IHydroxypropyl Methylcellulose (HPMC) yipolymer eguquguqukayo efumana ukusetyenziswa okubanzi kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, ukwakhiwa, kunye nezithambiso.
1. Intshayelelo kwi-HPMC:
IHydroxypropyl Methylcellulose (HPMC) yi-semi-synthetic, inert, i-viscoelastic polymer ephuma kwi-cellulose.Yenziwa ngokuguqulwa kweekhemikhali zeselulosi, ezibandakanya i-etherification ye-alkali cellulose kunye nepropylene oxide kunye ne-methyl chloride.Imveliso ephumayo ngumgubo omhlophe ukuya komhlophe, ongenavumba, nongenancasa onyibilika emanzini kodwa onganyibilikiyo kwizinyibilikisi zendalo.
2. Ulwakhiwo kunye neePropati:
Ubume be-HPMC bunomqolo we-cellulose, ipholima yendalo eyenziwe ngeeyunithi zeglucose ezidityaniswe nge-β(1→4) glycosidic bond.Kwi-HPMC, amanye amaqela e-hydroxyl kwiiyunithi ze-glucose zitshintshwa nge-2-hydroxypropyl kunye namaqela e-methyl.Olu tshintsho luguqula iipropathi zepolymer xa kuthelekiswa neselulosi yemveli, inika ukunyibilika okuphuculweyo, i-viscosity, kunye nokukwazi ukwenza ifilimu.
Iipropati ze-HPMC ziyahluka ngokuxhomekeke kwizinto ezifana neqondo lokutshintshela (DS), ubunzima bemolekyuli, kunye nokusabalalisa ubungakanani bamasuntswana.Ngokubanzi, i-HPMC ibonisa:
Iipropati ezigqwesileyo zokwenza ifilimu
Ukuziphatha kwe-Thermal gelation
Umthamo ophezulu wokugcina amanzi
Uzinzo kuluhlu olubanzi lwe-pH
Ukuhambelana nezinye iipolymers kunye nezongezo
Ubume be-non-ionic, okwenza ukuba ihambelane nezithako ezahlukeneyo
3. Ukwenziwa kwe-HPMC:
Udibaniso lwe-HPMC lubandakanya amanyathelo aliqela:
Ukulungiswa kwe-alkali cellulose: I-Cellulose iphathwa ngesisombululo se-alkaline ukwenza i-alkali cellulose.
I-Etherification: I-alkali cellulose iphendula kunye ne-propylene oxide kunye ne-methyl chloride ukwazisa i-hydroxypropyl kunye namaqela e-methyl kumqolo we-cellulose.
Ukuhlamba kunye nokuhlanjululwa: Imveliso ephumayo ihlanjwe, ingathathi hlangothi, kwaye ihlanjululwe ukususa ukungcola.
Ukomisa: I-HPMC ecocekileyo yomisiwe ukuze ifumane imveliso yokugqibela kwifom yomgubo.
4. Usetyenziso lwe-HPMC:
I-HPMC ifumana izicelo ezixhaphakileyo kuwo wonke amashishini ahlukeneyo:
Amachiza: I-HPMC isetyenziswa kakhulu njenge-excipient yamachiza kwiipilisi zeepilisi, ukukhutshwa okulawulwayo, ukulungiswa kwamehlo, kunye nokumiswa.Isebenza njenge-binder, i-thickener, ifilimu yangaphambili, kunye ne-arhente yokukhululwa okuqhubekayo kwiifom ezahlukeneyo zedosi.
Ishishini lokutya: Kushishino lokutya, i-HPMC isetyenziswa njenge-thickener, stabilizer, emulsifier, kunye ne-ejenti yokugcina ukufuma kwiimveliso ezifana neempahla ezibhakiweyo, iimveliso zobisi, iisosi, kunye nezimuncumuncu.Iphucula ukuthungwa, ubomi beshelufu, kunye ne-mouthfeel kwiimveliso zokutya.
Ulwakhiwo: I-HPMC sisithako esiphambili kwizinto zokwakha ezifana nodaka olusekwe kwisamente, izinto zokuncamathelisa iithayile, kunye neemveliso ezisekwe kwigypsum.Isebenza njenge-ejenti yokugcina amanzi, iphucula ukusebenza, inciphisa ukugoba, kwaye ikhulise ukunamathela kwimiqulu yolwakhiwo.
Izinto zokuthambisa: I-HPMC isetyenziswa kwizinto zokuthambisa kunye neemveliso zokhathalelo lomntu njengento etyebisayo, isizinzisi, kunye nearhente yokwenza ifilim kwiimveliso ezifana neekhrimu, izinto zokuthambisa, iishampu, kunye neejeli.Inika i-viscosity, iphucula ukuthungwa, kwaye inika imvakalelo egudileyo, engenamafutha.
Ezinye ii-Aplikheshini: I-HPMC ikwaqeshwa kushicilelo olulukiweyo, iiseramikhi, iipeyinti, izicoci, kunye nanjengesithambiso kwiinkqubo ezahlukeneyo zemizi-mveliso.
5. Iimbono zexesha elizayo kunye nemingeni:
Imfuno ye-HPMC kulindeleke ukuba iqhubeke nokukhula ngenxa yeepropati zayo eziguquguqukayo kunye nezicelo ezahlukeneyo.Nangona kunjalo, imiceli mngeni efana nokuhla amaxabiso ezinto ezikrwada, izithintelo zolawulo, kunye nokhuphiswano oluvela kwezinye iipolima kunokuba nefuthe kuguquguquko lwentengiso.Iinzame zophando zijolise ekwandiseni ukusebenza kwe-HPMC, ukuhlola iindlela ezizinzileyo zokudibanisa, kunye nokwandisa usetyenziso lwayo kwiinkalo ezivelayo ezifana ne-biomedicine kunye ne-nanotechnology.
IHydroxypropyl Methylcellulose (HPMC) yipolymer exabisekileyo enoluhlu olubanzi lwezicelo kumashishini amaninzi.Ubume bayo obukhethekileyo, iipropathi, kunye nokudibanisa kuyenza ibe sisithako esibalulekileyo kumayeza, iimveliso zokutya, izinto zokwakha, izinto zokuthambisa, kunye nokusetyenziswa kwemizi-mveliso eyahlukeneyo.Njengoko iinzame zophando kunye nophuhliso ziqhubeka, i-HPMC ikulungele ukuhlala ingumdlali ophambili kushishino lwepolymer, ibonelela ngezisombululo ezintsha zokuhlangabezana neemfuno zentengiso eziguqukayo.
Ixesha lokuposa: Mar-05-2024