I-Hydroxypropyl methyl cellulose HPMC yi-cellulose engeyiyo-ionic exutywe ne-ether kwiindidi kunye ne-ionic methyl carboxymethyl cellulose exutywe i-ether, ayisebenzi ngesinyithi esinzima.Enye i-oxygen radicals ngenxa yomxholo we-hydroxypropyl methyl cellulose kunye nenxalenye eyahlukileyo yomxholo we-hydroxypropyl kunye ne-viscosity, yaba ziintlobo ezahlukeneyo ekusebenzeni, umzekelo, umxholo ophezulu we-methoxyl kunye nomxholo ophantsi weentlobo ze-hydroxypropyl, ukusebenza kwayo kusondele kwi-methyl cellulose kunye ne-methoxyl ephantsi. Umxholo kunye nomxholo ophezulu weentlobo ze-hydroxypropyl, kwaye ukusebenza kwayo kukufutshane ne-hydroxypropyl methyl cellulose eveliswayo.Kodwa kwindidi nganye, nangona iqulethe kuphela inani elincinci le-hydroxypropyl okanye inani elincinci le-methoxy, ukunyibilika kwi-solvents eziphilayo okanye ubushushu be-flocculation kwisisombululo se-aqueous, kukho umahluko omkhulu.
1, i-hydroxypropyl methyl cellulose ukunyibilika
IHydroxypropyl methyl cellulose kunyibiliko lwamanzi lwe-hydroxypropyl methyl cellulose eneneni luhlobo lwepropylene oxide (i-methyl oxypropyl ring) ehlaziyiweyo ye-methyl cellulose, ngoko ke isefana ne-methyl cellulose yamanzi abandayo anyibilikayo kunye neempawu zamanzi ashushu ezinganyibilikiyo.Nangona kunjalo, ubushushu be-gelation ye-hydroxy propyl elungisiweyo iphezulu kakhulu kune-methyl cellulose emanzini ashushu.Ngokomzekelo, i-viscosity ye-hydroxypropyl methylcellulose isisombululo se-aqueous kunye ne-2% ye-methoxy content DS=0.73 kunye nomxholo we-hydroxypropyl MS=0.46 yi-500 mpa kwi-20℃.Ubushushu bejeli yemveliso ye-S busondele kwi-100℃, ngelixa i-methyl cellulose yobushushu obufanayo bumalunga ne-55℃ kuphela.Ngokubhekiselele kwi-solubility yayo emanzini, nayo iphuculwe kakhulu, umzekelo, emva kokutyunyuzwa kwe-hydroxypropyl methylcellulose (i-grain shape 0.2 ~ 0.5mm kwi-20 ℃ 4% viscosity yamanzi ye-2pA? Iimveliso ze-S zinokunyibilika ngokulula emanzini ngaphandle kokupholisa kwiqondo lokushisa. .
(2) I-Hydroxypropyl methyl cellulose kwi-organic solvents solubility ye-hydroxypropyl methyl cellulose kwi-solubility ye-organic solvents, ikwangcono kune-methyl cellulose, i-methyl cellulose idinga kwi-methoxy substitution degree ye-2.1 okanye ngaphezulu kweemveliso, kwaye iqulethe i-hydroxypropyl MS = 1.5 ~ 1.8 kunye ne-methoxy I-DS=0.2 ~ 1.0, I-viscosity ephezulu ye-hydroxypropyl methyl cellulose ene-degree substitution degree ngaphezu kwe-1.8 iyanyibilika kwi-anhydrous methanol kunye ne-ethanol isisombululo, kwaye ine-thermoplastic kunye ne-solubility yamanzi.Ikwanyibilika kwiihydrocarbon eziklorini ezifana ne-dichloromethane kunye ne-trichloromethane, kunye nezinyibilikisi ze-organic ezifana ne-acetone, i-isopropyl alcohol, kunye ne-diacetone alcohol.Ukunyibilika kwayo kwizinyibilikisi zendalo kuphezulu kunonyibiliko lwamanzi.
2, i-hydroxypropyl methyl cellulose viscosity yezinto ezichaphazelayo
I-Hydroxypropyl methylcellulose viscosity factor hydroxypropyl methylcellulose standard viscosity determination, kunye nenye i-cellulose ether iyafana, zikwi-20℃ kunye ne-2% yesisombululo se-aqueous njengommiselo womgangatho.I-viscosity yemveliso efanayo, ngokunyuka koxinzelelo kunye nokunyuka, ukuxinwa okufanayo kweemveliso ezahlukeneyo ze-molecular weight, ubunzima be-molecular yemveliso yi-viscosity ephezulu.Ubudlelwane bayo kunye nobushushu bufana ne-methyl cellulose.Xa iqondo lokushisa liphakama, i-viscosity iqala ukuhla, kodwa xa ifikelela kwiqondo lokushisa elithile, i-viscosity iphakama ngokukhawuleza kwaye i-gelation iyenzeka.Ubushushu be-gelation yeemveliso ezine-viscosity ephantsi ziphezulu kuneemveliso ezine-viscosity ephezulu.Inqanaba le-gel point yayo, ngaphezu kwe-viscosity ephezulu kunye nephantsi ye-ether, kodwa kunye ne-ether methoxy kunye ne-hydroxypropyl iqela lokubunjwa kweqela kunye neqondo elipheleleyo lokutshintshwa lihambelana.Kufuneka kuqatshelwe ukuba i-hydroxypropyl methylcellulose nayo i-pseudoplastic;isisombululo sayo sizinzile xa sigcinwe kwindawo yokushisa kwaye ayibonisi nakuphi na ukuthotywa kwe-viscosity ngaphandle kokuba kunokwenzeka ukuchithwa kwe-enzymatic.
I-3, i-hydroxypropyl methyl cellulose acid kunye nokumelana ne-alkaline
I-Hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid kunye nealkali, ngokuqhelekileyo izinzile, kwi-ph PH2 ~ 12 uluhlu aluchaphazeleki, lunokumelana nomlinganiselo othile we-asidi ekhanyayo, njenge-formic acid, i-acetic acid, i-citric acid, i-succinic acid, i-phosphoric. i-asidi, i-boric acid, njl. Kodwa i-asidi egxininisiweyo inefuthe lokunciphisa i-viscosity.I-alkali efana ne-caustic soda, i-potassium ye-caustic kunye ne-lime yamanzi ayinayo impembelelo kuyo, kodwa umphumo wokunyusa kancinci i-viscosity yesisombululo uya kuncipha ngokukhawuleza kwixesha elizayo.
4, i-hydroxypropyl methyl cellulose inokuxutywa
Isisombululo se-Hydroxypropyl methyl cellulose sinokuxutywa kunye neekhompawundi zepolymer ezinyibilikayo emanzini, kwaye zibe sisisombululo esicacileyo esifanayo kunye ne-viscosity ephezulu.Ezi khompawundi high molecular polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane kunye hydroxyethyl cellulose kunye methyl cellulose, njl. Iikhompawundi zepolymer zendalo ezifana gum Arabic, iinkumbi bean, itshungama imithi enameva njalo njalo kwakhona umxube elungileyo kunye yayo. isisombululo.IHydroxypropyl methyl cellulose ingaxutywa ne-stearic acid okanye i-palmitic acid mannitol ester okanye i-sorbitol ester, kodwa kunye ne-glycerol, i-sorbitol kunye ne-mannitol, ezi zixhobo zingasetyenziswa njenge-hydroxypropyl methyl cellulose plasticizer.
5, i-hydroxypropyl methyl cellulose enganyibilikiyo emanzini
IHydroxypropyl methyl cellulose enganyibilikiyo selulose ether eselulosini, inokudityaniswa nomphezulu we-aldehydes, kwaye yenze le ether enyibilikayo emanzini igalelwe kwisisombululo, inganyibiliki emanzini.Kwaye wenze i-hydroxypropyl methylcellulose i-aldehyde enganyibilikiyo, i-formaldehyde, i-glyoxal, i-succinaldehyde, i-dialdehyde, njl., Ukusetyenziswa kwe-formaldehyde kufuneka kuhlawule ingqalelo ekhethekileyo kwixabiso le-PH yesisombululo, apho ukusabela kwe-glyoxal ngokukhawuleza, ngoko kwimveliso yemizi-mveliso ngokuqhelekileyo kusetyenziswa i-glyoxal njengomnqamlezo. -ejenti yokudibanisa.I-dosage yolu hlobo lwe-agent agent kwisisombululo ngu-0.2% ~ 10% ye-ether mass, eyona nto ingcono kakhulu yi-7% ~ 10%, njengokusetyenziswa kwe-glyoxal kunye ne-3.3% ~ 6% yeyona nto ifanelekileyo.Ubushushu bonyango jikelele ngu-0 ~ 30℃, ixesha ngu-1 ~ 120min.Ukusabela kwe-cross-linking kufuneka kuqhutywe phantsi kweemeko ze-acidic.Ngokubanzi, i-asidi elomeleleyo ye-inorganic okanye i-organic carboxylic acid yongezwa kwisisombululo ukulungisa i-PH yesisombululo malunga ne-2 ~ 6, ngokukodwa phakathi kwe-4 ~ 6, kwaye i-aldehydes yongezwa kwi-cross-linking reaction.I-acids esetyenzisiweyo yi-hydrochloric acid, i-sulfuric acid, i-phosphoric acid, i-fomic acid, i-acetic acid, i-hydroxy acetic acid, i-succinic acid okanye i-citric acid, phakathi kwayo i-formic acid okanye i-acetic acid iyona nto ibhetele, ngelixa i-formic acid ingcono kakhulu.I-Acids kunye ne-aldehydes nazo zinokongezwa ngexesha elifanayo ukuvumela isisombululo ukuba sidibaniswe kuluhlu olufunwayo lwe-PH.Le mpendulo idla ngokusetyenziswa kwinkqubo yokugqibela yenkqubo yokulungiselela i-cellulose ether, ukuze i-cellulose ether inganyibiliki, kulula ukuyisebenzisa 20 ~ 25℃ amanzi ukuhlamba nokucoca.Xa imveliso isetyenzisiweyo, izinto ze-alkali zingongezwa kwisisombululo semveliso ukulungisa i-PH yesisombululo ukuba ibe yi-alkaline, kwaye imveliso ichithwa ngokukhawuleza kwisisombululo.Le ndlela ingasetyenziswa kwakhona xa isisombululo se-ether cellulose sisetyenziselwa ukwenza ifilimu kwaye emva koko ifilimu iphathwa ukwenza ifilimu enganyibilikiyo.
6, i-hydroxypropyl methyl cellulose anti-enzyme
I-Hydroxypropyl methyl cellulose ukumelana ne-enzyme ye-cellulose derivatives kwithiyori, efana neqela ngalinye le-anhydroglucose njengoko kukho indibaniselwano eqinileyo yokutshintsha amaqela, ukhukuliseko lwe-microorganisms aluchaphazeleki kancinci kusulelo, kodwa eneneni imveliso egqityiweyo yokutshintsha ixabiso elingaphezulu kwe-1, kwakhona ngokuwohloka enzyme, le inkcazo yeqela ngalinye kwisidanga cellulose chain substitution ayifani, Microorganisms inokukhukulisa kufuphi unsubstituted dehydrated amaqela glucose ukwenza iswekile, leyo inokufunxwa microorganisms njengokutya.Ngoko ke, ukuba iqondo lokuthatha indawo ye-etherification yeselulosi liyenyuka, ukuxhathisa kwe-cellulose ether kukhukuliseko lwe-enzymatic kuya kwandiswa.Kuxelwa ukuba phantsi kweemeko ezilawulwayo, i-viscosity eseleyo ye-hydroxypropyl methyl cellulose (DS = 1.9), i-methyl cellulose (DS = 1.83), i-methyl cellulose (DS = 1.66), kunye ne-hydroxyethyl cellulose (1.7%) yayingu-13.2%, 7.3%. , 3.8%, kunye ne-1.7%, ngokulandelanayo.IHydroxypropyl methyl cellulose inamandla okuchasa i-enzyme.Ngaloo ndlela i-hydroxypropyl methylcellulose i-anti-enzyme egqwesileyo, idibene ne-dispersion yayo efanelekileyo, ukuqina kunye nokwakheka kwefilimu, isetyenziswe kwiingubo ze-emulsion, njl.Nangona kunjalo, ukwenzela ukuthintela ukugcinwa kwexesha elide lesisombululo okanye ukungcoliseka okunokwenzeka kwihlabathi langaphandle, izilondolozo zinokongezwa, okukhethwa kuzo kunokumiselwa ngokweemfuno zokugqibela zesisombululo.I-Phenylmercuric acetate kunye ne-manganese fluosilicate zizigcini ezisebenzayo, kodwa ziyityhefu kwaye kufuneka ziqhutywe ngononophelo.Ngokuqhelekileyo, i-1 ~ 5mg phenylmercuric acetate inokongezwa kwilitha nganye yesisombululo.
I-7, ukusebenza kwe-hydroxypropyl methyl cellulose membrane
Ukusebenza kwefilimu ye-Hydroxypropyl methyl cellulose ye-hydroxypropyl methyl cellulose inefilimu egqwesileyo, isisombululo sayo samanzi okanye isisombululo se-solvent ye-organic, ifakwe kwi-plate yeglasi, emva kokumisa ingabi mbala, ibonakale kwaye ifilimu inzima.Inokumelana nokufuma okuhle kwaye ihlala yomelele kumaqondo obushushu aphezulu.Njengokongezwa kwe-plasticizer ye-hygroscopic, kunokunyusa ukuphakama kwayo kunye nokuguquguquka, ukuphucula i-flexure, i-glycerol kunye ne-sorbitol kunye nezinye i-plasticizer yeyona ifanelekileyo.Ukugxininiswa kwesisombululo ngokubanzi yi-2% ~ 3%, i-plasticizer dosage yi-10% ~ 20% ye-cellulose ether.Ukuba umxholo we-plasticizer unamandla, i-shrinkage phenomenon ye-colloid dehydration ingenzeka kumswakama ophezulu.Amandla e-tensile yefilimu eyongeziweyo i-plasticizer inkulu kakhulu kunokuba ingafakwanga, kwaye iyanda ngokunyuka kwenani elongezelelweyo, njengoko i-hygroscopicity yefilimu iphinda inyuke ngokunyuka kwenani le-plasticizer.
Ixesha lokuposa: Sep-08-2022