zokuzilinganisa ukulawula i-viscosity kunye nokuphucula iimpawu zokuhamba.Oku kubalulekile ukuphumeza umphezulu ogudileyo, umgangatho xa ufaka isicelo kwimigangatho.

d.I-Gypsum kunye ne-stucco:

Ukongeza i-HPMC kwi-gypsum kunye ne-stucco formulations iphucula ukunamathela, ukusebenza kunye nokugcinwa kwamanzi.Inceda ukuphucula umgangatho opheleleyo womgangatho ogqityiweyo, ukunciphisa amathuba okuqhekeka kunye nokwandisa ukuqina.

4. Ishishini lezithambiso:

A. Izityebi kwiikhrimu kunye nezinto zokuthambisa:

I-HPMC idla ngokusetyenziswa njenge-arhente etyebisayo kwiindlela zokuthambisa ezifana neekhrimu kunye nezinto zokuthambisa.Inika imveliso igudi, i-creamy texture kwaye iphucula iimpawu zayo zokuva.

b.Iiarhente zokwenza ifilimu kwiimveliso zokhathalelo lweenwele:

Kwiimveliso zokhathalelo lweenwele ezinjengeejeli zeenwele kunye neekhrimu zesitayile, i-HPMC isebenza njengearhente yokwenza ifilimu.Inceda ukwenza ifilimu eguquguqukayo, ehlala ixesha elide kwizinwele, inceda ekuphuculeni ukubamba kunye nokulawula.

C. Emulsion stabilizer:

Iimpawu zokuzinzisa ze-HPMC zenza ukuba zixabiseke kwi-emulsion formulations ukukhusela ukuhlukana kwesigaba kunye nokuqinisekisa ukuzinza kwemveliso ngexesha.

d.Ukukhutshwa okulawulwayo kwimixube yezihloko:

Ngokufana nokusetyenziswa kwayo kumachiza, i-HPMC ingasetyenziselwa ukwakheka kwe-cosmetic ukuphumeza ukukhululwa okulawulwayo kwezithako ezisebenzayo.Oku kubaluleke kakhulu kwiimveliso zokunakekelwa kwesikhumba ezifuna ukukhululwa okuqhubekayo kweekhompawundi ezincedo.

5. Izibonelelo ezongezelelweyo:

A. Ugcino lwamanzi:

I-HPMC ineempawu ezigqwesileyo zokugcina amanzi, iyenza ixabiseke kwiintlobo ngeentlobo zezicelo apho ukugcina amanqanaba okufuma kubalulekile.Oku kunenzuzo ngakumbi kwimixube ethile kushishino lolwakhiwo nakumashishini okutya nezithambiso.

b.Ukonakala kwezinto eziphilayo:

I-HPMC yipolymer enokubola ehambelana nogxininiso olukhulayo kwizinto ezinobungane nokuzinzileyo.Iimpawu zayo ze-biodegradable zinciphisa impembelelo yokusingqongileyo, iyenza ibe yinto yokuqala yokukhetha izicelo ezithile.

C. Ukuhambelana nezinye iipholima:

I-HPMC inokuhambelana kakuhle kunye neentlobo zezinye iipholima, ezivumela iinkqubo ezinzima ukuba ziqulunqwe ngokweemfuno ezithile zesicelo.

d.Ayinatyhefu kunye ne-inert:

I-HPMC ithathwa njengengeyotyhefu kunye ne-inert, iyenza ikhuseleke ekusebenziseni amayeza, ukutya, izithambiso kunye nezinye izicelo apho ukhuseleko lwabathengi lubalulekile.

IHydroxypropyl methylcellulose (HPMC) ibalasele kumashishini ahlukeneyo njengekhompawundi eguquguqukayo neluncedo.Inceda ukuqulunqa iinkqubo zokukhutshwa okulawulwayo, ukunyusa ukusebenza kokutya kunye nezithambiso, kunye nokuphucula iimpawu zemathiriyeli yokwakha, kugxininisa ukuguquguquka kwayo kunye nokubaluleka kwiinkqubo zokuvelisa zanamhlanje.Njengoko ishishini liqhubeka nokuvela, i-HPMC inokuhlala isisithako esiphambili ekuphuhliseni iimveliso ezintsha nezikumgangatho ophezulu.