IHydroxypropyl methylcellulose (HPMC) yipolymer esetyenziswa ngokuqhelekileyo kumayeza, izinto zokuthambisa, iimveliso zokutya, kunye nezinye izinto ezahlukeneyo zokusebenza kwimizi-mveliso.Isetyenziswa ngokubanzi ngenxa ye-biocompatibility yayo, i-non-toxicity, kunye nokukwazi ukuguqula iimpawu ze-rheological zezisombululo.Nangona kunjalo, kubalulekile ukuqonda indlela yokunyibilikisa i-HPMC ngokufanelekileyo ukusebenzisa iipropathi zayo ngokugqibeleleyo.
Amanzi: I-HPMC inyibilika kakhulu emanzini, iyenza ibe lukhetho olukhethiweyo kwizicelo ezininzi.Nangona kunjalo, izinga lokuchithwa linokwahluka ngokuxhomekeke kwizinto ezifana nobushushu, i-pH, kunye nebakala le-HPMC elisetyenzisiweyo.
Izinyibilikisi ze-Organic: Izinyibilikisi ezahlukeneyo zezinto eziphilayo zinokunyibilikisa i-HPMC ukuya kumanqanaba ahlukeneyo.Ezinye izinyibilikisi eziqhelekileyo ze-organic ziquka:
Utywala: I-Isopropanol (IPA), i-ethanol, i-methanol, njl. Ezi zinxilisayo zihlala zisetyenziselwa ukuqulunqa amayeza kwaye zinokunyibilikisa ngempumelelo i-HPMC.
I-acetone: I-acetone sisinyibilikisi esinamandla esinokunyibilikisa i-HPMC ngokufanelekileyo.
I-Ethyl Acetate: Yenye i-solvent ye-organic enokunyibilikisa i-HPMC ngokufanelekileyo.
I-Chloroform: I-Chloroform sisinyibilikisi esinamandla kwaye kufuneka isetyenziswe ngononophelo ngenxa yetyhefu yayo.
I-Dimethyl Sulfoxide (i-DMSO): I-DMSO yi-solvent ye-polar aprotic ekwazi ukutshabalalisa uluhlu olubanzi lwee-compounds, kuquka i-HPMC.
I-Propylene Glycol (PG): I-PG isoloko isetyenziswa njenge-co-solvent ekuqulunqweni kwamayeza.Inokunyibilikisa i-HPMC ngokufanelekileyo kwaye isoloko isetyenziswa ngokudibeneyo namanzi okanye ezinye izinyibilikisi.
I-Glycerin: I-Glycerin, ekwabizwa ngokuba yi-glycerol, sisinyibilikisi esiqhelekileyo kumayeza kunye nezithambiso.Ihlala isetyenziswa ngokudibeneyo namanzi ukunyibilikisa i-HPMC.
I-Polyethylene Glycol (PEG): I-PEG yipolymer ene-solubility egqwesileyo emanzini kunye nezinyibilikisi ezininzi ze-organic.Ingasetyenziselwa ukunyibilikisa i-HPMC kwaye ihlala isetyenziswa kwimixube yokukhutshwa okuzinzileyo.
Ii-surfactants: Ezinye ii-surfactants zinokunceda ekuchithekeni kwe-HPMC ngokunciphisa ukuxinezeleka komphezulu kunye nokuphucula ukumanzisa.Imizekelo ibandakanya i-Tween 80, i-sodium lauryl sulfate (SLS), kunye ne-polysorbate 80.
Ii-Acids ezomeleleyo okanye iziseko: Nangona zingasetyenziswanga ngokuqhelekileyo ngenxa yeenkxalabo zokhuseleko kunye nokuthotywa okunokwenzeka kwe-HPMC, ii-asidi ezinamandla (umz., i-hydrochloric acid) okanye iziseko (umzekelo, i-sodium hydroxide) inokunyibilikisa i-HPMC phantsi kweemeko ezifanelekileyo.Nangona kunjalo, iimeko ezigqithisileyo ze-pH zinokukhokelela ekuthotyweni kwepolymer.
Iiarhente ezintsonkothileyo: Ezinye ii-agent ezintsonkothileyo ezifana ne-cyclodextrins zinokwenza ii-complexes ezibandakanyiweyo kunye ne-HPMC, ezincedisa ekuchithweni kwayo kunye nokuphucula ukunyibilika kwayo.
Ubushushu: Ngokubanzi, amaqondo obushushu aphezulu anyusa izinga lokunyibilika kwe-HPMC kwizinyibilikisi ezifana namanzi.Nangona kunjalo, amaqondo obushushu aphezulu kakhulu anokuyithoba i-polymer, ngoko ke kubalulekile ukusebenza ngaphakathi komgangatho okhuselekileyo wobushushu.
I-Mechanical Agitation: Ukuvuselela okanye ukuxuba kunokuncedisa ukuchithwa kwe-HPMC ngokunyusa uqhagamshelwano phakathi kwepolymer kunye ne-solvent.
Ubungakanani beNcam: I-HPMC enomgubo ocolekileyo iya kunyibilika ngokulula ngakumbi kunamaqhekeza amakhulu ngenxa yokwanda kwendawo.
Kubalulekile ukuqaphela ukuba ukhetho lwesinyibilikisi kunye neemeko zokuchithwa kuxhomekeke kwisicelo esithile kunye neempawu ezifunwayo zemveliso yokugqibela.Ukuhambelana nezinye izithako, ukuqwalaselwa kokhuseleko, kunye neemfuno zokulawula nazo zichaphazela ukukhethwa kwe-solvents kunye neendlela zokuchithwa.Ukongeza, kubalulekile ukwenza izifundo zokuhambelana kunye novavanyo lozinzo ukuqinisekisa ukuba inkqubo yokupheliswa ayichaphazeli kakubi umgangatho okanye ukusebenza kwemveliso yokugqibela.
Ixesha lokuposa: Mar-22-2024