Ukuze uqhathanise i-CMC (i-carboxymethylcellulose) kunye ne-HPMC (i-hydroxypropylmethylcellulose), kufuneka siqonde iimpawu zabo, izicelo, iingenelo, ukungonakali, kunye neemeko ezinokuthi zisetyenziswe.Zombini i-cellulose derivatives zisetyenziswa ngokubanzi kumashishini ahlukeneyo, kubandakanywa amayeza, ukutya, izimonyo kunye nokwakhiwa.Ngamnye uneempawu ezizodwa ezenza ukuba zilungele iinjongo ezahlukeneyo.Masenze uthelekiso olunzulu olubanzi ukuze sibone ukuba yeyiphi ebhetele kwiimeko ezahlukeneyo.
1. Inkcazo kunye nesakhiwo:
I-CMC (i-carboxymethylcellulose): I-CMC yi-derivative cellulose e-soluble yamanzi eveliswa yi-reaction ye-cellulose kunye ne-chloroacetic acid.Iqulethe amaqela e-carboxymethyl (-CH2-COOH) edityaniswe kwamanye amaqela e-hydroxyl ye-glucopyranose monomers eyenza i-cellulose backbone.
I-HPMC (i-hydroxypropyl methylcellulose): I-HPMC iphinda ibe yi-derivative cellulose e-soluble yamanzi eveliswa ngokuphatha i-cellulose nge-propylene oxide kunye ne-methyl chloride.Iqulethe i-hydroxypropyl kunye namaqela e-methoxy aqhotyoshelwe kwi-cellulose backbone.
2. Ukunyibilika:
I-CMC: Inyibilika kakhulu emanzini, yenza isisombululo esicacileyo, esibonakalayo.Ibonisa ukuziphatha kokuhamba kwe-pseudoplastic, okuthetha ukuba i-viscosity yayo iyancipha phantsi koxinzelelo lwe-shear.
HPMC: Kwakhona ukunyibilika emanzini, ukwenza isisombululo viscous kancinane kune CMC.Ikwabonisa ukuziphatha kwepseudoplastic.
3.Iimpawu zeRheological:
I-CMC: Ibonisa indlela yokuziphatha yokucheba, nto leyo ethetha ukuba i-viscosity yayo iyancipha ngokunyuka kwesantya sokucheba.Le propati yenza ukuba ilungele izicelo apho ukuqina kuyadingeka kodwa isisombululo kufuneka sihambe ngokulula phantsi kwe-chear, njengepeyinti, i-detergents kunye namayeza.
I-HPMC: ibonisa ukuziphatha okufanayo kwe-rheological kwi-CMC, kodwa i-viscosity yayo iphezulu ngokubanzi kwiindawo eziphantsi.Ineempawu ezingcono zokwenza ifilimu, eyenza ukuba ifaneleke kwizicelo ezifana neengubo, i-adhesives kunye ne-controlled-release-release formulations yamayeza.
4. Uzinzo:
CMC: Izinzile ngokubanzi kuluhlu olubanzi lwe-pH kunye nobushushu.Inokunyamezela amanqanaba aphakathi e-electrolytes.
I-HPMC: Izinzile ngakumbi kune-CMC phantsi kweemeko ezine-asidi, kodwa ingenza i-hydrolysis phantsi kweemeko ze-alkaline.Ikwanovakalelo kwi-divalent cations, enokubangela i-gelation okanye imvula.
5. Isicelo:
I-CMC: isetyenziswa ngokubanzi njenge-thickener, i-stabilizer kunye ne-arhente yokugcina amanzi ekutyeni (okufana ne-ayisikrimu, isosi), amayeza (afana neepilisi, ukumiswa) kunye nezithambiso (ezifana nekhrimu, i-lotion) kumashishini.
I-HPMC: Isetyenziswa kakhulu kwizinto zokwakha (umzekelo, izinto zokuncamathelisa iithayile zesamente, udaka, udaka), amayeza (umzekelo, iipilisi ezikhutshwayo ezilawulwayo, amayeza okubona amehlo), kunye nezinto zokuthambisa (umz., amathontsi eliso, iimveliso zokukhathalela ulusu).
6. Ubutyhefu kunye nokhuseleko:
I-CMC: Ivunywa ngokubanzi njengekhuselekile (GRAS) zii-arhente ezilawulayo xa isetyenziswa ngaphakathi kwemida ebekiweyo ekutyeni nakwizicelo zoxubo-mayeza.Iyabola kwaye ayinayo ityhefu.
I-HPMC: Ikwabonwa njengekhuselekile ukuba ingasetyenziswa ngaphakathi kwemida ecetyiswayo.I-biocompatible kwaye isetyenziswa ngokubanzi kwintsimi yamachiza njenge-arhente yokukhululwa elawulwayo kunye ne-tablet binder.
7. Iindleko kunye nokufumaneka:
I-CMC: Ngokuqhelekileyo iindleko ezisebenzayo kune-HPMC.Ifumaneka lula kubaboneleli abahlukeneyo kwihlabathi jikelele.
I-HPMC: Iyabiza kakhulu ngenxa yenkqubo yayo yokuvelisa kwaye ngamanye amaxesha ibonelelo elinyiniweyo elivela kubaboneleli abathile.
8. Impembelelo yokusingqongileyo:
I-CMC: I-Biodegradable, ephuma kwimithombo ehlaziyekayo (iselulosi).Ithathwa njengenobuhlobo nokusingqongileyo.
HPMC: Kwakhona biodegradable kwaye ephuma kwiselulosi, ngoko ke kakhulu friendly kokusingqongileyo.
Zombini i-CMC kunye ne-HPMC zineempawu ezizodwa ezibenza zibe izongezo ezixabisekileyo kumashishini amaninzi.Ukhetho phakathi kwabo luxhomekeke kwiimfuno ezithile zesicelo ezifana ne-solubility, viscosity, ukuzinza kunye nokuqwalaselwa kweendleko.Ngokubanzi, i-CMC inokukhethwa ngenxa yexabiso eliphantsi, uzinzo lwe-pH ebanzi, kunye nokufaneleka kokutya kunye nezicelo zokuthambisa.I-HPMC, kwelinye icala, inokuthandwa ngenxa ye-viscosity yayo ephezulu, iipropathi ezingcono zokwenza ifilim, kunye nokusetyenziswa kumayeza kunye nemathiriyeli yokwakha.Ekugqibeleni, ukhetho kufuneka lusekelwe kuqwalaselo olupheleleyo lwezi zinto kunye nokuhambelana nokusetyenziswa okujoliswe kuko.
Ixesha lokuposa: Feb-21-2024