Ukuvelisa i-Hydroxypropyl Methylcellulose (HPMC) ibandakanya amanyathelo amaninzi antsonkothileyo aguqula i-cellulose ibe yipolymer eguquguqukayo enoluhlu olubanzi lwezicelo kumashishini ahlukeneyo.Le nkqubo iqala ngokutsalwa kweselulosi kwimithombo esekwe kwizityalo, ilandelwa lutshintsho lweekhemikhali ukwazisa amaqela e-hydroxypropyl kunye ne-methyl kwi-cellulose backbone.Iziphumo zepolymer zeHPMC zibonelela ngeempawu ezizodwa ezinjengokuqina, ukubopha, ukwenza ifilimu, kunye nokugcinwa kwamanzi.Makhe sihlolisise inkqubo eneenkcukacha yemveliso ye-HPMC.
1. Ukufumana iMathiriyeli ekrwada:
Eyona mathiriyeli ekrwada yokuqala yemveliso ye-HPMC yiselulosi, ephuma kwimithombo esekwe kwizityalo efana nentlaka yeenkuni, iilitha zomqhaphu, okanye ezinye izityalo ezineefayibha.Le mithombo ikhethwa ngokusekelwe kwizinto ezinjengobunyulu, umxholo we-cellulose, kunye nokuzinza.
2. Ukutsalwa kweSelulosi:
I-cellulose ikhutshwe kwimithombo ekhethiweyo yezityalo ngokusebenzisa uchungechunge lweenkqubo zoomatshini kunye neekhemikhali.Ekuqaleni, loo nto ikrwada ilungiswa kwangaphambili, nto leyo esenokuquka ukuhlanjwa, ukucolwa, nokuwomisa ukuze kususwe ukungcola nokufuma.Emva koko, i-cellulose iphathwa ngeekhemikhali ezifana ne-alkalis okanye i-acids ukudiliza i-lignin kunye ne-hemicellulose, ishiya ngasemva imicu ye-cellulose ecocekileyo.
3. Etherification:
I-Etherification yinkqubo ephambili yeekhemikhali kwimveliso ye-HPMC, apho i-hydroxypropyl kunye namaqela e-methyl aziswa kwi-cellulose backbone.Eli nyathelo libalulekile ekuguquleni iimpawu zeselulosi ukufezekisa imisebenzi efunekayo ye-HPMC.I-Etherification ngokuqhelekileyo iqhutyelwa ngokusabela kweselulosi ngepropylene oxide (yamaqela e-hydroxypropyl) kunye ne-methyl chloride (yamaqela e-methyl) phambi kwee-catalysts ze-alkali phantsi kweemeko ezilawulwayo zobushushu kunye noxinzelelo.
4. Ukungathathi hlangothi kunye neWashing:
Emva kwe-etherification, umxube wokuphendula awuthathi hlangothi ukuze ususe naziphi na ii-alkali catalysts eziseleyo kunye nokulungelelanisa izinga le-pH.Oku kuqhele ukwenziwa ngokudibanisa iasidi okanye isiseko ngokuxhomekeke kwiimeko ezithile zokusabela.I-Neutralization ilandelwa kukuhlanjwa ngokucokisekileyo ukususa iimveliso, iikhemikhali ezingaphendulwanga, kunye nokungcola kwimveliso ye-HPMC.
5. Ukuhluza kunye nokomisa:
Isisombululo se-HPMC esingathathi hlangothi kwaye sihlanjwe sihlanjululwa ukuze sihlukanise amaqhekeza aqinileyo kwaye sifezekise isisombululo esicacileyo.Ukuhluza kunokubandakanya iindlela ezahlukeneyo ezinje ngokucoca ivacuum okanye i-centrifugation.Emva kokuba isisombululo sicacisiwe, somiswa ukususa amanzi kwaye sifumane i-HPMC kwifom yomgubo.Iindlela zokomisa zingabandakanya ukomisa isitshizi, ukomisa umandlalo omanzi, okanye ukomisa igubu, kuxhomekeke kubungakanani besuntswana elifunekayo kunye neempawu zemveliso yokugqibela.
6. Ukusila kunye nokuhluzwa (Ngokuzithandela):
Kwezinye iimeko, i-powder ye-HPMC eyomileyo inokuqhubela phambili ukuqhutyelwa phambili njengokugaya kunye ne-sieving ukufezekisa ubungakanani obuthile kunye nokuphucula ukuhamba.Eli nyathelo linceda ukufumana i-HPMC eneempawu zomzimba ezihambelanayo ezifanelekileyo kwizicelo ezahlukeneyo.
7. Ulawulo loMgangatho:
Kuyo yonke inkqubo yemveliso, amanyathelo angqongqo olawulo lomgangatho aphunyezwa ukuqinisekisa ubunyulu, ukungaguquguquki, kunye nokusebenza kwemveliso ye-HPMC.Iiparamitha zokulawula umgangatho zingabandakanya i-viscosity, ukusabalalisa ubungakanani be-particle, umxholo womswakama, i-degree of substitution (DS), kunye nezinye iimpawu ezifanelekileyo.Iindlela zokuhlalutya ezifana nemilinganiselo ye-viscosity, i-spectroscopy, i-chromatography, kunye ne-microscopy ziqhelekileyo zisetyenziselwa ukuhlolwa komgangatho.
8. Ukupakishwa kunye noGcino:
Nje ukuba imveliso ye-HPMC iphumelele iimvavanyo zolawulo lomgangatho, ipakishwe kwizikhongozeli ezifanelekileyo ezinjengeengxowa okanye imigqomo kwaye ibhalwe ngokweenkcukacha.Ukupakishwa okufanelekileyo kunceda ukukhusela i-HPMC kumswakama, ungcoliseko, kunye nomonakalo womzimba ngexesha lokugcinwa kunye nokuthutha.I-HPMC epakishweyo igcinwe kwiimeko ezilawulwayo ukugcina uzinzo kunye neshelufu-ubomi de ilungele ukuhanjiswa kunye nokusetyenziswa.
Usetyenziso lwe-HPMC:
IHydroxypropyl Methylcellulose ifumana ukusetyenziswa okubanzi kumashishini ahlukeneyo kubandakanya amayeza, ulwakhiwo, ukutya, izinto zokuthambisa, kunye neemveliso zokhathalelo lomntu.Kumachiza, isetyenziswe njenge-binder, i-disintegrant, ifilimu yangaphambili, kunye ne-ejenti yokukhululwa okuqhubekayo kwi-tablet formulations.Ekwakhiweni, i-HPMC iqeshwe njenge-thickener, i-arhente yokugcina amanzi, kunye ne-rheology modifier kwi-samente-based mortars, i-plasters, kunye ne-adhesives tile.Ekutyeni, isebenza njenge-thickener, stabilizer, kunye ne-emulsifier kwiimveliso ezifana neesosi, isuphu, kunye nezimuncumuncu.Ukongeza, i-HPMC isetyenziswa kwizinto zokuthambisa kunye neemveliso zokhathalelo lomntu ukwenza ifilimu, ukunyakamisa, kunye neempawu zokuguqula ukuthungwa.
Iingqwalasela zokusiNgqongileyo:
Ukuveliswa kweHPMC, njengeenkqubo ezininzi zamashishini, kuneempembelelo zokusingqongileyo.Iinzame ziyenziwa ukuphucula uzinzo lwemveliso ye-HPMC ngamaphulo afana nokusebenzisa imithombo yamandla ahlaziyekayo, ukwandisa ukusetyenziswa kwemathiriyeli ekrwada, ukunciphisa ukuveliswa kwenkunkuma, kunye nokuphumeza ubugcisa bemveliso obulungele indalo.Ukongeza, ukuphuhliswa kwe-bio-based HPMC evela kwimithombo ezinzileyo efana ne-algae okanye i-microbial fermentation ibonisa isithembiso ekunciphiseni indawo yendalo yemveliso ye-HPMC.
ukuveliswa kwe-Hydroxypropyl Methylcellulose kubandakanya uchungechunge lwamanyathelo aqala kwi-cellulose extraction ukuya kukuguqulwa kweekhemikhali, ukuhlanjululwa, kunye nokulawula umgangatho.Isiphumo sepolymer yeHPMC ibonelela ngoluhlu olubanzi lwemisebenzi kwaye ifumana usetyenziso kumashishini ahlukeneyo.Iinzame ezibhekiselele kuzinzo kunye noxanduva lokusingqongileyo ziqhuba izinto ezintsha kwimveliso ye-HPMC, ejolise ekunciphiseni ifuthe layo lokusingqongileyo ngelixa ihlangabezana nemfuno ekhulayo yale polima esebenza ngeendlela ezininzi.
Ixesha lokuposa: Mar-05-2024