Ukugquma ifilimu yinkqubo ebalulekileyo ekwenzeni amayeza, apho umaleko obhityileyo wepolymer ugalelwa kumphezulu weetafile okanye iicapsules.Le ngubo isebenza ngeenjongo ezahlukeneyo, kubandakanywa nokuphucula ukubonakala, ukunambitha, ukukhusela isithako esisebenzayo seyeza (API), ukulawula ukukhululwa, kunye nokuququzelela ukugwinya.IHydroxypropyl Methylcellulose (HPMC) yenye yeepolima ezisetyenziswa kakhulu ekugqumeni ifilimu ngenxa yeempawu zayo eziguquguqukayo.
1. Iipropati ze-HPMC:
IHydroxypropyl Methylcellulose (HPMC) yi-semi-synthetic polymer ephuma kwi-cellulose.Ibonakaliswa ngokunyibilika kwayo kwamanzi, amandla okwenza ifilimu, kunye nokuhambelana okugqwesileyo kunye nezithako ezahlukeneyo zamayeza.Iipropati ze-HPMC zinokulungelelaniswa ngokuguqula iiparamitha ezinjengobunzima bemolekyuli, iqondo lokuthatha indawo, kunye ne-viscosity.
Isakhono sokwenza ifilim: I-HPMC ineempawu ezibalaseleyo zokwenza ifilim, ezivumela ukwakheka kweyunifomu kunye nokugquma okugudileyo kumphezulu weefom zedosi yamayeza.
Ukunyibilika kwamanzi: I-HPMC ibonisa ukunyibilika kwamanzi, ivumela ukuchithwa kwepolymer kwizisombululo zamanzi ngexesha lenkqubo yokugubungela.Le propati iqinisekisa ukuhanjiswa okufanayo kwepolymer kwaye iququzelele ukubunjwa kwe-homogeneous coating layer.
Ukubambelela: I-HPMC ibonisa ukubambelela kakuhle kumphezulu weepilisi okanye ii-capsules, okubangelwa iingubo ezihlala zihlala zihambelana kakuhle ne-substrate.
IiPropati zoMthintelo: I-HPMC ibonelela ngomqobo ngokuchasene nezinto zokusingqongileyo ezifana nokufuma, ioksijini, kunye nokukhanya, ngaloo ndlela ikhusela ingqibelelo yefomu yedosi kunye nokuphucula uzinzo.
2.Iingqwalasela zokuqulunqa:
Ekuqulunqeni isisombululo sokugquma ifilimu usebenzisa i-HPMC, izinto ezininzi kufuneka ziqwalaselwe ukufikelela kwiimpawu ezinqwenelekayo zokugquma kunye nokusebenza.
I-Polymer Concentration: Ukuxininiswa kwe-HPMC kwisisombululo sokugquma kuchaphazela ubukhulu kunye neempawu zomatshini zefilimu.Ukugxila okuphezulu kwepolymer kukhokelela kwiingubo ezityebileyo ezineempawu zokuthintelwa eziphuculweyo.
Iiplastiki zeplastiki: Ukongezwa kweeplastiki ezifana ne-polyethylene glycol (PEG) okanye i-propylene glycol (PG) inokuphucula ukuguquguquka kunye nokuqina kwengubo, okwenza kube yinto encinci kwaye ixhathise ukuqhekeka.
Izinyibilikisi: Ukukhethwa kwezinyibilikisi ezifanelekileyo kubalulekile ukuqinisekisa ukunyibilika kwe-HPMC kunye nokwenziwa kwefilimu ngokufanelekileyo.Izinyibilikisi eziqhelekileyo ziquka amanzi, i-ethanol, i-isopropanol, kunye nemixube yayo.
I-Pigments kunye ne-Opacifiers: Ukudityaniswa kwe-pigments kunye ne-opacifiers kwi-formation ye-coating inokunika umbala, iphucule inkangeleko, kwaye inikeze ukhuseleko olulula kumachiza abuthathaka.
3.Izicelo ze-HPMC kwiNgqungquthela yeFilimu:
Iingubo ezisekelwe kwi-HPMC zifumana izicelo ezibanzi kumashishini amayeza kunye ne-nutraceutical ngenxa yokuguquguquka kwazo kunye nokufaneleka kweefom ezahlukeneyo zedosi.
Iingubo zokukhupha ngokukhawuleza: Iingubo ze-HPMC zingasetyenziselwa ukubonelela ngokukhawuleza kwamachiza ngokulawula ukuchithwa kunye nokuchithwa kweepilisi okanye iipilisi.
IiNgqungquthela eziLungisiweyo zokuKhululwa: Iifomyula ezisekelwe kwi-HPMC zidla ngokusetyenziswa kwiifom zedosi yokukhululwa ezilungisiweyo, kubandakanywa ukukhutshwa okwandisiweyo kunye ne-enteric-coated formulations.Ngokuguqula i-viscosity kunye nobukhulu bengubo, iprofayili yokukhupha iyeza inokulungelelaniswa ukufezekisa ukukhululwa okuzinzileyo okanye okujoliswe kuyo.
I-Taste Masking: Iingubo ze-HPMC zinokufihla incasa engathandekiyo yamachiza, ukuphucula ukuthotyelwa kwesigulane kunye nokwamkelwa kweefom zedosi yomlomo.
Ukhuseleko lokufuma: Iingubo ze-HPMC zibonelela ngokhuseleko olusebenzayo lokufuma, ngakumbi kumachiza e-hygroscopic athanda ukonakaliswa xa ebesesichengeni sokufuma.
Ukuphuculwa kozinzo: Iingubo ze-HPMC zibonelela ngomqobo wokukhusela kwizinto ezisingqongileyo, ngaloo ndlela ziphucula ukuzinza kunye neshelufu-ubomi beemveliso zamachiza.
IHydroxypropyl Methylcellulose (HPMC) idlala indima ebalulekileyo kwizicelo zokugquma ifilimu kwishishini lamayeza.Iimpawu zayo ezikhethekileyo, kubandakanywa amandla okwenza ifilimu, ukunyibilika kwamanzi, ukunamathela, kunye neempawu zokuthintela, zenza kube lukhetho olufanelekileyo lokuqulunqa iingubo kunye nemisebenzi eyahlukeneyo.Ngokuqonda ukuqwalaselwa kokuqulunqwa kunye nokusetyenziswa kwe-HPMC kwi-coating yefilimu, abavelisi bamachiza banokuphuhlisa iifom zedosi kunye nokusebenza okuphuculweyo, ukuzinza, kunye nokwamkeleka kwesigulane.
Ixesha lokuposa: Mar-07-2024